Relación entre la hemólisis intravascular microangiopática y la disfunción renal en pacientes con preeclampsia.
Saved in:
| Title: | Relación entre la hemólisis intravascular microangiopática y la disfunción renal en pacientes con preeclampsia. |
|---|---|
| Authors: | Duarte-Mote, Jesús1 hgnsjduarte@yahoo.com.mx, Jiménez A. J., Miguel2, Lee-Eng C., Víctor3, Romero F., Socorro4, Espinosa L., Rogelio F.5, Jiménez A., Mari Carmen6, Sánchez R., Graciela7, Verduzco P., Julio8, Calvo C., Jesús8 |
| Source: | Medicina Interna de México. jul/ago2013, Vol. 29 Issue 4, p351-355. 5p. |
| Subjects: | THROMBOTIC thrombocytopenic purpura, HEMOLYSIS & hemolysins, KIDNEY diseases, DISEASE complications, ENDOTHELIAL cells, PREECLAMPSIA, BLOOD platelet disorders |
| Abstract (English): | Background: Preeclampsia is today one of the most important causes of maternal morbidity and mortality. Renal dysfunction is one of the main complications in such patients and is a marker of severity of the process. The microangiopathic intravascular hemolysis is a manifestation of severe endothelial dysfunction and is related to perfusorious systemic problems in patients with preeclampsia. Microangiopathic intravascular hemolysis may be a marker associated with renal dysfunction. Objective: To determine if thrombotic intravascular hemolysis is a marker of bad evolution in patients with preeclampsia in the immediate postpartum. Material and method: An observational study included patients with preeclampsia admitted to the Obstetric Unit. Patients were classified into two groups: with renal dysfunction (serum creatinine levels ≥ 0.9 mg/dL) or normal renal function. Microangiopathic intravascular hemolysis was analyzed if patients presented positive peripheral blood smear, hemoglobinuria, elevated levels of lactic acid dehydrogenase and thrombocytopenia. Results: 81 patients with preeclampsia were included, at entering to Obstetric Unit 23 (28.3%) had renal dysfunction and 58 (71.7%) had normal renal function. At the 24 hours after partum 35 patients (43.2%) had renal dysfunction and 46 (56.8%) had normal renal function. Microangiopathic intravascular hemolysis was presented in six patients at entering and after 24 hours (7.4%). Al entering 17.3% and 3.4% of patients with renal dysfunction and normal renal function, respectively, presented microangiopathic intravascular hemolysis, OR 5.89 (95 CI 0.9-34.7) p = 0.031. At the 24 hours after partum 11.4% had renal dysfunction and 4.3% had normal renal function, OR 2.83 (95 CI 0.4-16.4) p = 0.2. In regard to peripheral blood smear, to the admission of the patients, 60.8% had renal dysfunction and 36.2% had normal renal function, OR 2.74 (CI 1.01-7.40) p = 0.0043. To 24 hours, 60% had renal dysfunction and 30.4% had normal renal function, OR 3.42 (95 CI 1.36-8.62) p = 0.008. Conclusion: Microangiopathic intravascular hemolysis has an inconsistent behavior in relation to renal dysfunction, in contrast to the presence of blurred cells on the peripheral blood smear. [ABSTRACT FROM AUTHOR] |
| Abstract (Spanish): | Antecedentes: en la actualidad la preeclampsia es una de las causas de morbilidad y mortalidad materna más importantes. La disfunción renal es una de las principales complicaciones en las pacientes con preeclampsia y un marcador de gravedad del proceso. La hemólisis intravascular microangiopática es una manifestación de disfunción endotelial grave y se relaciona con los problemas de perfusión sistémicos en las pacientes con preeclampsia. La hemólisis intravascular microangiopática puede ser un marcador de disfunción renal. Objetivo: determinar si la hemólisis intravascular trombótica microangiopática es un marcador de mala evolución en el posparto inmediato en las pacientes con preeclampsia. Material y método: estudio observacional que incluyó a pacientes con preeclampsia ingresadas a la Unidad de Tococirugía. Las pacientes se dividieron en dos grupos: con disfunción renal (concentraciones séricas de creatinina ≥ 0.9 mg/dL) o con función renal normal. Se analizó la hemólisis intravascular microangiopática si las pacientes tenían frotis de sangre periférica positivo, hemoglobinuria, elevación de las concentraciones de deshidrogenasa láctica y trombocitopenia. Resultados: se incluyeron 81 pacientes con preeclampsia; al ingreso a la Unidad de Tococirugía, 23 (28.3%) tenían disfunción renal y 58 (71.7%) función renal normal. A las 24 horas 35 pacientes (43.2%) tenían disfunción renal y 46 (56.8%) función renal normal. La hemólisis intravascular microangiopática afectó a seis pacientes (7.4%) al ingreso y a las 24 horas del parto. Al ingreso 17.3 y 3.4% de las pacientes con disfunción renal y función renal normal, respectivamente, tuvieron hemólisis intravascular microangiopática (IC 95 0.9-34.7) p = 0.031. A las 24 horas, 11.4% tenía disfunción renal y 4.3% función renal normal, razón de momios de 2.83 (IC 95 0.4-16.4) p = 0.2. Con respecto al frotis de sangre periférica, al ingreso de las pacientes 60.8% tenía disfunción renal y 36.2% función renal normal, razón de momios de 2.74 (IC 95 1.01-7.40) p = 0.0043. A las 24 horas, 60% tenía disfunción renal y 30.4% función renal normal, razón de momios de 3.42 (IC 95 1.36-8.62) p = 0.008. Conclusiones: la hemólisis intravascular microangiopática se comporta de manera inconsistente en relación con la disfunción renal, a diferencia de la existencia de esquizocitos en el frotis de sangre periférica. [ABSTRACT FROM AUTHOR] |
