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Sensibilidad y especificidad de la prueba cutánea por punción con extractos alergénicos estandarizados de Dermatophagoides pteronyssinus en adultos.

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Title: Sensibilidad y especificidad de la prueba cutánea por punción con extractos alergénicos estandarizados de Dermatophagoides pteronyssinus en adultos.
Alternate Title: Sensitivity and Specificity of Skin Prick Test with standardized allergen extracts of Dermatophagoides pteronyssinus in adults.
Authors: Lázaro Castro, Raúl1 rcastro@biocen.cu, Rodríguez, Janet2, Ronquillo, Mercedes2, Álvarez, Mirta2, González, Mayda3, Rodríguez, José2, Ivonne Navarro, Bárbara1, Mateo, Mayte1, Oliva, Yunia1, Enríquez, Irene2, Labrada, Alexis1
Source: Revista VacciMonitor (Vacunología y Temas Afines). may-ago2013, Vol. 22 Issue 2, p24-29. 6p. 2 Charts, 2 Graphs.
Subjects: ALLERGY diagnosis, SKIN tests, ALLERGENS, DERMATOPHAGOIDES pteronyssinus, IMMUNOGLOBULIN E, ETIOLOGY of diseases, SENSITIVITY analysis
Abstract (English): Skin Prick Test (SPT) using standardized mite allergen extracts is a sensitive and reliable diagnostic tool. IgE sensitization to domestic mites has been identified worldwide as a major cause of respiratory allergic diseases. In Cuba, the most relevant species are: Dermatophagoides pteronyssinus (Dp), D. siboney and Blomia tropicalis. The aim of this work was to determine the diagnostic efficacy of SPT, using an standardized allergen extract of Dp, of national production (VALERGEN-DP, BIOCEN) and two other well known foreign commercial products (A: ALK, Netherlands and B: Stallergenes, France). An analytical study involving 50 patients with allergic antecedents to domestic dust and positive serum IgE and 50 with identical antecedents, but negative serum IgE was conducted. Replicate punctures were performed in both arms of patients using a concentration of 20 000 BU/mL. SPT with VALERGEN-DP produced a wheal mean of 43.5 mm2, superior value statistically significant with respect to A product (p = 0.002). Diagnostic coincidence among the three products was 98-99 %. SPT with VALERGEN-DP showed 98% of specificity and 82% of sensibility and significant differences were not detected (p>0.05) between products for these parameters. Diagnostic efficacy of SPT using a validated allergenic extract of national production (VALERGEN-DP) was similar to SPT with the other standard extracts, what supports its use for the diagnosis from the sensitization to Dermatophagoides pteronyssinus in patients with allergic symptoms to domestic dust. [ABSTRACT FROM AUTHOR]
Abstract (Spanish): La prueba cutánea por punción (PCP), que utiliza extractos alergénicos estandarizados de ácaros, es una herramienta diagnóstica sensible y confiable. La sensibilización IgE a los ácaros domésticos es una de las principales causas de enfermedades alérgicas respiratorias. En Cuba las especies de ácaros más relevantes son: Dermatophagoides pteronyssinus (Dp), D. siboney y Blomia tropicalis. El objetivo de este trabajo fue determinar la eficacia diagnóstica de la PCP, utilizando un extracto alergénico estandarizado de Dp de producción nacional (VALERGEN-DP, BIOCEN) y otros dos estándares comerciales foráneos (A: ALK, Holanda y B: Stallergenes, Francia). Se realizó un estudio analítico, conducido en 50 pacientes con antecedentes de alergia al polvo doméstico y IgE sérica positiva al Dp y 50 con iguales antecedentes, pero con IgE sérica negativa. Se realizaron réplicas de las punturas en ambos brazos, con una concentración de 20 000 UB/mL. En esta prueba con VALERGEN-DP el promedio del habón fue de 43,5 mm2, un valor superior estadísticamente significativo con respecto el producto A (p=0,002). La coincidencia diagnóstica entre los tres productos fue de 98-99%. La PCP con VALERGEN-DP mostró un 98% de especificidad y 82% de sensibilidad. No fueron detectadas diferencias significativas (p>0,05) entre los productos para estos parámetros. La eficacia diagnóstica de la PCP con el VALERGEN-DP fue similar a la que se obtuvo utilizando dos extractos estándar, lo que justifica su utilización para el diagnóstico de la sensibilización a Dp en pacientes con síntomas de alergia frente al polvo doméstico. [ABSTRACT FROM AUTHOR]
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Database: MedicLatina
Description
Abstract:Skin Prick Test (SPT) using standardized mite allergen extracts is a sensitive and reliable diagnostic tool. IgE sensitization to domestic mites has been identified worldwide as a major cause of respiratory allergic diseases. In Cuba, the most relevant species are: Dermatophagoides pteronyssinus (Dp), D. siboney and Blomia tropicalis. The aim of this work was to determine the diagnostic efficacy of SPT, using an standardized allergen extract of Dp, of national production (VALERGEN-DP, BIOCEN) and two other well known foreign commercial products (A: ALK, Netherlands and B: Stallergenes, France). An analytical study involving 50 patients with allergic antecedents to domestic dust and positive serum IgE and 50 with identical antecedents, but negative serum IgE was conducted. Replicate punctures were performed in both arms of patients using a concentration of 20 000 BU/mL. SPT with VALERGEN-DP produced a wheal mean of 43.5 mm2, superior value statistically significant with respect to A product (p = 0.002). Diagnostic coincidence among the three products was 98-99 %. SPT with VALERGEN-DP showed 98% of specificity and 82% of sensibility and significant differences were not detected (p>0.05) between products for these parameters. Diagnostic efficacy of SPT using a validated allergenic extract of national production (VALERGEN-DP) was similar to SPT with the other standard extracts, what supports its use for the diagnosis from the sensitization to Dermatophagoides pteronyssinus in patients with allergic symptoms to domestic dust. [ABSTRACT FROM AUTHOR]
ISSN:1025028X