Malaria en humanos por infección natural con Plasmodium knowlesi.
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| Title: | Malaria en humanos por infección natural con Plasmodium knowlesi. |
|---|---|
| Alternate Title: | Natural Plasmodium knowlesi malaria infections in humans. |
| Authors: | Martínez-Salazar, Edgar1,2, Tobón-Castaño, Alberto1,2, Blair, Silvia1 |
| Source: | Biomédica: Revista del Instituto Nacional de Salud. abr2012 supplement, Vol. 32, p121-130. 10p. |
| Subjects: | PLASMODIUM, MALARIA, EPIDEMIOLOGY, INFECTION, HUMAN beings |
| Geographic Terms: | SOUTHEAST Asia |
| Abstract (English): | The first reported case of natural transmission of Plasmodium knowlesi to humans was published in 1965. In Southeast Asia, the atypical presentation of malaria cases, the changes in the distribution of the Plasmodium species diagnosed and their atypical morphology prompted several studies that confirmed natural infections in humans by this protozoon which naturally infects different species of apes which are endemic in the forests of this region. Recent studies suggest that P. knowlesi malaria is not an emerging disease in humans but was rather being misdiagnosed due to its morphological similarity with P. malariae and P. falciparum, hampering its correct diagnosis by microscopic examination. Currently, the diagnosis can be confirmed by polymerase chain reaction using P. knowlesi specific primers. Malaria by P. knowlesi has lead to fatal outcomes in humans and poses several challenges such as the development of useful diagnostic tools for endemic areas, the study of the vectors involved and the therapeutic efficacy of the drugs for its treatment. In the jungle regions of South America it is imperative to monitor the parasites of simian malaria and the vectors that have the potential to transmit this zoonosis. [ABSTRACT FROM AUTHOR] |
| Abstract (Spanish): | El primer caso informado de transmisión natural de Plasmodium knowlesi en humanos se publicó en 1965. En el sureste de Asia la presentación atípica de casos de malaria, tanto por cambios en la distribución de las especies diagnosticadas de Plasmodium, como por su morfología, motivó diversos estudios que han confirmado la infección en humanos por este plasmodio que infecta naturalmente distintas especies de simios, que son endémicos de las selvas de esta región. Los estudios recientes sugieren que la malaria por P. knowlesi no es una enfermedad emergente en humanos sino que no estaba siendo diagnosticada, debido a la similitud morfológica de este plasmodio con P. malariae y P. falciparum, lo cual dificulta su reconocimiento mediante examen microscópico. Actualmente, se puede confirmar el diagnóstico mediante reacción en cadena de la polimerasa que permite identificar cebadores específicos de P. knowlesi. La malaria por P. knowlesi ha ocasionado desenlaces fatales en humanos, lo que plantea diversos retos como la búsqueda de métodos operativos de diagnóstico para las zonas endémicas, el estudio de los vectores involucrados y la eficacia terapéutica de los medicamentos para su tratamiento. En las regiones selváticas de Suramérica se hace imperativa la vigilancia de parásitos y vectores de la malaria en simios, que potencialmente puedan ocasionar esta zoonosis. [ABSTRACT FROM AUTHOR] |
| Copyright of Biomédica: Revista del Instituto Nacional de Salud is the property of Instituto Nacional de Salud of Colombia and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | MedicLatina |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: lth DbLabel: MedicLatina An: 75274522 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Malaria en humanos por infección natural con Plasmodium knowlesi. – Name: TitleAlt Label: Alternate Title Group: TiAlt Data: Natural Plasmodium knowlesi malaria infections in humans. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Martínez-Salazar%2C+Edgar%22">Martínez-Salazar, Edgar</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Tobón-Castaño%2C+Alberto%22">Tobón-Castaño, Alberto</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Blair%2C+Silvia%22">Blair, Silvia</searchLink><relatesTo>1</relatesTo> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Biomédica%3A+Revista+del+Instituto+Nacional+de+Salud%22">Biomédica: Revista del Instituto Nacional de Salud</searchLink>. abr2012 supplement, Vol. 32, p121-130. 