| Copyright of Medicina Interna de México is the property of Colegio de Medicina Interna de Mexico and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | MedicLatina |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
|---|---|
| Header | DbId: lth DbLabel: MedicLatina An: 91534573 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: Relación entre la hemólisis intravascular microangiopática y la disfunción renal en pacientes con preeclampsia. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Duarte-Mote%2C+Jesús%22">Duarte-Mote, Jesús</searchLink><relatesTo>1</relatesTo><i> hgnsjduarte@yahoo.com.mx</i><br /><searchLink fieldCode="AR" term="%22Jiménez+A%2E+J%2E%2C+Miguel%22">Jiménez A. J., Miguel</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Lee-Eng+C%2E%2C+Víctor%22">Lee-Eng C., Víctor</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Romero+F%2E%2C+Socorro%22">Romero F., Socorro</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Espinosa+L%2E%2C+Rogelio+F%2E%22">Espinosa L., Rogelio F.</searchLink><relatesTo>5</relatesTo><br /><searchLink fieldCode="AR" term="%22Jiménez+A%2E%2C+Mari+Carmen%22">Jiménez A., Mari Carmen</searchLink><relatesTo>6</relatesTo><br /><searchLink fieldCode="AR" term="%22Sánchez+R%2E%2C+Graciela%22">Sánchez R., Graciela</searchLink><relatesTo>7</relatesTo><br /><searchLink fieldCode="AR" term="%22Verduzco+P%2E%2C+Julio%22">Verduzco P., Julio</searchLink><relatesTo>8</relatesTo><br /><searchLink fieldCode="AR" term="%22Calvo+C%2E%2C+Jesús%22">Calvo C., Jesús</searchLink><relatesTo>8</relatesTo> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Medicina+Interna+de+México%22">Medicina Interna de México</searchLink>. jul/ago2013, Vol. 29 Issue 4, p351-355. 5p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22THROMBOTIC+thrombocytopenic+purpura%22">THROMBOTIC thrombocytopenic purpura</searchLink><br /><searchLink fieldCode="DE" term="%22HEMOLYSIS+%26+hemolysins%22">HEMOLYSIS & hemolysins</searchLink><br /><searchLink fieldCode="DE" term="%22KIDNEY+diseases%22">KIDNEY diseases</searchLink><br /><searchLink fieldCode="DE" term="%22DISEASE+complications%22">DISEASE complications</searchLink><br /><searchLink fieldCode="DE" term="%22ENDOTHELIAL+cells%22">ENDOTHELIAL cells</searchLink><br /><searchLink fieldCode="DE" term="%22PREECLAMPSIA%22">PREECLAMPSIA</searchLink><br /><searchLink fieldCode="DE" term="%22BLOOD+platelet+disorders%22">BLOOD platelet disorders</searchLink> – Name: Abstract Label: Abstract (English) Group: Ab Data: Background: Preeclampsia is today one of the most important causes of maternal morbidity and mortality. Renal dysfunction is one of the main complications in such patients and is a marker of severity of the process. The microangiopathic intravascular hemolysis is a manifestation of severe endothelial dysfunction and is related to perfusorious systemic problems in patients with preeclampsia. Microangiopathic intravascular hemolysis may be a marker associated with renal dysfunction. Objective: To determine if thrombotic intravascular hemolysis is a marker of bad evolution in patients with preeclampsia in the immediate postpartum. Material and method: An observational study included patients with preeclampsia admitted to the Obstetric Unit. Patients were classified into two groups: with renal dysfunction (serum creatinine levels ≥ 0.9 mg/dL) or normal renal function. Microangiopathic intravascular hemolysis was analyzed if patients presented positive peripheral blood smear, hemoglobinuria, elevated levels of lactic acid dehydrogenase and thrombocytopenia. Results: 81 patients with preeclampsia were included, at entering to Obstetric Unit 23 (28.3%) had renal dysfunction and 58 (71.7%) had normal renal function. At the 24 hours after partum 35 patients (43.2%) had renal dysfunction and 46 (56.8%) had normal renal function. Microangiopathic intravascular hemolysis was presented in six patients at entering and after 24 hours (7.4%). Al entering 17.3% and 3.4% of patients with renal dysfunction and normal renal function, respectively, presented microangiopathic intravascular hemolysis, OR 5.89 (95 CI 0.9-34.7) p = 0.031. At the 24 hours after partum 11.4% had renal dysfunction and 4.3% had normal renal function, OR 2.83 (95 CI 0.4-16.4) p = 0.2. In regard to peripheral blood smear, to the admission of the patients, 60.8% had renal dysfunction and 36.2% had normal renal function, OR 2.74 (CI 1.01-7.40) p = 0.0043. To 24 hours, 60% had renal dysfunction and 30.4% had normal renal function, OR 3.42 (95 CI 1.36-8.62) p = 0.008. Conclusion: Microangiopathic intravascular hemolysis has an inconsistent behavior in relation to renal dysfunction, in contrast to the presence of blurred cells on the peripheral blood smear. