Variaciones alélicas en los genes de citocinas proinflamatorias y antiinflamatorias, y su asociación con la susceptibilidad y el curso clínico de la sepsis.
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| Title: | Variaciones alélicas en los genes de citocinas proinflamatorias y antiinflamatorias, y su asociación con la susceptibilidad y el curso clínico de la sepsis. |
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| Alternate Title: | Allelic variations in genes of pro-inflammatory and anti-inflammatory cytokines, and their association with the susceptibility to sepsis and its clinical course. |
| Authors: | Montoya Ruiz, Carolina1 carolinamontoyaruiz@gmail.com, Rugeles López, María Teresa2, Jaimes Barragán, Fabián Alberto3, Velilla Hernández, Paula Andrea4 |
| Source: | Iatreia. ene-mar2013, Vol. 26 Issue 1, p67-76. 10p. |
| Subjects: | SEPSIS, ANTI-inflammatory agents, CYTOKINES, GENETIC polymorphisms, GENE expression |
| Abstract (English): | Sepsis is the main cause of mortality in intensive care units. Therefore, many efforts to develop therapeutic approaches have been made without significant progress. The balance between the pro-inflammatory and anti-inflammatory responses during the course of sepsis may determine the clinical outcome of patients; besides, the complexity of developing successful treatments in sepsis may be related to the heterogeneous nature of immune responses; the importance of genetic factors that regulate the immune component during the inflammatory response is emphasized. Based on such facts, this review focuses on genes of cytokines involved in the clinical course of sepsis; on information about their allelic variants found in the population with sepsis, and on their impact on gene expression. These factors are of critical importance, and a better knowledge about them could help to evaluate the risk of developing sepsis, and to define their association with the clinical evolution of this syndrome. [ABSTRACT FROM AUTHOR] |
| Abstract (Spanish): | Se considera que la sepsis es la principal causa de mortalidad en las unidades de cuidado intensivo, por lo cual ha sido objeto de numerosas investigaciones que aún no se han traducido en avances terapéuticos significativos. El balance entre los fenómenos proinflamatorios y antiinflamatorios característicos de este síndrome es el que puede determinar el desenlace del paciente; además, la complejidad del desarrollo de estrategias terapéuticas en sepsis está relacionada con la naturaleza heterogénea de la respuesta inmune; se destaca la importancia de los factores genéticos que regulan el componente inmune durante la respuesta inflamatoria. Con base en tales conocimientos, esta revisión se centra en genes de citocinas importantes en el curso clínico de la sepsis, en la información sobre sus variantes genéticas en la población con sepsis y en su impacto sobre la función del gen. Estos factores son de importancia crítica y un mejor conocimiento acerca de ellos podría ayudar a evaluar el riesgo de desarrollar sepsis y a definir su asociación con la evolución clínica de este síndrome. [ABSTRACT FROM AUTHOR] |
| Copyright of Iatreia is the property of Universidad de Antioquia and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | MedicLatina |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: lth DbLabel: MedicLatina An: 85102234 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Variaciones alélicas en los genes de citocinas proinflamatorias y antiinflamatorias, y su asociación con la susceptibilidad y el curso clínico de la sepsis. – Name: TitleAlt Label: Alternate Title Group: TiAlt Data: Allelic variations in genes of pro-inflammatory and anti-inflammatory cytokines, and their association with the susceptibility to sepsis and its clinical course. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Montoya+Ruiz%2C+Carolina%22">Montoya Ruiz, Carolina</searchLink><relatesTo>1</relatesTo><i> carolinamontoyaruiz@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Rugeles+López%2C+María+Teresa%22">Rugeles López, María Teresa</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Jaimes+Barragán%2C+Fabián+Alberto%22">Jaimes Barragán, Fabián Alberto</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Velilla+Hernández%2C+Paula+Andrea%22">Velilla Hernández, Paula Andrea</searchLink><relatesTo>4</relatesTo> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Iatreia%22">Iatreia</searchLink>. ene-mar2013, Vol. 26 Issue 1, p67-76. 10p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22SEPSIS%22">SEPSIS</searchLink><br /><searchLink fieldCode="DE" term="%22ANTI-inflammatory+agents%22">ANTI-inflammatory agents</searchLink><br /><searchLink fieldCode="DE" term="%22CYTOKINES%22">CYTOKINES</searchLink><br /><searchLink fieldCode="DE" term="%22GENETIC+polymorphisms%22">GENETIC polymorphisms</searchLink><br /><searchLink fieldCode="DE" term="%22GENE+expression%22">GENE expression</searchLink> – Name: Abstract Label: Abstract (English) Group: Ab Data: Sepsis is the main cause of mortality in intensive care units. Therefore, many efforts to develop therapeutic approaches have been made without significant progress. The balance between the pro-inflammatory and anti-inflammatory responses during the course of sepsis may determine the clinical outcome of patients; besides, the complexity of developing successful treatments in sepsis may be related to the heterogeneous nature of immune responses; the importance of genetic factors that regulate the immune component during the inflammatory response is emphasized. Based on such facts, this review focuses on genes of cytokines involved in the clinical course of sepsis; on information about their allelic variants found in the population with sepsis, and on their impact on gene expression. These factors are of critical importance, and a better knowledge about them could help to evaluate the risk of developing sepsis, and to define their association with the clinical evolution of this syndrome. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Abstract (Spanish) Group: Ab Data: Se considera que la sepsis es la principal causa de mortalidad en las unidades de cuidado intensivo, por lo cual ha sido objeto de numerosas investigaciones que aún no se han traducido en avances terapéuticos significativos. El balance entre los fenómenos proinflamatorios y antiinflamatorios característicos de este síndrome es el que puede determinar el desenlace del paciente; además, la complejidad del desarrollo de estrategias terapéuticas en sepsis está relacionada con la naturaleza heterogénea de la respuesta inmune; se destaca la importancia de los factores genéticos que regulan el componente inmune durante la respuesta inflamatoria. Con base en tales conocimientos, esta revisión se centra en genes de citocinas importantes en el curso clínico de la sepsis, en la información sobre sus variantes genéticas en la población con sepsis y en su impacto sobre la función del gen. Estos factores son de importancia crítica y un mejor conocimiento acerca de ellos podría ayudar a evaluar el riesgo de desarrollar sepsis y a definir su asociación con la evolución clínica de este síndrome. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Iatreia is the property of Universidad de Antioquia and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=lth&AN=85102234 |
| RecordInfo | BibRecord: BibEntity: Languages: – Code: spa Text: Spanish PhysicalDescription: Pagination: PageCount: 10 StartPage: 67 Subjects: – SubjectFull: SEPSIS Type: general – SubjectFull: ANTI-inflammatory agents Type: general – SubjectFull: CYTOKINES Type: general – SubjectFull: GENETIC polymorphisms Type: general – SubjectFull: GENE expression Type: general Titles: – TitleFull: Variaciones alélicas en los genes de citocinas proinflamatorias y antiinflamatorias, y su asociación con la susceptibilidad y el curso clínico de la sepsis. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Montoya Ruiz, Carolina – PersonEntity: Name: NameFull: Rugeles López, María Teresa – PersonEntity: Name: NameFull: Jaimes Barragán, Fabián Alberto – PersonEntity: Name: NameFull: Velilla Hernández, Paula Andrea IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Text: ene-mar2013 Type: published Y: 2013 Identifiers: – Type: issn-print Value: 01210793 Numbering: – Type: volume Value: 26 – Type: issue Value: 1 Titles: – TitleFull: Iatreia Type: main |
| ResultId | 1 |