10p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22PLASMODIUM%22">PLASMODIUM</searchLink><br /><searchLink fieldCode="DE" term="%22MALARIA%22">MALARIA</searchLink><br /><searchLink fieldCode="DE" term="%22EPIDEMIOLOGY%22">EPIDEMIOLOGY</searchLink><br /><searchLink fieldCode="DE" term="%22INFECTION%22">INFECTION</searchLink><br /><searchLink fieldCode="DE" term="%22HUMAN+beings%22">HUMAN beings</searchLink> – Name: SubjectGeographic Label: Geographic Terms Group: Su Data: <searchLink fieldCode="DE" term="%22SOUTHEAST+Asia%22">SOUTHEAST Asia</searchLink> – Name: Abstract Label: Abstract (English) Group: Ab Data: The first reported case of natural transmission of Plasmodium knowlesi to humans was published in 1965. In Southeast Asia, the atypical presentation of malaria cases, the changes in the distribution of the Plasmodium species diagnosed and their atypical morphology prompted several studies that confirmed natural infections in humans by this protozoon which naturally infects different species of apes which are endemic in the forests of this region. Recent studies suggest that P. knowlesi malaria is not an emerging disease in humans but was rather being misdiagnosed due to its morphological similarity with P. malariae and P. falciparum, hampering its correct diagnosis by microscopic examination. Currently, the diagnosis can be confirmed by polymerase chain reaction using P. knowlesi specific primers. Malaria by P. knowlesi has lead to fatal outcomes in humans and poses several challenges such as the development of useful diagnostic tools for endemic areas, the study of the vectors involved and the therapeutic efficacy of the drugs for its treatment. In the jungle regions of South America it is imperative to monitor the parasites of simian malaria and the vectors that have the potential to transmit this zoonosis. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Abstract (Spanish) Group: Ab Data: El primer caso informado de transmisión natural de Plasmodium knowlesi en humanos se publicó en 1965. En el sureste de Asia la presentación atípica de casos de malaria, tanto por cambios en la distribución de las especies diagnosticadas de Plasmodium, como por su morfología, motivó diversos estudios que han confirmado la infección en humanos por este plasmodio que infecta naturalmente distintas especies de simios, que son endémicos de las selvas de esta región. Los estudios recientes sugieren que la malaria por P. knowlesi no es una enfermedad emergente en humanos sino que no estaba siendo diagnosticada, debido a la similitud morfológica de este plasmodio con P. malariae y P. falciparum, lo cual dificulta su reconocimiento mediante examen microscópico. Actualmente, se puede confirmar el diagnóstico mediante reacción en cadena de la polimerasa que permite identificar cebadores específicos de P. knowlesi. La malaria por P. knowlesi ha ocasionado desenlaces fatales en humanos, lo que plantea diversos retos como la búsqueda de métodos operativos de diagnóstico para las zonas endémicas, el estudio de los vectores involucrados y la eficacia terapéutica de los medicamentos para su tratamiento. En las regiones selváticas de Suramérica se hace imperativa la vigilancia de parásitos y vectores de la malaria en simios, que potencialmente puedan ocasionar esta zoonosis. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Biomédica: Revista del Instituto Nacional de Salud is the property of Instituto Nacional de Salud of Colombia and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 10 StartPage: 121 Subjects: – SubjectFull: PLASMODIUM Type: general – SubjectFull: MALARIA Type: general – SubjectFull: EPIDEMIOLOGY Type: general – SubjectFull: INFECTION Type: general – SubjectFull: HUMAN beings Type: general – SubjectFull: SOUTHEAST Asia Type: general Titles: – TitleFull: Malaria en humanos por infección natural con Plasmodium knowlesi. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Martínez-Salazar, Edgar – PersonEntity: Name: NameFull: Tobón-Castaño, Alberto – PersonEntity: Name: NameFull: Blair, Silvia IsPartOfRelationships: – BibEntity: Dates: – D: 02 M: 04 Text: abr2012 supplement Type: published Y: 2012 Identifiers: – Type: issn-print Value: 01204157 Numbering: – Type: volume Value: 32 Titles: – TitleFull: Biomédica: Revista del Instituto Nacional de Salud Type: main |
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