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Abstract (Spanish) Group: Ab Data: Antecedentes: en la actualidad la preeclampsia es una de las causas de morbilidad y mortalidad materna más importantes. La disfunción renal es una de las principales complicaciones en las pacientes con preeclampsia y un marcador de gravedad del proceso. La hemólisis intravascular microangiopática es una manifestación de disfunción endotelial grave y se relaciona con los problemas de perfusión sistémicos en las pacientes con preeclampsia. La hemólisis intravascular microangiopática puede ser un marcador de disfunción renal. Objetivo: determinar si la hemólisis intravascular trombótica microangiopática es un marcador de mala evolución en el posparto inmediato en las pacientes con preeclampsia. Material y método: estudio observacional que incluyó a pacientes con preeclampsia ingresadas a la Unidad de Tococirugía. Las pacientes se dividieron en dos grupos: con disfunción renal (concentraciones séricas de creatinina ≥ 0.9 mg/dL) o con función renal normal. Se analizó la hemólisis intravascular microangiopática si las pacientes tenían frotis de sangre periférica positivo, hemoglobinuria, elevación de las concentraciones de deshidrogenasa láctica y trombocitopenia. Resultados: se incluyeron 81 pacientes con preeclampsia; al ingreso a la Unidad de Tococirugía, 23 (28.3%) tenían disfunción renal y 58 (71.7%) función renal normal. A las 24 horas 35 pacientes (43.2%) tenían disfunción renal y 46 (56.8%) función renal normal. La hemólisis intravascular microangiopática afectó a seis pacientes (7.4%) al ingreso y a las 24 horas del parto. Al ingreso 17.3 y 3.4% de las pacientes con disfunción renal y función renal normal, respectivamente, tuvieron hemólisis intravascular microangiopática (IC 95 0.9-34.7) p = 0.031. A las 24 horas, 11.4% tenía disfunción renal y 4.3% función renal normal, razón de momios de 2.83 (IC 95 0.4-16.4) p = 0.2. Con respecto al frotis de sangre periférica, al ingreso de las pacientes 60.8% tenía disfunción renal y 36.2% función renal normal, razón de momios de 2.74 (IC 95 1.01-7.40) p = 0.0043. A las 24 horas, 60% tenía disfunción renal y 30.4% función renal normal, razón de momios de 3.42 (IC 95 1.36-8.62) p = 0.008. Conclusiones: la hemólisis intravascular microangiopática se comporta de manera inconsistente en relación con la disfunción renal, a diferencia de la existencia de esquizocitos en el frotis de sangre periférica. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Medicina Interna de México is the property of Colegio de Medicina Interna de Mexico and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=lth&AN=91534573 |
| RecordInfo | BibRecord: BibEntity: Languages: – Code: spa Text: Spanish PhysicalDescription: Pagination: PageCount: 5 StartPage: 351 Subjects: – SubjectFull: THROMBOTIC thrombocytopenic purpura Type: general – SubjectFull: HEMOLYSIS & hemolysins Type: general – SubjectFull: KIDNEY diseases Type: general – SubjectFull: DISEASE complications Type: general – SubjectFull: ENDOTHELIAL cells Type: general – SubjectFull: PREECLAMPSIA Type: general – SubjectFull: BLOOD platelet disorders Type: general Titles: – TitleFull: Relación entre la hemólisis intravascular microangiopática y la disfunción renal en pacientes con preeclampsia. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Duarte-Mote, Jesús – PersonEntity: Name: NameFull: Jiménez A. J., Miguel – PersonEntity: Name: NameFull: Lee-Eng C., Víctor – PersonEntity: Name: NameFull: Romero F., Socorro – PersonEntity: Name: NameFull: Espinosa L., Rogelio F. – PersonEntity: Name: NameFull: Jiménez A., Mari Carmen – PersonEntity: Name: NameFull: Sánchez R., Graciela – PersonEntity: Name: NameFull: Verduzco P., Julio – PersonEntity: Name: NameFull: Calvo C., Jesús IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 07 Text: jul/ago2013 Type: published Y: 2013 Identifiers: – Type: issn-print Value: 01864866 Numbering: – Type: volume Value: 29 – Type: issue Value: 4 Titles: – TitleFull: Medicina Interna de México Type: main |
| ResultId | 1 |
