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Of Bugs and Joints: The Relationship Between Infection and Joints.

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Title: Of Bugs and Joints: The Relationship Between Infection and Joints.
Alternate Title: Microbios y articulaciones: la relación entre infección y articulaciones.
Authors: Espinoza, Luis R.1 lespin1@lsuhsc.edu, García-Valladares, Ignacio1
Source: Reumatología Clínica. jul/ago2013, Vol. 9 Issue 4, p229-238. 10p.
Subjects: INFECTION, INFECTIOUS arthritis, MORTALITY, THERAPEUTICS, CHLAMYDIA trachomatis, CHIKUNGUNYA virus, IMMUNE reconstitution inflammatory syndrome, DIAGNOSIS
Abstract (English): The association between microbes and joints has existed since antiquity, and remains complex. Diagnosis is often difficult to determine despite highly suspicious clinical characteristics for the presence of an underlying infection. Over the several past decades, considerable advances have occurred in diagnostic methodologies and therapy. However, the morbidity and mortality of septic arthritis remain high. Great advances have occurred in the diagnosis, pathogenesis, and therapeutic management of reactive arthritis, and there is evidence that when the responsible microorganism is Chlamydia trachomatis, complete remission and cure are possible. Emergent infections, especially viral, have been recognized, that is, HIV, hepatitis C, and most recently Chikungunya virus, and in the case of HIV associated articular manifestations, the introduction of HAART has resulted in a decrease in the incidence and development of newer complications such as the immune reconstitution syndrome. The infectious etiology of rheumatoid arthritis is being strongly considered once again, and the exciting association with periodontal disease is at the forefront of intense research. The gut microbiota is also being investigated and new and most interesting data are being gathered of the potential role of commensal gut organisms and the pathogenesis of rheumatoid arthritis. [ABSTRACT FROM AUTHOR]
Abstract (Spanish): La asociación entre las infecciones y la inflamación articular ha existido desde tiempos remotos y continúa siendo compleja. El diagnóstico es frecuentemente difícil de determinar, a pesar de la presencia de hallazgos clínicos que sugieren un proceso infeccioso. En las últimas décadas, han ocurrido considerables avances en metodología tanto diagnóstica como terapéutica. Sin embargo, la morbilidad y la mortalidad de la artritis séptica siguen siendo altas. Grandes adelantos han ocurrido en el diagnóstico, patogénesis y manejo terapéutico de la artritis reactiva, y hay evidencia de que cuando el patógeno responsable es Chlamydia trachomatis puede haber remisión completa y la cura es posible. Algunas infecciones emergentes, especialmente virales han sido reconocidas, por ejemplo, virus de inmunodeficiencia humana (VIH), de la hepatitis C, y más recientemente, el virus de Chickengunya. En los casos de VIH, la asociación de manifestaciones articulares y la introducción de la terapia antrirretroviral altamente activa (TARAA) han resultado en una disminución en la incidencia y el desarrollo de nuevas complicaciones, tales como el síndrome de reconstitución inmunológica. La infección como causa de la artritis reumatoide (AR) está siendo considerada nuevamente y la asociación con enfermedad periodontal ha vuelto a ser tema de gran interés e investigación. La microbiota intestinal también está siendo investigada y nuevos e interesantes datos han surgido, como es el papel potencial de los organismos comensales en el intestino como agentes causales en la AR. [ABSTRACT FROM AUTHOR]
Copyright of Reumatología Clínica is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: MedicLatina
FullText Text:
  Availability: 0
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PubType: Academic Journal
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  Data: Of Bugs and Joints: The Relationship Between Infection and Joints.
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  Data: Microbios y articulaciones: la relación entre infección y articulaciones.
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  Data: <searchLink fieldCode="AR" term="%22Espinoza%2C+Luis+R%2E%22">Espinoza, Luis R.</searchLink><relatesTo>1</relatesTo><i> lespin1@lsuhsc.edu</i><br /><searchLink fieldCode="AR" term="%22García-Valladares%2C+Ignacio%22">García-Valladares, Ignacio</searchLink><relatesTo>1</relatesTo>
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  Data: <searchLink fieldCode="JN" term="%22Reumatología+Clínica%22">Reumatología Clínica</searchLink>. jul/ago2013, Vol. 9 Issue 4, p229-238. 10p.
