Effect of Mikania glomerata (Asteraceae) leaf extract combined with anti-venom serum on experimental Crotalus durissus (Squamata: Viperidae) envenomation in rats.
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| Title: | Effect of Mikania glomerata (Asteraceae) leaf extract combined with anti-venom serum on experimental Crotalus durissus (Squamata: Viperidae) envenomation in rats. |
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| Authors: | Floriano, Rafael Stuani, Nogueira, Rosa Maria Barilli1 rosa@unoeste.br, Sakate, Michiko, Laposy, Cecília Braga2, Pereira da Motta, Yudney, Sangiorgio, Fabíola, Costa David, Heloísa1, Nabas, João Marcelo3 |
| Source: | Revista de Biología Tropical. dec2009, Vol. 57 Issue 4, p929-937. 9p. 3 Charts. |
| Subjects: | ASTERACEAE, CROTALUS, VIPERIDAE, NEUROTOXICOLOGY, NEPHROTOXICOLOGY, LEUKOCYTES |
| Abstract (English): | Crotalic envenomation represents the highest number of deaths when compared to other snakebite envenomations of medical interest. Crotalic venom has important characteristics such as neurotoxicity, myotoxicity, nephrotoxicity, and clotting and hemolytic action. We evaluated the clinical and laboratory aspects of Crotalus durissus terrificus experimental envenomation in Wistar rats treated with antivenom and the aqueous extract of the plant Mikania glomerata. The animals were divided into three groups: Group C (control); Group VS-venom and antivenom; Group VSM-venom, antivenom and aqueous extract of M. glomerata. Crotalic poison caused clinical and laboratory alterations in Wistar mice. Significant clinical alterations were: temperature decrease, edema in the venom inoculated member, sedation and a locomotion decrease in groups VS and VSM when compared with group C. A faster recovery from sedation was observed only for animals of group VSM when compared to VS. There was an increase in the number of leukocytes, neutrophils and creatine kinase in the VS and VSM groups, compared to group C. Wistar rats showed a high resistance to crotalic venom. Additional studies with different doses, time of treatment, different administration methods and histopathological and immunological studies are necessary to understand the action of M. glomerata in crotalic accidents. Rev. Biol. Trop. 57 (4): 929-937. Epub 2009 December 01. [ABSTRACT FROM AUTHOR] |
| Abstract (Spanish): | El envenamiento crotálico representa el número más alto de muertes cuando es comparado con envenenamientos por mordeduras de otras serpientes de interés médico. El veneno crotálico tiene importantes características de acción neurotóxica, miotoxicidad, nefrotoxicidad, coagulación y acción hemolítica. Este trabajo evaluó los aspectos clínicos y de laboratorio del envenenamiento experimental con el veneno de la serpiente Crotalus durissus terrificus en las ratas Wistar tratadas con suero antiofídico y extracto acuoso de M. glomerata. Los animales fueron separados en tres diferentes grupos: grupo control (C); grupo veneno+suero (VS), grupo veneno+suero+extracto acuoso de M. glomerata (VSM). El veneno crotálico causó alteraciones clínicas y diferencias en los análisis sanguíneos practicados a los ratones Wistar evaluados. Las alteraciones clínicas más importantes fueron una disminución de la temperatura, edema en el miembro inoculado de veneno, la sedación y una disminución de la locomoción en los grupos VS y VSM comparado con el grupo C. Una rápida recuperación de la sedación estadísticamente significativa fue observada en los animales del grupo VSM al compararse con los del grupo VS. Los análisis sanguíneos mostraron un aumento en el número de leucocitos, neutrofilos y creatina quinasa en los grupos VS y VSM comparados con el grupo C. Los ratones Wistar mostraron una alta resistencia al veneno del crótalo. Estudios adicionales con variación en las dosis, tiempo de tratamiento, y métodos de administración, así como la realización de estudios histopatológicos e inmunológicos son importantes para comprender la acción de M. glomerata en accidentes crotálicos. [ABSTRACT FROM AUTHOR] |
| Copyright of Revista de Biología Tropical is the property of Universidad de Costa Rica and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | MedicLatina |
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| Header | DbId: lth DbLabel: MedicLatina An: 44622460 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Effect of Mikania glomerata (Asteraceae) leaf extract combined with anti-venom serum on experimental Crotalus durissus (Squamata: Viperidae) envenomation in rats. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Floriano%2C+Rafael+Stuani%22">Floriano, Rafael Stuani</searchLink><br /><searchLink fieldCode="AR" term="%22Nogueira%2C+Rosa+Maria+Barilli%22">Nogueira, Rosa Maria Barilli</searchLink><relatesTo>1</relatesTo><i> rosa@unoeste.br</i><br /><searchLink fieldCode="AR" term="%22Sakate%2C+Michiko%22">Sakate, Michiko</searchLink><br /><searchLink fieldCode="AR" term="%22Laposy%2C+Cecília+Braga%22">Laposy, Cecília Braga</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Pereira+da+Motta%2C+Yudney%22">Pereira da Motta, Yudney</searchLink><br /><searchLink fieldCode="AR" term="%22Sangiorgio%2C+Fabíola%22">Sangiorgio, Fabíola</searchLink><br /><searchLink fieldCode="AR" term="%22Costa+David%2C+Heloísa%22">Costa David, Heloísa</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Nabas%2C+João+Marcelo%22">Nabas, João Marcelo</searchLink><relatesTo>3</relatesTo> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Revista+de+Biología+Tropical%22">Revista de Biología Tropical</searchLink>. dec2009, Vol. 57 Issue 4, p929-937. 