DIFERENCIAS EN LA MORFOLOGIA DE LAS CELULAS PROSTATICAS EN LA CIRCULACION SANGUINEA (CPCS), CELULAS CANCEROSAS AISLADAS (CCAS) EN LA MEDULA OSEA Y CELULAS CANCEROSAS INFILTRANDO MICROGRUMOS EN LA MEDULA OSEA DE PACIENTES CON CANCER PROSTATICO, DETECTADAS UTILIZANDO METODOS DE INMUMOCITOQUIMICA.
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| Title: | DIFERENCIAS EN LA MORFOLOGIA DE LAS CELULAS PROSTATICAS EN LA CIRCULACION SANGUINEA (CPCS), CELULAS CANCEROSAS AISLADAS (CCAS) EN LA MEDULA OSEA Y CELULAS CANCEROSAS INFILTRANDO MICROGRUMOS EN LA MEDULA OSEA DE PACIENTES CON CANCER PROSTATICO, DETECTADAS UTILIZANDO METODOS DE INMUMOCITOQUIMICA. |
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| Alternate Title: | MORPHOLOGICAL DIFFERENCES BETWEEN CIRCULATING PROSTATE CELLS IN BLOOD AND BONE MARROW AND THOSE INFILTRATING BONE MARROW FRAGMENTS IN PATIENTS WITH PROSTATE CANCER, DETECTED USING IMMUNOCYTOCHEMICAL METHODS. |
| Authors: | Murray, Nigel R.1,2,3, Badínez V., Leonardo4, Cárdenas S., Mercedes5 |
| Source: | Revista Chilena de Tecnología Médica. 2009, Vol. 29 Issue 1, p1477-1483. 7p. |
| Subjects: | CELL morphology, BLOOD, BONE marrow, PROSTATE cancer, CENTRIFUGATION, IMMUNOCYTOCHEMISTRY, PROSTATE-specific antigen, BIOPSY |
| Abstract (English): | Describe and determine morphological differences between prostate cells found in blood and bone marrow in men with prostate cancer. Methods and Patients: After written informed consent, samples of blood and bone marrow were obtained from men with histological confirmed prostate cancer. Mononuclear cells were obtained by differential centrifugation and a touch-prep made from the biopsy sample. Prostate cells were identified using immunocytochemistry and defined as cells positive for anti-prostate specific antigen and negative for anti-CD45 (pan-leucocyte). Results: From the 71 patients studied, cells found in blood and bone marrow aspirates were round or oval, whereas the cells detected in microfragments of the biopsy showed the characters of a typical cancer cell, irregular in shape and size with long cytoplasmic processes. Conclusions: These morphological differences could be explained in that there are 2 populations of cells, those in blood or bone marrow aspirates with a round or oval appearance are in transit, circulating between the blood and other tissues such as bone marrow, and those found in microfragments which represent true micrometastasis. [ABSTRACT FROM AUTHOR] |
| Abstract (Spanish): | Objetivo: Describir y determinar diferencias en la morfología celular entre células prostáticas en la circulación sanguínea y muestras de la médula ósea en pacientes con cáncer prostático. Métodos y Pacientes: Después de un consentimiento informado por escrito, muestras de sangre venosa y médula ósea fueron extraídas de pacientes con cáncer prostático histológicamente confirmado. Células mononucleares fueron obtenidas por centrifugación diferencial y una impronta preparada de la biopsia de la médula ósea. Las células prostáticas fueron identificadas con inmunocitoquímica, definida como antígeno prostático específico positivo y CD45 (pan-leucocito) negativo. Resultados: De los 71 sujetos estudiados, las células obtenidas en sangre y aspiración de la médula ósea, fueron redondas u ovaladas, a diferencia de las células en los microgrumos o fragmentos que tuvieron las características típicas de las células malignas: irregulares, con diferencias en tamaño y con largos procesos citoplasmáticos. Conclusiones: Las diferencias en la morfología pueden ser explicadas debido a que habrían 2 tipos de células, unas circulando o en tránsito entre la sangre y otros tejidos -como médula ósea- con apariencia redonda u ovalada y las células en los microgrumos o fragmentos, que se han infiltrado la membrana endoostial y representan verdadera micrometástasis. [ABSTRACT FROM AUTHOR] |
| Copyright of Revista Chilena de Tecnología Médica is the property of Colegio de Tecnologos Medicos de Chile, A.G. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | MedicLatina |
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| Header | DbId: lth DbLabel: MedicLatina An: 44203958 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: DIFERENCIAS EN LA MORFOLOGIA DE LAS CELULAS PROSTATICAS EN LA CIRCULACION SANGUINEA (CPCS), CELULAS CANCEROSAS AISLADAS (CCAS) EN LA MEDULA OSEA Y CELULAS CANCEROSAS INFILTRANDO MICROGRUMOS EN LA MEDULA OSEA DE PACIENTES CON CANCER PROSTATICO, DETECTADAS UTILIZANDO METODOS DE INMUMOCITOQUIMICA. – Name: TitleAlt Label: Alternate Title Group: TiAlt Data: MORPHOLOGICAL DIFFERENCES BETWEEN CIRCULATING PROSTATE CELLS IN BLOOD AND BONE MARROW AND THOSE INFILTRATING BONE MARROW FRAGMENTS IN PATIENTS WITH PROSTATE CANCER, DETECTED USING IMMUNOCYTOCHEMICAL METHODS. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Murray%2C+Nigel+R%2E%22">Murray, Nigel R.</searchLink><relatesTo>1,2,3</relatesTo><br /><searchLink fieldCode="AR" term="%22Badínez+V%2E%2C+Leonardo%22">Badínez V., Leonardo</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Cárdenas+S%2E%2C+Mercedes%22">Cárdenas S., Mercedes</searchLink><relatesTo>5</relatesTo> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Revista+Chilena+de+Tecnología+Médica%22">Revista Chilena de Tecnología Médica</searchLink>. 