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Recurrencia del cáncer papilar de tiroides con tiroidectomía total y terapia adyuvante o con cirugía limitada en grupos de bajo riesgo.

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Title: Recurrencia del cáncer papilar de tiroides con tiroidectomía total y terapia adyuvante o con cirugía limitada en grupos de bajo riesgo.
Authors: Hurtado-López, Luis Mauricio1 hurtado@clinicadetiroides.com.mx, Melchor-Ruan, Javier1, Basurto-Kuba, Erich1, de Oca-Durán, Edgar Rafael Montes1, Pulido-Cejudo, Abraham2, Athié-Gutiérrez, César3
Source: Cirugía y Cirujanos. mar/abr2011, Vol. 79 Issue 2, p118-125. 8p. 4 Charts.
Subjects: THYROID cancer patients, CANCER relapse, CANCER histopathology, THYROIDECTOMY, METASTASIS, ADJUVANT treatment of cancer
Abstract (English): Background: Surgical extension for treatment of patients with low-risk papillary thyroid carcinoma is still controversial. We undertook this study to assess if there is a difference in recurrence between patients undergoing total thyroidectomy plus adjuvant therapy and patients treated with only partial thyroidectomy. Methods: We conducted a longitudinal, observational, analytical study in patients with histopathological diagnosis of low-risk papillary thyroid carcinoma followed for at least 10 years. Patients were divided into two groups: Group 1: Patients treated with total thyroidectomy plus adjuvant therapy (TT) and Group 2: Patients treated with only partial thyroidectomy without adjuvant therapy (HT). Descriptive and inferential statistical methods were used. Results: AMES: 184 patients, recurrence in 5/23 HT and 7/161 TT (p = 0.0016); MACIS: 170 patients, recurrence in 5/24 HT and 5/146 TT (p = 0.0008); DeGroot: 92 patients, recurrence in 3/19 HT and 2/73 TT (p = 0.0254); TNM: 150 patients, recurrence in 5/22 HT and 7/128 TT (p = 0.0058). The time interval for local recurrences was higher in comparison to regional recurrences (p <0.05). In all classifications, recurrences occur mainly with regional metastatic disease (60%). Multifocality, bilateral disease and extracapsular disease showed no statistical difference. There was one incidental injury to a recurrent laryngeal nerve and this was repaired during the same surgical procedure. There was no morbidity due to hypoparathyroidism. Conclusions: Patients classified as low risk according to any of the studied classifications have a higher risk for recurrence when treated with hemithyroidectomy than when treated with total thyroidectomy plus adjuvant therapy. [ABSTRACT FROM AUTHOR]
Abstract (Spanish): Introducción: Existe controversia en la extensión quirúrgica y el tratamiento adyuvante en el carcinoma papilar tiroideo de bajo riesgo. Objetivo: evaluar si en pacientes de bajo riesgo existe diferencia en la recurrencia con tiroidectomía total más adyuvancia y con cirugía limitada. Material y métodos: Estudio longitudinal, observacional, analítico, de 184 pacientes con diagnóstico histopatológico de cáncer papilar de tiroides clasificados como de bajo riesgo por medio de TNM, MACIS, AMES y DeGroot, con un mínimo de 10 años de seguimiento. Los pacientes fueron divididos en dos grupos: uno con tiroidectomía total más tratamiento adyuvante (TT) y otro control con cirugía limitada sin complementación (HT). El análisis se efectuó por medio de estadística descriptiva e inferencial. Resultados: AMES: 184 pacientes, recurrencia en 5/23 HT y 7/161 TT (p = 0.0016). MACIS: 170 pacientes, recurrencia en 5/24 HT y 5/146 TT (p = 0.0008). DeGroot: 92 pacientes, recurrencia en 3/19 HT y 2/73 TT (p = 0.0254). TNM: 150 pacientes, recurrencia en 5/22 HT y 7/128 TT (p = 0.0058). Las recurrencias locales tardaron más tiempo en manifestarse que las regionales (p < 0.05). En todas las clasificaciones la recurrencia se manifiesta predominantemente con metástasis regionales (60%). La multicentricidad, bilateralidad y extensión extracapsular no mostraron diferencia significativa. Se presentó una lesión de nervio laríngeo recurrente incidental, reparada durante el mismo procedimiento; no existió hipoparatiroidismo. Conclusiones: Por cualquier clasificación en pacientes de bajo riesgo existió mayor recurrencia con la hemitiroidectomía que con la tiroidectomía total más adyuvancia. [ABSTRACT FROM AUTHOR]
Copyright of Cirugía y Cirujanos is the property of Publicidad Permanyer SLU and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Recurrencia del c&#225;ncer papilar de tiroides con tiroidectom&#237;a total y terapia adyuvante o con cirug&#237;a limitada en grupos de bajo riesgo.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Hurtado-L&#243;pez%2C+Luis+Mauricio%22&quot;&gt;Hurtado-L&#243;pez, Luis Mauricio&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;i&gt; hurtado@clinicadetiroides.com.mx&lt;/i&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Melchor-Ruan%2C+Javier%22&quot;&gt;Melchor-Ruan, Javier&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Basurto-Kuba%2C+Erich%22&quot;&gt;Basurto-Kuba, Erich&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22de+Oca-Dur&#225;n%2C+Edgar+Rafael+Montes%22&quot;&gt;de Oca-Dur&#225;n, Edgar Rafael Montes&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Pulido-Cejudo%2C+Abraham%22&quot;&gt;Pulido-Cejudo, Abraham&lt;/searchLink&gt;&lt;relatesTo&gt;2&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Athi&#233;-Guti&#233;rrez%2C+C&#233;sar%22&quot;&gt;Athi&#233;-Guti&#233;rrez, C&#233;sar&lt;/searchLink&gt;&lt;relatesTo&gt;3&lt;/relatesTo&gt;