9p. 3 Charts. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22ASTERACEAE%22">ASTERACEAE</searchLink><br /><searchLink fieldCode="DE" term="%22CROTALUS%22">CROTALUS</searchLink><br /><searchLink fieldCode="DE" term="%22VIPERIDAE%22">VIPERIDAE</searchLink><br /><searchLink fieldCode="DE" term="%22NEUROTOXICOLOGY%22">NEUROTOXICOLOGY</searchLink><br /><searchLink fieldCode="DE" term="%22NEPHROTOXICOLOGY%22">NEPHROTOXICOLOGY</searchLink><br /><searchLink fieldCode="DE" term="%22LEUKOCYTES%22">LEUKOCYTES</searchLink> – Name: Abstract Label: Abstract (English) Group: Ab Data: Crotalic envenomation represents the highest number of deaths when compared to other snakebite envenomations of medical interest. Crotalic venom has important characteristics such as neurotoxicity, myotoxicity, nephrotoxicity, and clotting and hemolytic action. We evaluated the clinical and laboratory aspects of Crotalus durissus terrificus experimental envenomation in Wistar rats treated with antivenom and the aqueous extract of the plant Mikania glomerata. The animals were divided into three groups: Group C (control); Group VS-venom and antivenom; Group VSM-venom, antivenom and aqueous extract of M. glomerata. Crotalic poison caused clinical and laboratory alterations in Wistar mice. Significant clinical alterations were: temperature decrease, edema in the venom inoculated member, sedation and a locomotion decrease in groups VS and VSM when compared with group C. A faster recovery from sedation was observed only for animals of group VSM when compared to VS. There was an increase in the number of leukocytes, neutrophils and creatine kinase in the VS and VSM groups, compared to group C. Wistar rats showed a high resistance to crotalic venom. Additional studies with different doses, time of treatment, different administration methods and histopathological and immunological studies are necessary to understand the action of M. glomerata in crotalic accidents. Rev. Biol. Trop. 57 (4): 929-937. Epub 2009 December 01. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Abstract (Spanish) Group: Ab Data: El envenamiento crotálico representa el número más alto de muertes cuando es comparado con envenenamientos por mordeduras de otras serpientes de interés médico. El veneno crotálico tiene importantes características de acción neurotóxica, miotoxicidad, nefrotoxicidad, coagulación y acción hemolítica. Este trabajo evaluó los aspectos clínicos y de laboratorio del envenenamiento experimental con el veneno de la serpiente Crotalus durissus terrificus en las ratas Wistar tratadas con suero antiofídico y extracto acuoso de M. glomerata. Los animales fueron separados en tres diferentes grupos: grupo control (C); grupo veneno+suero (VS), grupo veneno+suero+extracto acuoso de M. glomerata (VSM). El veneno crotálico causó alteraciones clínicas y diferencias en los análisis sanguíneos practicados a los ratones Wistar evaluados. Las alteraciones clínicas más importantes fueron una disminución de la temperatura, edema en el miembro inoculado de veneno, la sedación y una disminución de la locomoción en los grupos VS y VSM comparado con el grupo C. Una rápida recuperación de la sedación estadísticamente significativa fue observada en los animales del grupo VSM al compararse con los del grupo VS. Los análisis sanguíneos mostraron un aumento en el número de leucocitos, neutrofilos y creatina quinasa en los grupos VS y VSM comparados con el grupo C. Los ratones Wistar mostraron una alta resistencia al veneno del crótalo. Estudios adicionales con variación en las dosis, tiempo de tratamiento, y métodos de administración, así como la realización de estudios histopatológicos e inmunológicos son importantes para comprender la acción de M. glomerata en accidentes crotálicos. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Revista de Biología Tropical is the property of Universidad de Costa Rica and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.15517/rbt.v57i4.5437 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 9 StartPage: 929 Subjects: – SubjectFull: ASTERACEAE Type: general – SubjectFull: CROTALUS Type: general – SubjectFull: VIPERIDAE Type: general – SubjectFull: NEUROTOXICOLOGY Type: general – SubjectFull: NEPHROTOXICOLOGY Type: general – SubjectFull: LEUKOCYTES Type: general Titles: – TitleFull: Effect of Mikania glomerata (Asteraceae) leaf extract combined with anti-venom serum on experimental Crotalus durissus (Squamata: Viperidae) envenomation in rats. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Floriano, Rafael Stuani – PersonEntity: Name: NameFull: Nogueira, Rosa Maria Barilli – PersonEntity: Name: NameFull: Sakate, Michiko – PersonEntity: Name: NameFull: Laposy, Cecília Braga – PersonEntity: Name: NameFull: Pereira da Motta, Yudney – PersonEntity: Name: NameFull: Sangiorgio, Fabíola – PersonEntity: Name: NameFull: Costa David, Heloísa – PersonEntity: Name: NameFull: Nabas, João Marcelo IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 12 Text: dec2009 Type: published Y: 2009 Identifiers: – Type: issn-print Value: 00347744 Numbering: – Type: volume Value: 57 – Type: issue Value: 4 Titles: – TitleFull: Revista de Biología Tropical Type: main |
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