2009, Vol. 29 Issue 1, p1477-1483. 7p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22CELL+morphology%22">CELL morphology</searchLink><br /><searchLink fieldCode="DE" term="%22BLOOD%22">BLOOD</searchLink><br /><searchLink fieldCode="DE" term="%22BONE+marrow%22">BONE marrow</searchLink><br /><searchLink fieldCode="DE" term="%22PROSTATE+cancer%22">PROSTATE cancer</searchLink><br /><searchLink fieldCode="DE" term="%22CENTRIFUGATION%22">CENTRIFUGATION</searchLink><br /><searchLink fieldCode="DE" term="%22IMMUNOCYTOCHEMISTRY%22">IMMUNOCYTOCHEMISTRY</searchLink><br /><searchLink fieldCode="DE" term="%22PROSTATE-specific+antigen%22">PROSTATE-specific antigen</searchLink><br /><searchLink fieldCode="DE" term="%22BIOPSY%22">BIOPSY</searchLink> – Name: Abstract Label: Abstract (English) Group: Ab Data: Describe and determine morphological differences between prostate cells found in blood and bone marrow in men with prostate cancer. Methods and Patients: After written informed consent, samples of blood and bone marrow were obtained from men with histological confirmed prostate cancer. Mononuclear cells were obtained by differential centrifugation and a touch-prep made from the biopsy sample. Prostate cells were identified using immunocytochemistry and defined as cells positive for anti-prostate specific antigen and negative for anti-CD45 (pan-leucocyte). Results: From the 71 patients studied, cells found in blood and bone marrow aspirates were round or oval, whereas the cells detected in microfragments of the biopsy showed the characters of a typical cancer cell, irregular in shape and size with long cytoplasmic processes. Conclusions: These morphological differences could be explained in that there are 2 populations of cells, those in blood or bone marrow aspirates with a round or oval appearance are in transit, circulating between the blood and other tissues such as bone marrow, and those found in microfragments which represent true micrometastasis. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Abstract (Spanish) Group: Ab Data: Objetivo: Describir y determinar diferencias en la morfología celular entre células prostáticas en la circulación sanguínea y muestras de la médula ósea en pacientes con cáncer prostático. Métodos y Pacientes: Después de un consentimiento informado por escrito, muestras de sangre venosa y médula ósea fueron extraídas de pacientes con cáncer prostático histológicamente confirmado. Células mononucleares fueron obtenidas por centrifugación diferencial y una impronta preparada de la biopsia de la médula ósea. Las células prostáticas fueron identificadas con inmunocitoquímica, definida como antígeno prostático específico positivo y CD45 (pan-leucocito) negativo. Resultados: De los 71 sujetos estudiados, las células obtenidas en sangre y aspiración de la médula ósea, fueron redondas u ovaladas, a diferencia de las células en los microgrumos o fragmentos que tuvieron las características típicas de las células malignas: irregulares, con diferencias en tamaño y con largos procesos citoplasmáticos. Conclusiones: Las diferencias en la morfología pueden ser explicadas debido a que habrían 2 tipos de células, unas circulando o en tránsito entre la sangre y otros tejidos -como médula ósea- con apariencia redonda u ovalada y las células en los microgrumos o fragmentos, que se han infiltrado la membrana endoostial y representan verdadera micrometástasis. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Revista Chilena de Tecnología Médica is the property of Colegio de Tecnologos Medicos de Chile, A.G. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Languages: – Code: spa Text: Spanish PhysicalDescription: Pagination: PageCount: 7 StartPage: 1477 Subjects: – SubjectFull: CELL morphology Type: general – SubjectFull: BLOOD Type: general – SubjectFull: BONE marrow Type: general – SubjectFull: PROSTATE cancer Type: general – SubjectFull: CENTRIFUGATION Type: general – SubjectFull: IMMUNOCYTOCHEMISTRY Type: general – SubjectFull: PROSTATE-specific antigen Type: general – SubjectFull: BIOPSY Type: general Titles: – TitleFull: DIFERENCIAS EN LA MORFOLOGIA DE LAS CELULAS PROSTATICAS EN LA CIRCULACION SANGUINEA (CPCS), CELULAS CANCEROSAS AISLADAS (CCAS) EN LA MEDULA OSEA Y CELULAS CANCEROSAS INFILTRANDO MICROGRUMOS EN LA MEDULA OSEA DE PACIENTES CON CANCER PROSTATICO, DETECTADAS UTILIZANDO METODOS DE INMUMOCITOQUIMICA. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Murray, Nigel R. – PersonEntity: Name: NameFull: Badínez V., Leonardo – PersonEntity: Name: NameFull: Cárdenas S., Mercedes IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 07 Text: 2009 Type: published Y: 2009 Identifiers: – Type: issn-print Value: 07160135 Numbering: – Type: volume Value: 29 – Type: issue Value: 1 Titles: – TitleFull: Revista Chilena de Tecnología Médica Type: main |
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