El cultivo de precursores neuronales del epitelio olfatorio: Un modelo para estudiar la neurofisiopatología de la esquizofrenia.
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| Title: | El cultivo de precursores neuronales del epitelio olfatorio: Un modelo para estudiar la neurofisiopatología de la esquizofrenia. |
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| Alternate Title: | The culture of olfactory epithelium neuronal precursors: A model for studying schizophrenia neurophysiopathology. |
| Authors: | Solís-Chagoyán, Héctor1, Domínguez-Alonso, Aline1, Calixto, Eduardo2, Benítez-King, Gloria1 bekin@imp.edu.mx |
| Source: | Salud Mental. may/jun2012, Vol. 35 Issue 3, p241-246. 6p. 1 Black and White Photograph, 1 Diagram. |
| Subjects: | PEOPLE with schizophrenia, SCHIZOPHRENIA -- Physiological aspects, SMELL disorders, MENTAL illness, PATHOLOGICAL physiology, NEUROLOGICAL research, DEVELOPMENTAL neurobiology, PHYSIOLOGY |
| Abstract (English): | Schizophrenia is a mental disorder characterized by delusions, hallucinations, disorganization in speech and thinking as well as alterations in social behavior, and affective flattening. Schizophrenic patients also have an olfactory deficit since prodromal stages of this disorder. The olfactory deficit could be present in schizophrenic patients due to anatomic and structural alteration of the Central Nervous System, or peripheral abnormalities in the olfactory epithelium. The major alterations of the Central Nervous System are diminished volumes of olfactory bulb and structures of primary olfactory cortex, hippocampus and amygdala. While, olfactory epithelium has functional abnormalities in cellular differentiation and electric response of sensory olfactory neurons, which suggest an impairment of the odor transduction. The cellular culture of olfactory epithelium has allowed isolating multipotential progenitor cells that have the ability to proliferate and differentiate in mature neurons and glia. This model could provide evidences on the causes that could explain the olfactory deficits in schizophrenia. Moreover, it will allow testing hypothesis on pathophysiological causes of this mental disorder in different of stages of the neurodevelopment. In addition, olfactory epithelial neuronal precursors constitute a novel model to detect genetic, proteomic and functional biomarkers that allow a biological diagnosis. [ABSTRACT FROM AUTHOR] |
| Abstract (Spanish): | La esquizofrenia (EZ) es un trastorno psiquiátrico que se caracteriza por la presencia de delirios, alucinaciones, pensamiento desorganizado, lenguaje desestructurado, alteraciones del comportamiento social y aplanamiento afectivo, entre otros síntomas. Los pacientes con EZ también presentan un déficit en la capacidad olfatoria desde la fase prodrómica del trastorno. El déficit olfatorio en la EZ puede presentarse por alteraciones anatómico-estructurales del SNC o por anomalías a nivel periférico en el epitelio olfatorio. Las alteraciones principales del SNC son la disminución del volumen de los bulbos olfatorios, de estructuras de la corteza olfatoria primaria, del hipocampo y de la amígdala coronal. El epitelio olfatorio en los estadios tempranos de la EZ presenta anomalías funcionales en la diferenciación y en la respuesta biofísica de las neuronas sensoriales olfatorias, lo que sugiere que existe un desacoplamiento de la transducción olfatoria. El cultivo celular del epitelio olfatorio ha permitido aislar células progenitoras multipotenciales que poseen la capacidad de proliferar y diferenciarse en neuronas y glía. El estudio de este modelo podría aportar evidencia sobre las causas que explicarían el déficit olfatorio en la esquizofrenia y permitiría estudiar hipótesis que intenten explicar las causas de la fisiopatología de este trastorno en el neurodesarrollo así como detectar bíomarcadores genéticos, proteómicos o funcionales que permitan un diagnóstico biológico. [ABSTRACT FROM AUTHOR] |
| Copyright of Salud Mental is the property of Instituto Nacional de Psiquiatria Ramon de la Fuente and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | MedicLatina |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: lth DbLabel: MedicLatina An: 78554801 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: El cultivo de precursores neuronales del epitelio olfatorio: Un modelo para estudiar la neurofisiopatología de la esquizofrenia. – Name: TitleAlt Label: Alternate Title Group: TiAlt Data: The culture of olfactory epithelium neuronal precursors: A model for studying schizophrenia neurophysiopathology. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Solís-Chagoyán%2C+Héctor%22">Solís-Chagoyán, Héctor</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Domínguez-Alonso%2C+Aline%22">Domínguez-Alonso, Aline</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Calixto%2C+Eduardo%22">Calixto, Eduardo</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Benítez-King%2C+Gloria%22">Benítez-King, Gloria</searchLink><relatesTo>1</relatesTo><i> bekin@imp.edu.mx</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Salud+Mental%22">Salud Mental</searchLink>. may/jun2012, Vol. 35 Issue 3, p241-246. 6p. 1 Black and White Photograph, 1 Diagram. