ROL DE LAS CELULAS T REGULATORIAS EN ESCLEROSIS MULTIPLE.
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| Title: | ROL DE LAS CELULAS T REGULATORIAS EN ESCLEROSIS MULTIPLE. |
|---|---|
| Alternate Title: | Role of T-regulatory cells in multiple sclerosis. |
| Authors: | Rojas, Juan Ignacio1 juan.rojas@hospitalitaliano.org.ar, Gonzalez, Sergio J.2, Patrucco, Liliana1, Cristiano, Edgardo1 |
| Source: | Medicina (Buenos Aires). 2010, Vol. 70 Issue 1, p79-86. 8p. 2 Diagrams. |
| Subjects: | MULTIPLE sclerosis, IMMUNOLOGIC diseases, IMMUNOLOGY of inflammation, ANTIGENS, AUTOIMMUNE disease prevention |
| Abstract (English): | Multiple sclerosis (MS) is an autoimmune inflammatory demyelinating disease of the central nervous system (CNS). Most of autoimmune diseases arise by an abnormal activation of the inflammatory response against self-antigens (most of them unknown up to date) as a consequence of dysfunction in peripheral tolerance. Regulatory T-cells are essential for maintaining peripheral tolerance, preventing autoimmune diseases and limiting chronic inflammatory conditions. Based on that knowledge, T-regulatory cells have emerged as a key component of the physiopathology of autoimmune diseases including MS. This review compiles the current knowledge on the role and function of T-regulatory cells in MS, the most prevalent CNS autoimmune disease in humans. [ABSTRACT FROM AUTHOR] |
| Abstract (Spanish): | La esclerosis múltiple (EM) es una enfermedad inflamatoria autoinmune desmielinizante del sistema nervioso central (SNC). La mayoría de las enfermedades autoinmunes se originan por la activación anormal de la respuesta inflamatoria contra auto-antígenos (la mayoría de ellos desconocidos a la fecha) como consecuencia de la pérdida de la tolerancia periférica. Las células T-regulatorias constituyen un grupo esencial de linfocitos T encargados del mantenimiento de la tolerancia periférica, la prevención de enfermedades autoinmunes y la limitación de enfermedades inflamatorias crónicas. Teniendo en cuenta la importancia de la tolerancia periférica, las células T-regulatorias serían componentes cruciales en el escenario fisiopatológico de los procesos autoinmunes, incluyendo la EM. El presente trabajo recopila los conocimientos actuales sobre la función de las células T-regulatorias en la EM, la enfermedad autoinmune desmielinizante del SNC más prevalente en los seres humanos. [ABSTRACT FROM AUTHOR] |
| Copyright of Medicina (Buenos Aires) is the property of Medicina (Buenos Aires) and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | MedicLatina |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: lth DbLabel: MedicLatina An: 52840619 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: ROL DE LAS CELULAS T REGULATORIAS EN ESCLEROSIS MULTIPLE. – Name: TitleAlt Label: Alternate Title Group: TiAlt Data: Role of T-regulatory cells in multiple sclerosis. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Rojas%2C+Juan+Ignacio%22">Rojas, Juan Ignacio</searchLink><relatesTo>1</relatesTo><i> juan.rojas@hospitalitaliano.org.ar</i><br /><searchLink fieldCode="AR" term="%22Gonzalez%2C+Sergio+J%2E%22">Gonzalez, Sergio J.</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Patrucco%2C+Liliana%22">Patrucco, Liliana</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Cristiano%2C+Edgardo%22">Cristiano, Edgardo</searchLink><relatesTo>1</relatesTo> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Medicina+%28Buenos+Aires%29%22">Medicina (Buenos Aires)</searchLink>. 2010, Vol. 70 Issue 1, p79-86. 8p. 2 Diagrams. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22MULTIPLE+sclerosis%22">MULTIPLE sclerosis</searchLink><br /><searchLink fieldCode="DE" term="%22IMMUNOLOGIC+diseases%22">IMMUNOLOGIC diseases</searchLink><br /><searchLink fieldCode="DE" term="%22IMMUNOLOGY+of+inflammation%22">IMMUNOLOGY of inflammation</searchLink><br /><searchLink fieldCode="DE" term="%22ANTIGENS%22">ANTIGENS</searchLink><br /><searchLink fieldCode="DE" term="%22AUTOIMMUNE+disease+prevention%22">AUTOIMMUNE disease prevention</searchLink> – Name: Abstract Label: Abstract (English) Group: Ab Data: Multiple sclerosis (MS) is an autoimmune inflammatory demyelinating disease of the central nervous system (CNS). Most of autoimmune diseases arise by an abnormal activation of the inflammatory response against self-antigens (most of them unknown up to date) as a consequence of dysfunction in peripheral tolerance. Regulatory T-cells are essential for maintaining peripheral tolerance, preventing autoimmune diseases and limiting chronic inflammatory conditions. Based on that knowledge, T-regulatory cells have emerged as a key component of the physiopathology of autoimmune diseases including MS. This review compiles the current knowledge on the role and function of T-regulatory cells in MS, the most prevalent CNS autoimmune disease in humans. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Abstract (Spanish) Group: Ab Data: La esclerosis múltiple (EM) es una enfermedad inflamatoria autoinmune desmielinizante del sistema nervioso central (SNC). La mayoría de las enfermedades autoinmunes se originan por la activación anormal de la respuesta inflamatoria contra auto-antígenos (la mayoría de ellos desconocidos a la fecha) como consecuencia de la pérdida de la tolerancia periférica. Las células T-regulatorias constituyen un grupo esencial de linfocitos T encargados del mantenimiento de la tolerancia periférica, la prevención de enfermedades autoinmunes y la limitación de enfermedades inflamatorias crónicas. Teniendo en cuenta la importancia de la tolerancia periférica, las células T-regulatorias serían componentes cruciales en el escenario fisiopatológico de los procesos autoinmunes, incluyendo la EM. El presente trabajo recopila los conocimientos actuales sobre la función de las células T-regulatorias en la EM, la enfermedad autoinmune desmielinizante del SNC más prevalente en los seres humanos. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Medicina (Buenos Aires) is the property of Medicina (Buenos Aires) and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=lth&AN=52840619 |
| RecordInfo | BibRecord: BibEntity: Languages: – Code: spa Text: Spanish PhysicalDescription: Pagination: PageCount: 8 StartPage: 79 Subjects: – SubjectFull: MULTIPLE sclerosis Type: general – SubjectFull: IMMUNOLOGIC diseases Type: general – SubjectFull: IMMUNOLOGY of inflammation Type: general – SubjectFull: ANTIGENS Type: general – SubjectFull: AUTOIMMUNE disease prevention Type: general Titles: – TitleFull: ROL DE LAS CELULAS T REGULATORIAS EN ESCLEROSIS MULTIPLE. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Rojas, Juan Ignacio – PersonEntity: Name: NameFull: Gonzalez, Sergio J. – PersonEntity: Name: NameFull: Patrucco, Liliana – PersonEntity: Name: NameFull: Cristiano, Edgardo IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 02 Text: 2010 Type: published Y: 2010 Identifiers: – Type: issn-print Value: 00257680 Numbering: – Type: volume Value: 70 – Type: issue Value: 1 Titles: – TitleFull: Medicina (Buenos Aires) Type: main |
| ResultId | 1 |
