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Diferencias de género en el perfil clínico, respuesta y remisión de pacientes depresivos tratados con venlafaxina retard.

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Title: Diferencias de género en el perfil clínico, respuesta y remisión de pacientes depresivos tratados con venlafaxina retard.
Alternate Title: Gender differences in the clinical profile, response and remission of depressed patients treated with venlafaxine extended release medicine.
Authors: Roca, M.1 mroca@uib.res, Baca Baldomero, E.2, Prieto, R.3, García-Calvo, C.3
Source: Actas Espanolas de Psiquiatria. mar2008, Vol. 36 Issue 2, p82-89. 8p. 3 Charts, 3 Graphs.
Subjects: THERAPEUTICS, MENTAL depression, VENLAFAXINE, ANTIDEPRESSANTS, PRIMARY care, SEX differences (Biology), ANXIETY
Abstract (English): Introduction. The primary objectives of this study are to evaluate gender-specific differences in the clinical profile of the primary care of depressed patients as well as in the clinical response and remission to venlafaxine extended release. Methods. We have analyzed a sample of 6,719 adult outpatients (1,713 men and 4,925 women) with a diagnosis of depression with associated anxiety symptoms included in an observational, prospective, multi center and open study. Venlafaxine extended release was administered for 24 weeks at a dosage of 75-225 mg/day. Results. In this study, we have not found overall differences regarding the baseline severity of the depressive episode, as assessed by means of the HAM-D17 and Clinical Global Impression Scale of Severity (CGI-S). However, women showed higher scores on items of the HAMD17 and HAM-A scales related with anxious and somatic complaints at baseline and endpoint. The percentage of remission on the HAM-D17 scale reached 75.4 % for men and 74.3 % for women (p = 0.4339) at week 24. In the case of HAM-A: 84.1 % vs. 80.6 % (men vs. women, p=0.004). Conclusions. We did not observe baseline differences in the mean score of the HAM-D17 nor the remission rates between women and men (HAM-D17) at the final visit. Women showed lower anxiety remission rates (HAM-A) and maintained more anxious and somatic complaints throughout the study. [ABSTRACT FROM AUTHOR]
Abstract (Spanish): Introducción. El objetivo principal de este estudio es evaluar las diferencias específicas de género en el perfil clínico de pacientes depresivos tratados en atención primaria, así como en la respuesta y remisión clínica a venlafaxina retard. Métodos. Se ha analizado una muestra de 6.719 pacientes ambulatorios adultos (1.713 hombres y 4.925 mujeres) con diagnóstico de síndrome depresivo con síntomas asociados de ansiedad incluidos en un estudio observacional, abierto, prospectivo y multicéntrico. Se administró venlafaxina de liberación retardada durante 24 semanas a dosis de 75-225 mg/día. Resultados. No se han encontrado en este estudio diferencias globales en cuanto a la gravedad basal del episodio depresivo, según las evaluaciones de la HAM-D17 y escala de Impresión Clínica Global de Severidad (ICG-S). No obstante, las mujeres presentaron puntuaciones más altas en ítems de las escalas HAM-D17 y HAM-A relacionados con quejas somáticas y de ansiedad en las visitas basal y final. El porcentaje de remisión en la escala HAM-D17 fue del 75,4 % en hombres y 74,3 % en mujeres (p= 0,4339) en la semana 24. En el caso de la HAM-A fue 84,1 frente a 80,6% (hombres frente a mujeres, p=0,004). Conclusiones. No se observaron diferencias basales en la puntuación media de la HAM-D17 ni en las tasas de remisión entre hombres y mujeres (HAM-D17) en la visita final. Las mujeres presentaron tasas de remisión de ansiedad más bajas (HAM-A) y conservaron más quejas somáticas y de ansiedad a lo largo del estudio. [ABSTRACT FROM AUTHOR]
Copyright of Actas Espanolas de Psiquiatria is the property of Maria Lopez-Ibor and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: MedicLatina
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  Data: Diferencias de género en el perfil clínico, respuesta y remisión de pacientes depresivos tratados con venlafaxina retard.
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  Data: Gender differences in the clinical profile, response and remission of depressed patients treated with venlafaxine extended release medicine.