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  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22THYROID+cancer+patients%22&quot;&gt;THYROID cancer patients&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22CANCER+relapse%22&quot;&gt;CANCER relapse&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22CANCER+histopathology%22&quot;&gt;CANCER histopathology&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22THYROIDECTOMY%22&quot;&gt;THYROIDECTOMY&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22METASTASIS%22&quot;&gt;METASTASIS&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22ADJUVANT+treatment+of+cancer%22&quot;&gt;ADJUVANT treatment of cancer&lt;/searchLink&gt;
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  Group: Ab
  Data: Background: Surgical extension for treatment of patients with low-risk papillary thyroid carcinoma is still controversial. We undertook this study to assess if there is a difference in recurrence between patients undergoing total thyroidectomy plus adjuvant therapy and patients treated with only partial thyroidectomy. Methods: We conducted a longitudinal, observational, analytical study in patients with histopathological diagnosis of low-risk papillary thyroid carcinoma followed for at least 10 years. Patients were divided into two groups: Group 1: Patients treated with total thyroidectomy plus adjuvant therapy (TT) and Group 2: Patients treated with only partial thyroidectomy without adjuvant therapy (HT). Descriptive and inferential statistical methods were used. Results: AMES: 184 patients, recurrence in 5/23 HT and 7/161 TT (p = 0.0016); MACIS: 170 patients, recurrence in 5/24 HT and 5/146 TT (p = 0.0008); DeGroot: 92 patients, recurrence in 3/19 HT and 2/73 TT (p = 0.0254); TNM: 150 patients, recurrence in 5/22 HT and 7/128 TT (p = 0.0058). The time interval for local recurrences was higher in comparison to regional recurrences (p &lt;0.05). In all classifications, recurrences occur mainly with regional metastatic disease (60%). Multifocality, bilateral disease and extracapsular disease showed no statistical difference. There was one incidental injury to a recurrent laryngeal nerve and this was repaired during the same surgical procedure. There was no morbidity due to hypoparathyroidism. Conclusions: Patients classified as low risk according to any of the studied classifications have a higher risk for recurrence when treated with hemithyroidectomy than when treated with total thyroidectomy plus adjuvant therapy. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label: Abstract (Spanish)
  Group: Ab
  Data: Introducci&#243;n: Existe controversia en la extensi&#243;n quir&#250;rgica y el tratamiento adyuvante en el carcinoma papilar tiroideo de bajo riesgo. Objetivo: evaluar si en pacientes de bajo riesgo existe diferencia en la recurrencia con tiroidectom&#237;a total m&#225;s adyuvancia y con cirug&#237;a limitada. Material y m&#233;todos: Estudio longitudinal, observacional, anal&#237;tico, de 184 pacientes con diagn&#243;stico histopatol&#243;gico de c&#225;ncer papilar de tiroides clasificados como de bajo riesgo por medio de TNM, MACIS, AMES y DeGroot, con un m&#237;nimo de 10 a&#241;os de seguimiento. Los pacientes fueron divididos en dos grupos: uno con tiroidectom&#237;a total m&#225;s tratamiento adyuvante (TT) y otro control con cirug&#237;a limitada sin complementaci&#243;n (HT). El an&#225;lisis se efectu&#243; por medio de estad&#237;stica descriptiva e inferencial. Resultados: AMES: 184 pacientes, recurrencia en 5/23 HT y 7/161 TT (p = 0.0016). MACIS: 170 pacientes, recurrencia en 5/24 HT y 5/146 TT (p = 0.0008). DeGroot: 92 pacientes, recurrencia en 3/19 HT y 2/73 TT (p = 0.0254). TNM: 150 pacientes, recurrencia en 5/22 HT y 7/128 TT (p = 0.0058). Las recurrencias locales tardaron m&#225;s tiempo en manifestarse que las regionales (p &lt; 0.05). En todas las clasificaciones la recurrencia se manifiesta predominantemente con met&#225;stasis regionales (60%). La multicentricidad, bilateralidad y extensi&#243;n extracapsular no mostraron diferencia significativa. Se present&#243; una lesi&#243;n de nervio lar&#237;ngeo recurrente incidental, reparada durante el mismo procedimiento; no existi&#243; hipoparatiroidismo. Conclusiones: Por cualquier clasificaci&#243;n en pacientes de bajo riesgo existi&#243; mayor recurrencia con la hemitiroidectom&#237;a que con la tiroidectom&#237;a total m&#225;s adyuvancia. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of Cirug&#237;a y Cirujanos is the property of Publicidad Permanyer SLU and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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      – Code: spa
        Text: Spanish
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        PageCount: 8
        StartPage: 118
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      – SubjectFull: THYROID cancer patients
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      – SubjectFull: CANCER relapse
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      – TitleFull: Recurrencia del cáncer papilar de tiroides con tiroidectomía total y terapia adyuvante o con cirugía limitada en grupos de bajo riesgo.
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