Bibliographic Details
| Title: |
Current therapies in rheumatoid arthritis: A Latin American perspective. |
| Alternate Title: |
Las terapias actuales en la artritis reumatoide: una perspectiva latinoamericana. |
| Authors: |
Burgos-Vargas, Rubén1 r.burgos.vargas@gmail.com, Catoggio, Luis Jose2,3, Galarza-Maldonado, Claudio4, Ostojich, Kasmir5, Cardiel, Mario H.6 |
| Source: |
Reumatología Clínica. mar/abr2013, Vol. 9 Issue 2, p106-112. 7p. |
| Subjects: |
RHEUMATOID arthritis treatment, LATIN Americans, SYNOVIAL membranes, TENDONS, RHEUMATOLOGISTS, TUMOR necrosis factors, INTERLEUKIN-6 receptors, DISEASES |
| Abstract (English): |
Rheumatoid arthritis (RA) is a systemic inflammatory disease affecting the synovium of joints, tendons, and some extra-articular sites. RA prevalence in Latin America ranges from 0.4 to 1.6%. Early treatment of RA translates into a substantial reduction in the cost to society. In light of this, early disease clinics are being established in some countries. Barriers to RA management, such as delay in referral to rheumatologists and limited access to therapy, have been identified. Evidence-based treatment guidelines have been adapted by countries according to their own situations. The need for keeping accurate records of biologics prescribed has been addressed by biologic registries, thereby contributing toward a better understanding of rheumatic diseases and their treatment. Current biologics include the tumor necrosis factor (TNF)-α inhibitors (etanercept, infliximab, and adalimumab), B-cell depletion agent (rituximab), interleukin-6 receptor blocker (tocilizumab), and T-cell co-stimulatory blocker (abatacept). Future therapies include kinase inhibitors (tofacitinib and fostamatinib), alternative TNF-α inhibitors (golimumab and certolizumab), and biosimilars. [ABSTRACT FROM AUTHOR] |
| Abstract (Spanish): |
La artritis reumatoide (AR) es una enfermedad sistémica e inflamatoria que afecta la membrana sinovial de las articulaciones, los tendones y algunos sitios extra-articulares. La prevalencia de la AR en Latinoamérica se encuentra entre 0.4-1.6%. El tratamiento precoz de la enfermedad se traduce en una reducción del costo para la sociedad. En vista de esto, se han establecido clínicas de AR temprana en varios países de la región. Se han identificado barreras para el tratamiento de la AR como lo son el retraso en la referencia al reumatólogo y limitaciones en el acceso al tratamiento. Varios países han desarrollado y adaptado guías para el tratamiento basadas en la evidencia y en sus propias realidades. La necesidad de tener registros detallados de las prescripciones de biológicos ha sido abordada con registros de biológicos lo que llevará a un mejor entendimiento de las enfermedades reumáticas y su tratamiento. Los biológicos disponibles en la actualidad son los inhibidores del factor de necrosis tumoral (TNF)-α (etanercept, infliximab y adalimumab), un agente depletor de células B (rituximab), un bloqueador del receptor de interleucina-6 (tocilizumab) y un bloqueador de la co-estimulación de células T (abatacept). En el futuro se incluirán los inhibidores de cinasas (tofacitinib y fostamatinib) e inhibidores del TNF-α alternativos (golimumab y certolizumab) y biosimilares. [ABSTRACT FROM AUTHOR] |
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| Database: |
MedicLatina |
