View in EDS

Principios básicos de las nuevas estrategias farmacológicas antiarrítmicas en fibrilación auricular.

Saved in:
Bibliographic Details
Title: Principios básicos de las nuevas estrategias farmacológicas antiarrítmicas en fibrilación auricular.
Alternate Title: Basic mechanisms of the new antiarrhythmic drugs in atrial fibrillation.
Authors: Filgueiras-Rama, David1,2 david.filgueiras@salud.madrid.org, Castrejón, Sergio1, Calvo, Conrado2, Estrada, Alejandro1, Doiny, David1, Ortega, Marta1, Berenfeld, Omer2, Merino, José L.1, Jalife, José2
Source: Archivos de Cardiología de México. abr-jun2012, Vol. 82 Issue 2, p139-152. 14p. 5 Diagrams, 2 Charts, 1 Graph.
Subjects: MYOCARDIAL depressants, ATRIAL fibrillation treatment, ARRHYTHMIA, DRUG development, ROTORS
Geographic Terms: SPAIN
Abstract (English): Atrial fibrillation (AF) is the most common sustained arrhythmia seen in clinical practice. Despite of new technological breakthroughs and the understanding of the mechanisms underlying AF, based on animal models and ablation procedures in patients, the antiarrhythmic drugs remain the main therapeutic strategy to restore and maintain the sinus rhythm. New antiarrhythmic drugs are already available in the clinical practice and many others are under development. The new antiarrhythmic drugs have the capability to block atrial-specific ionic currents, which are involved in the maintenance of the arrhythmia. Parallel, increasing evidence supports the use of compounds to regulate the arrhythmogenic atrial substrate involved in the long-term maintenance of the arrhythmia (upstream therapies). This article reviews the new antiarrhythmic drugs and upstream therapies, based on the current knowledge of the mechanisms involved in the maintenance of AF. [ABSTRACT FROM AUTHOR]
Abstract (Spanish): La fibrilación auricular (FA) es la arritmia crónica sostenida más frecuente en la población general. A pesar de los últimos avances tecnológicos y en el entendimiento de sus mecanismos, derivados de modelos experimentales, así como de los procedimientos de ablación en pacientes con FA, los fármacos antiarrítmicos siguen siendo la principal estrategia para la cardioversión y mantenimiento del ritmo sinusal. Nuevas generaciones de fármacos antiarrítmicos han llegado a la práctica clínica, y otros se encuentran en fase de experimentación. Los nuevos fármacos actúan de forma más específica sobre corrientes iónicas auriculares, y al mismo tiempo involucradas en el mantenimiento de la arritmia. Paralelamente, cada vez se da más importancia a la necesidad de actuar sobre el sustrato arritmogénico auricular y los factores que lo promueven, implicados en el mantenimiento a largo plazo de la arritmia (terapias upstream). La presente revisión tiene como objetivo exponer las actuales líneas de desarrollo en fármacos antiarrítmicos y terapias para prevención o retraso del remodelado auricular, con base a los conocimientos mecanísticos que hoy en día se involucran en el mantenimiento de la FA. [ABSTRACT FROM AUTHOR]
Copyright of Archivos de Cardiología de México is the property of Publicidad Permanyer SLU and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: MedicLatina
FullText Text:
  Availability: 0
Header DbId: lth
DbLabel: MedicLatina
An: 82831421
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Principios básicos de las nuevas estrategias farmacológicas antiarrítmicas en fibrilación auricular.
