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THE ANTI NEISSERIA MENINGITIDES B VACCINE OVERCOME THE THYMUS INDEPENDENCE OF POLYSACCHARIDE C IN TODDLER.

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Title: THE ANTI NEISSERIA MENINGITIDES B VACCINE OVERCOME THE THYMUS INDEPENDENCE OF POLYSACCHARIDE C IN TODDLER.
Authors: Pérez, O.1 oliverp@finlay.edu.cu, Lastre, M.1, Bracho, G.1, Del Campo, J.1, Rodríguez, T.1, Zayas, C.1, Taboada, C.1, Sierra, G.1
Source: Revista VacciMonitor (Vacunología y Temas Afines). Oct2002, Vol. 11 Issue 4, p1. 1p.
Subjects: NEISSERIA meningitidis, VACCINES, MEMBRANE proteins, THYMUS, POLYSACCHARIDES, ANTIGENS, TODDLERS, PHYSIOLOGY
Abstract: VA-MENGOC-BC™ is an outer membrane protein based vaccine of serogroup B of Neisseria meningitidis. It also contains the serogroup C polysaccharide (PsC) which is non-covalently incorporated. We recently demonstrated the participation of other mechanisms possibly involved in it's protection which include, first a characteristic Th1 response induced by this vaccine in young adults and toddler demonstrated at different levels: functional (presence of delayed-type hypersensitivity, opsonophagocytic and bactericidal activities and not immediate anaphylaxis nor passive cutaneous anaphylaxis); class and subclasses (IgG and IgG1); molecular (induction of IL2 and γIFN mRNA and not IL4 nor IL5 mRNA); posttranscriptional (production of IL2 and γIFN and not IL4 nor IL5 in supernatant of restimulated peripheral cells); and the biological activity of γIFN produced. Second, a typical anti-PsC IgG secondary response was induced in toddler which demonstrated that this vaccine overcome the absence of response of the PsC, a thymus independent (TI) antigens. As was expected, the unconjugated polysaccharide vaccine stimulated IgG2 antibody subclass in agreement with previous reports. The subclass response is changed by VA-MENGOC-BC™ to IgG4 and IgG3. Third, the priming induced by PsC not induced hyporesponsiveness after a booster dose. In conclusion, we showed: the induction of Th1 pattern at different levels, the influence of this pattern over the response of a TI antigen in toddler and the not induction of hyporesponsiveness by PsC antigens after a booster dose. [ABSTRACT FROM AUTHOR]
Copyright of Revista VacciMonitor (Vacunología y Temas Afines) is the property of Vacunas Finlay S.A. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: MedicLatina
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  Data: THE ANTI NEISSERIA MENINGITIDES B VACCINE OVERCOME THE THYMUS INDEPENDENCE OF POLYSACCHARIDE C IN TODDLER.
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  Data: <searchLink fieldCode="AR" term="%22Pérez%2C+O%2E%22">Pérez, O.</searchLink><relatesTo>1</relatesTo><i> oliverp@finlay.edu.cu</i><br /><searchLink fieldCode="AR" term="%22Lastre%2C+M%2E%22">Lastre, M.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Bracho%2C+G%2E%22">Bracho, G.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Del+Campo%2C+J%2E%22">Del Campo, J.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Rodríguez%2C+T%2E%22">Rodríguez, T.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Zayas%2C+C%2E%22">Zayas, C.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Taboada%2C+C%2E%22">Taboada, C.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Sierra%2C+G%2E%22">Sierra, G.</searchLink><relatesTo>1</relatesTo>
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  Data: VA-MENGOC-BC™ is an outer membrane protein based vaccine of serogroup B of Neisseria meningitidis. It also contains the serogroup C polysaccharide (PsC) which is non-covalently incorporated. We recently demonstrated the participation of other mechanisms possibly involved in it's protection which include, first a characteristic Th1 response induced by this vaccine in young adults and toddler demonstrated at different levels: functional (presence of delayed-type hypersensitivity, opsonophagocytic and bactericidal activities and not immediate anaphylaxis nor passive cutaneous anaphylaxis); class and subclasses (IgG and IgG1); molecular (induction of IL2 and γIFN mRNA and not IL4 nor IL5 mRNA); posttranscriptional (production of IL2 and γIFN and not IL4 nor IL5 in supernatant of restimulated peripheral cells); and the biological activity of γIFN produced. Second, a typical anti-PsC IgG secondary response was induced in toddler which demonstrated that this vaccine overcome the absence of response of the PsC, a thymus independent (TI) antigens. As was expected, the unconjugated polysaccharide vaccine stimulated IgG2 antibody subclass in agreement with previous reports. The subclass response is changed by VA-MENGOC-BC™ to IgG4 and IgG3. Third, the priming induced by PsC not induced hyporesponsiveness after a booster dose. In conclusion, we showed: the induction of Th1 pattern at different levels, the influence of this pattern over the response of a TI antigen in toddler and the not induction of hyporesponsiveness by PsC antigens after a booster dose. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Revista VacciMonitor (Vacunología y Temas Afines) is the property of Vacunas Finlay S.A. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Code: eng
        Text: English
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      Pagination:
        PageCount: 1
        StartPage: 1
    Subjects:
      – SubjectFull: NEISSERIA meningitidis
        Type: general
      – SubjectFull: VACCINES
        Type: general
      – SubjectFull: MEMBRANE proteins
        Type: general
      – SubjectFull: THYMUS
        Type: general
      – SubjectFull: POLYSACCHARIDES
        Type: general
      – SubjectFull: ANTIGENS
        Type: general
      – SubjectFull: TODDLERS
        Type: general
      – SubjectFull: PHYSIOLOGY
        Type: general
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      – TitleFull: THE ANTI NEISSERIA MENINGITIDES B VACCINE OVERCOME THE THYMUS INDEPENDENCE OF POLYSACCHARIDE C IN TODDLER.
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              Text: Oct2002
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              Y: 2002
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