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22PEOPLE+with+schizophrenia%22">PEOPLE with schizophrenia</searchLink><br /><searchLink fieldCode="DE" term="%22SCHIZOPHRENIA+--+Physiological+aspects%22">SCHIZOPHRENIA -- Physiological aspects</searchLink><br /><searchLink fieldCode="DE" term="%22SMELL+disorders%22">SMELL disorders</searchLink><br /><searchLink fieldCode="DE" term="%22MENTAL+illness%22">MENTAL illness</searchLink><br /><searchLink fieldCode="DE" term="%22PATHOLOGICAL+physiology%22">PATHOLOGICAL physiology</searchLink><br /><searchLink fieldCode="DE" term="%22NEUROLOGICAL+research%22">NEUROLOGICAL research</searchLink><br /><searchLink fieldCode="DE" term="%22DEVELOPMENTAL+neurobiology%22">DEVELOPMENTAL neurobiology</searchLink><br /><searchLink fieldCode="DE" term="%22PHYSIOLOGY%22">PHYSIOLOGY</searchLink> – Name: Abstract Label: Abstract (English) Group: Ab Data: Schizophrenia is a mental disorder characterized by delusions, hallucinations, disorganization in speech and thinking as well as alterations in social behavior, and affective flattening. Schizophrenic patients also have an olfactory deficit since prodromal stages of this disorder. The olfactory deficit could be present in schizophrenic patients due to anatomic and structural alteration of the Central Nervous System, or peripheral abnormalities in the olfactory epithelium. The major alterations of the Central Nervous System are diminished volumes of olfactory bulb and structures of primary olfactory cortex, hippocampus and amygdala. While, olfactory epithelium has functional abnormalities in cellular differentiation and electric response of sensory olfactory neurons, which suggest an impairment of the odor transduction. The cellular culture of olfactory epithelium has allowed isolating multipotential progenitor cells that have the ability to proliferate and differentiate in mature neurons and glia. This model could provide evidences on the causes that could explain the olfactory deficits in schizophrenia. Moreover, it will allow testing hypothesis on pathophysiological causes of this mental disorder in different of stages of the neurodevelopment. In addition, olfactory epithelial neuronal precursors constitute a novel model to detect genetic, proteomic and functional biomarkers that allow a biological diagnosis. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Abstract (Spanish) Group: Ab Data: La esquizofrenia (EZ) es un trastorno psiquiátrico que se caracteriza por la presencia de delirios, alucinaciones, pensamiento desorganizado, lenguaje desestructurado, alteraciones del comportamiento social y aplanamiento afectivo, entre otros síntomas. Los pacientes con EZ también presentan un déficit en la capacidad olfatoria desde la fase prodrómica del trastorno. El déficit olfatorio en la EZ puede presentarse por alteraciones anatómico-estructurales del SNC o por anomalías a nivel periférico en el epitelio olfatorio. Las alteraciones principales del SNC son la disminución del volumen de los bulbos olfatorios, de estructuras de la corteza olfatoria primaria, del hipocampo y de la amígdala coronal. El epitelio olfatorio en los estadios tempranos de la EZ presenta anomalías funcionales en la diferenciación y en la respuesta biofísica de las neuronas sensoriales olfatorias, lo que sugiere que existe un desacoplamiento de la transducción olfatoria. El cultivo celular del epitelio olfatorio ha permitido aislar células progenitoras multipotenciales que poseen la capacidad de proliferar y diferenciarse en neuronas y glía. El estudio de este modelo podría aportar evidencia sobre las causas que explicarían el déficit olfatorio en la esquizofrenia y permitiría estudiar hipótesis que intenten explicar las causas de la fisiopatología de este trastorno en el neurodesarrollo así como detectar bíomarcadores genéticos, proteómicos o funcionales que permitan un diagnóstico biológico. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Salud Mental is the property of Instituto Nacional de Psiquiatria Ramon de la Fuente and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Languages: – Code: spa Text: Spanish PhysicalDescription: Pagination: PageCount: 6 StartPage: 241 Subjects: – SubjectFull: PEOPLE with schizophrenia Type: general – SubjectFull: SCHIZOPHRENIA -- Physiological aspects Type: general – SubjectFull: SMELL disorders Type: general – SubjectFull: MENTAL illness Type: general – SubjectFull: PATHOLOGICAL physiology Type: general – SubjectFull: NEUROLOGICAL research Type: general – SubjectFull: DEVELOPMENTAL neurobiology Type: general – SubjectFull: PHYSIOLOGY Type: general Titles: – TitleFull: El cultivo de precursores neuronales del epitelio olfatorio: Un modelo para estudiar la neurofisiopatología de la esquizofrenia. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Solís-Chagoyán, Héctor – PersonEntity: Name: NameFull: Domínguez-Alonso, Aline – PersonEntity: Name: NameFull: Calixto, Eduardo – PersonEntity: Name: NameFull: Benítez-King, Gloria IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 05 Text: may/jun2012 Type: published Y: 2012 Identifiers: – Type: issn-print Value: 01853325 Numbering: – Type: volume Value: 35 – Type: issue Value: 3 Titles: – TitleFull: Salud Mental Type: main |
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