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  Data: <searchLink fieldCode="AR" term="%22Roca%2C+M%2E%22">Roca, M.</searchLink><relatesTo>1</relatesTo><i> mroca@uib.res</i><br /><searchLink fieldCode="AR" term="%22Baca+Baldomero%2C+E%2E%22">Baca Baldomero, E.</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Prieto%2C+R%2E%22">Prieto, R.</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22García-Calvo%2C+C%2E%22">García-Calvo, C.</searchLink><relatesTo>3</relatesTo>
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  Data: <searchLink fieldCode="JN" term="%22Actas+Espanolas+de+Psiquiatria%22">Actas Espanolas de Psiquiatria</searchLink>. mar2008, Vol. 36 Issue 2, p82-89. 8p. 3 Charts, 3 Graphs.
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  Data: <searchLink fieldCode="DE" term="%22THERAPEUTICS%22">THERAPEUTICS</searchLink><br /><searchLink fieldCode="DE" term="%22MENTAL+depression%22">MENTAL depression</searchLink><br /><searchLink fieldCode="DE" term="%22VENLAFAXINE%22">VENLAFAXINE</searchLink><br /><searchLink fieldCode="DE" term="%22ANTIDEPRESSANTS%22">ANTIDEPRESSANTS</searchLink><br /><searchLink fieldCode="DE" term="%22PRIMARY+care%22">PRIMARY care</searchLink><br /><searchLink fieldCode="DE" term="%22SEX+differences+%28Biology%29%22">SEX differences (Biology)</searchLink><br /><searchLink fieldCode="DE" term="%22ANXIETY%22">ANXIETY</searchLink>
– Name: Abstract
  Label: Abstract (English)
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  Data: Introduction. The primary objectives of this study are to evaluate gender-specific differences in the clinical profile of the primary care of depressed patients as well as in the clinical response and remission to venlafaxine extended release. Methods. We have analyzed a sample of 6,719 adult outpatients (1,713 men and 4,925 women) with a diagnosis of depression with associated anxiety symptoms included in an observational, prospective, multi center and open study. Venlafaxine extended release was administered for 24 weeks at a dosage of 75-225 mg/day. Results. In this study, we have not found overall differences regarding the baseline severity of the depressive episode, as assessed by means of the HAM-D17 and Clinical Global Impression Scale of Severity (CGI-S). However, women showed higher scores on items of the HAMD17 and HAM-A scales related with anxious and somatic complaints at baseline and endpoint. The percentage of remission on the HAM-D17 scale reached 75.4 % for men and 74.3 % for women (p = 0.4339) at week 24. In the case of HAM-A: 84.1 % vs. 80.6 % (men vs. women, p=0.004). Conclusions. We did not observe baseline differences in the mean score of the HAM-D17 nor the remission rates between women and men (HAM-D17) at the final visit. Women showed lower anxiety remission rates (HAM-A) and maintained more anxious and somatic complaints throughout the study. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label: Abstract (Spanish)
  Group: Ab
  Data: Introducción. El objetivo principal de este estudio es evaluar las diferencias específicas de género en el perfil clínico de pacientes depresivos tratados en atención primaria, así como en la respuesta y remisión clínica a venlafaxina retard. Métodos. Se ha analizado una muestra de 6.719 pacientes ambulatorios adultos (1.713 hombres y 4.925 mujeres) con diagnóstico de síndrome depresivo con síntomas asociados de ansiedad incluidos en un estudio observacional, abierto, prospectivo y multicéntrico. Se administró venlafaxina de liberación retardada durante 24 semanas a dosis de 75-225 mg/día. Resultados. No se han encontrado en este estudio diferencias globales en cuanto a la gravedad basal del episodio depresivo, según las evaluaciones de la HAM-D17 y escala de Impresión Clínica Global de Severidad (ICG-S). No obstante, las mujeres presentaron puntuaciones más altas en ítems de las escalas HAM-D17 y HAM-A relacionados con quejas somáticas y de ansiedad en las visitas basal y final. El porcentaje de remisión en la escala HAM-D17 fue del 75,4 % en hombres y 74,3 % en mujeres (p= 0,4339) en la semana 24. En el caso de la HAM-A fue 84,1 frente a 80,6% (hombres frente a mujeres, p=0,004). Conclusiones. No se observaron diferencias basales en la puntuación media de la HAM-D17 ni en las tasas de remisión entre hombres y mujeres (HAM-D17) en la visita final. Las mujeres presentaron tasas de remisión de ansiedad más bajas (HAM-A) y conservaron más quejas somáticas y de ansiedad a lo largo del estudio. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Actas Espanolas de Psiquiatria is the property of Maria Lopez-Ibor and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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