– Name: TitleAlt
  Label: Alternate Title
  Group: TiAlt
  Data: Basic mechanisms of the new antiarrhythmic drugs in atrial fibrillation.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Filgueiras-Rama%2C+David%22">Filgueiras-Rama, David</searchLink><relatesTo>1,2</relatesTo><i> david.filgueiras@salud.madrid.org</i><br /><searchLink fieldCode="AR" term="%22Castrejón%2C+Sergio%22">Castrejón, Sergio</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Calvo%2C+Conrado%22">Calvo, Conrado</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Estrada%2C+Alejandro%22">Estrada, Alejandro</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Doiny%2C+David%22">Doiny, David</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Ortega%2C+Marta%22">Ortega, Marta</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Berenfeld%2C+Omer%22">Berenfeld, Omer</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Merino%2C+José+L%2E%22">Merino, José L.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Jalife%2C+José%22">Jalife, José</searchLink><relatesTo>2</relatesTo>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Archivos+de+Cardiología+de+México%22">Archivos de Cardiología de México</searchLink>. abr-jun2012, Vol. 82 Issue 2, p139-152. 14p. 5 Diagrams, 2 Charts, 1 Graph.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22MYOCARDIAL+depressants%22">MYOCARDIAL depressants</searchLink><br /><searchLink fieldCode="DE" term="%22ATRIAL+fibrillation+treatment%22">ATRIAL fibrillation treatment</searchLink><br /><searchLink fieldCode="DE" term="%22ARRHYTHMIA%22">ARRHYTHMIA</searchLink><br /><searchLink fieldCode="DE" term="%22DRUG+development%22">DRUG development</searchLink><br /><searchLink fieldCode="DE" term="%22ROTORS%22">ROTORS</searchLink>
– Name: SubjectGeographic
  Label: Geographic Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22SPAIN%22">SPAIN</searchLink>
– Name: Abstract
  Label: Abstract (English)
  Group: Ab
  Data: Atrial fibrillation (AF) is the most common sustained arrhythmia seen in clinical practice. Despite of new technological breakthroughs and the understanding of the mechanisms underlying AF, based on animal models and ablation procedures in patients, the antiarrhythmic drugs remain the main therapeutic strategy to restore and maintain the sinus rhythm. New antiarrhythmic drugs are already available in the clinical practice and many others are under development. The new antiarrhythmic drugs have the capability to block atrial-specific ionic currents, which are involved in the maintenance of the arrhythmia. Parallel, increasing evidence supports the use of compounds to regulate the arrhythmogenic atrial substrate involved in the long-term maintenance of the arrhythmia (upstream therapies). This article reviews the new antiarrhythmic drugs and upstream therapies, based on the current knowledge of the mechanisms involved in the maintenance of AF. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label: Abstract (Spanish)
  Group: Ab
  Data: La fibrilación auricular (FA) es la arritmia crónica sostenida más frecuente en la población general. A pesar de los últimos avances tecnológicos y en el entendimiento de sus mecanismos, derivados de modelos experimentales, así como de los procedimientos de ablación en pacientes con FA, los fármacos antiarrítmicos siguen siendo la principal estrategia para la cardioversión y mantenimiento del ritmo sinusal. Nuevas generaciones de fármacos antiarrítmicos han llegado a la práctica clínica, y otros se encuentran en fase de experimentación. Los nuevos fármacos actúan de forma más específica sobre corrientes iónicas auriculares, y al mismo tiempo involucradas en el mantenimiento de la arritmia. Paralelamente, cada vez se da más importancia a la necesidad de actuar sobre el sustrato arritmogénico auricular y los factores que lo promueven, implicados en el mantenimiento a largo plazo de la arritmia (terapias upstream). La presente revisión tiene como objetivo exponer las actuales líneas de desarrollo en fármacos antiarrítmicos y terapias para prevención o retraso del remodelado auricular, con base a los conocimientos mecanísticos que hoy en día se involucran en el mantenimiento de la FA. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Archivos de Cardiología de México is the property of Publicidad Permanyer SLU and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=lth&AN=82831421
RecordInfo BibRecord:
  BibEntity:
    Languages:
      – Code: spa
        Text: Spanish
    PhysicalDescription:
      Pagination:
        PageCount: 14
        StartPage: 139
    Subjects:
      – SubjectFull: MYOCARDIAL depressants
        Type: general
      – SubjectFull: ATRIAL fibrillation treatment
        Type: general
      – SubjectFull: ARRHYTHMIA
        Type: general
      – SubjectFull: DRUG development
        Type: general
      – SubjectFull: ROTORS
        Type: general
      – SubjectFull: SPAIN
        Type: general
    Titles:
      – TitleFull: Principios básicos de las nuevas estrategias farmacológicas antiarrítmicas en fibrilación auricular.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Filgueiras-Rama, David
      – PersonEntity:
          Name:
            NameFull: Castrejón, Sergio
      – PersonEntity:
          Name:
            NameFull: Calvo, Conrado
      – PersonEntity:
          Name:
            NameFull: Estrada, Alejandro
      – PersonEntity:
          Name:
            NameFull: Doiny, David
      – PersonEntity:
          Name:
            NameFull: Ortega, Marta
      – PersonEntity:
          Name:
            NameFull: Berenfeld, Omer
      – PersonEntity:
          Name:
            NameFull: Merino, José L.
      – PersonEntity:
          Name:
            NameFull: Jalife, José
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 04
              Text: abr-jun2012
              Type: published
              Y: 2012
          Identifiers:
            – Type: issn-print
              Value: 14059940
          Numbering:
            – Type: volume
              Value: 82
            – Type: issue
              Value: 2
          Titles:
            – TitleFull: Archivos de Cardiología de México
              Type: main
ResultId 1