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  Data: <searchLink fieldCode="DE" term="%22INFECTION%22">INFECTION</searchLink><br /><searchLink fieldCode="DE" term="%22INFECTIOUS+arthritis%22">INFECTIOUS arthritis</searchLink><br /><searchLink fieldCode="DE" term="%22MORTALITY%22">MORTALITY</searchLink><br /><searchLink fieldCode="DE" term="%22THERAPEUTICS%22">THERAPEUTICS</searchLink><br /><searchLink fieldCode="DE" term="%22CHLAMYDIA+trachomatis%22">CHLAMYDIA trachomatis</searchLink><br /><searchLink fieldCode="DE" term="%22CHIKUNGUNYA+virus%22">CHIKUNGUNYA virus</searchLink><br /><searchLink fieldCode="DE" term="%22IMMUNE+reconstitution+inflammatory+syndrome%22">IMMUNE reconstitution inflammatory syndrome</searchLink><br /><searchLink fieldCode="DE" term="%22DIAGNOSIS%22">DIAGNOSIS</searchLink>
– Name: Abstract
  Label: Abstract (English)
  Group: Ab
  Data: The association between microbes and joints has existed since antiquity, and remains complex. Diagnosis is often difficult to determine despite highly suspicious clinical characteristics for the presence of an underlying infection. Over the several past decades, considerable advances have occurred in diagnostic methodologies and therapy. However, the morbidity and mortality of septic arthritis remain high. Great advances have occurred in the diagnosis, pathogenesis, and therapeutic management of reactive arthritis, and there is evidence that when the responsible microorganism is Chlamydia trachomatis, complete remission and cure are possible. Emergent infections, especially viral, have been recognized, that is, HIV, hepatitis C, and most recently Chikungunya virus, and in the case of HIV associated articular manifestations, the introduction of HAART has resulted in a decrease in the incidence and development of newer complications such as the immune reconstitution syndrome. The infectious etiology of rheumatoid arthritis is being strongly considered once again, and the exciting association with periodontal disease is at the forefront of intense research. The gut microbiota is also being investigated and new and most interesting data are being gathered of the potential role of commensal gut organisms and the pathogenesis of rheumatoid arthritis. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label: Abstract (Spanish)
  Group: Ab
  Data: La asociación entre las infecciones y la inflamación articular ha existido desde tiempos remotos y continúa siendo compleja. El diagnóstico es frecuentemente difícil de determinar, a pesar de la presencia de hallazgos clínicos que sugieren un proceso infeccioso. En las últimas décadas, han ocurrido considerables avances en metodología tanto diagnóstica como terapéutica. Sin embargo, la morbilidad y la mortalidad de la artritis séptica siguen siendo altas. Grandes adelantos han ocurrido en el diagnóstico, patogénesis y manejo terapéutico de la artritis reactiva, y hay evidencia de que cuando el patógeno responsable es Chlamydia trachomatis puede haber remisión completa y la cura es posible. Algunas infecciones emergentes, especialmente virales han sido reconocidas, por ejemplo, virus de inmunodeficiencia humana (VIH), de la hepatitis C, y más recientemente, el virus de Chickengunya. En los casos de VIH, la asociación de manifestaciones articulares y la introducción de la terapia antrirretroviral altamente activa (TARAA) han resultado en una disminución en la incidencia y el desarrollo de nuevas complicaciones, tales como el síndrome de reconstitución inmunológica. La infección como causa de la artritis reumatoide (AR) está siendo considerada nuevamente y la asociación con enfermedad periodontal ha vuelto a ser tema de gran interés e investigación. La microbiota intestinal también está siendo investigada y nuevos e interesantes datos han surgido, como es el papel potencial de los organismos comensales en el intestino como agentes causales en la AR. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of Reumatología Clínica is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=lth&AN=96001257
RecordInfo BibRecord:
  BibEntity:
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 10
        StartPage: 229
    Subjects:
      – SubjectFull: INFECTION
        Type: general
      – SubjectFull: INFECTIOUS arthritis
        Type: general
      – SubjectFull: MORTALITY
        Type: general
      – SubjectFull: THERAPEUTICS
        Type: general
      – SubjectFull: CHLAMYDIA trachomatis
        Type: general
      – SubjectFull: CHIKUNGUNYA virus
        Type: general
      – SubjectFull: IMMUNE reconstitution inflammatory syndrome
        Type: general
      – SubjectFull: DIAGNOSIS
        Type: general
    Titles:
      – TitleFull: Of Bugs and Joints: The Relationship Between Infection and Joints.
        Type: main
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          Name:
            NameFull: Espinoza, Luis R.
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            NameFull: García-Valladares, Ignacio
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          Dates:
            – D: 01
              M: 07
              Text: jul/ago2013
              Type: published
              Y: 2013
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              Value: 9
            – Type: issue
              Value: 4
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            – TitleFull: Reumatología Clínica
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