Demostración y caracterización in silico del fenómeno de resonancia estocástica en sinapsis nociceptivas del tipo NMDA del asta dorsal medular.
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| Title: | Demostración y caracterización in silico del fenómeno de resonancia estocástica en sinapsis nociceptivas del tipo NMDA del asta dorsal medular. |
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| Alternate Title: | In silico demonstration and characterization of the stochastic resonance phenomena in a NMDA type nociceptive synapsis of the spinal dorsal horn. |
| Authors: | Henríquez, Yohani, Eblen-Zajjur, Antonio |
| Source: | Archivos de Neurociencias. oct-dic2013, Vol. 18 Issue 4, p182-189. 8p. 3 Charts, 7 Graphs. |
| Subjects: | NEURAL physiology, SPINAL cord physiology, NOCICEPTORS, CELLULAR signal transduction, ELECTRIC stimulation, NEUROPHYSIOLOGY, DESCRIPTIVE statistics, PHYSIOLOGY |
| Abstract (English): | Aim: nociceptive primary afferents establish synapses in the spinal dorsal horn (SDH) expressing mainly glutamatergic strongly excitatory NMDA type ionotropic channels. SDH postsynaptic neurons generate discharges inmersed in different noise levels which is classically considerated a signal transmission adverse factor. Material and method: in the present study, the effects of different noise levels (NL) was evaluated on a experimentally described model of NMDA type synapse between nociceptive SDH neurons. Pre and postsinaptic number of spikes, interspike intervals (ISI) and the post/presynaptic spike quotient were studied with a neuronal network simulator (Neurosim: Network v 1.2a.). The NL was progresssively increased (0 to ±5mV) in both spontaneous activity and evoked by a electrical stimulus (pulse ±29nA). Res ults: It was found a proportional increase of synaptic efficiency with NL with a logaríthmic function: Post/Pre Spike Quotient = 3,38+0,26NL- 0,029NL2 (r=+0,67; P<0,05), the ISI for presynaptic: ISI = 14,33- 1,33NL+0,06NL2 but also postsynaptic: ISI= 6,66- 0,85NL+0,06NL2 showed a proportional decrease with NL (r=-0,72 and r=-0,79; respectively P<0,05). Conclusion: these results strongly suggest, for the first time, that the NL increases the synaptic efficiency in the model of NMDA type synapse between nociceptive SDH neurons, this phenomenon of interest in nociception, named stochastic resonance, was described first in others places of the central nervous system. [ABSTRACT FROM AUTHOR] |
| Abstract (Spanish): | Objetivo: los aferentes primarios nociceptivos establecen sinapsis en el asta dorsal medular (ADM) expresando predominantemente canales glutamatérgicos ionotrópicos del tipo NMDA intensamente excitatorios. Las neuronas posinápticas del ADM generan descargas inmersas en diferentes niveles de ruido, el cual, clásicamente es considerado como factor que afecta la señal transmitida. Material y métodos: en el presente estudio se evaluó el efecto de diferentes niveles de ruido en sinapsis NMDA de neuronas nociceptivas del ADM sobre el número de espigas e intervalo interespiga (IIE), mediante el simulador de redes neuronales neurosim: network v 1. 2 a. usando un modelo sináptico NMDA ajustado a las descripciones experimentales del asta dorsal medular se incrementó el nivel de ruido (NR) progresivamente de 0 a ±5mV en actividad espontánea como estimulada con un pulso de ±29nA. Se evaluó el número de descargas pre, posinápticas, cociente y los IIE para cada NR pre o posináptico. Resultados: existe un incremento de la eficiencia sináptica proporcional al NR siguiendo una función logarítmica: cociente de descargas pos/pre = 3,38+0,26NR-0,029NR2 (r=+0,67; P‹0,05). Los IIE tanto pre: IIE = 14,33-1,33NR+0,06NR2 como posinápticos: IIE= 6,66-0,85NR+0,06NR2 mostraron una reducción proporcional al NR (r=-0,72 y r=-0,79; respectivamente P‹0,05). Conclusiones: estos resultados sugieren que el incremento del NR en el modelo de sinapsis tipo NMDA del ADM incrementa la eficiencia sináptica este fenómeno, de interés en nocicepción, se denomina resonancia estocástica, ha sido descrito en otras partes del sistema nervioso central. [ABSTRACT FROM AUTHOR] |
| Copyright of Archivos de Neurociencias is the property of Instituto Nacional de Neurologia y Neurocirugia, Departamento de Publicaciones Cientificas and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
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| Items | – Name: Title Label: Title Group: Ti Data: Demostración y caracterización in silico del fenómeno de resonancia estocástica en sinapsis nociceptivas del tipo NMDA del asta dorsal medular. – Name: TitleAlt Label: Alternate Title Group: TiAlt Data: In silico demonstration and characterization of the stochastic resonance phenomena in a NMDA type nociceptive synapsis of the spinal dorsal horn. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Henríquez%2C+Yohani%22">Henríquez, Yohani</searchLink><br /><searchLink fieldCode="AR" term="%22Eblen-Zajjur%2C+Antonio%22">Eblen-Zajjur, Antonio</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Archivos+de+Neurociencias%22">Archivos de Neurociencias</searchLink>. oct-dic2013, Vol. 18 Issue 4, p182-189. 8p. 3 Charts, 7 Graphs. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22NEURAL+physiology%22">NEURAL physiology</searchLink><br /><searchLink fieldCode="DE" term="%22SPINAL+cord+physiology%22">SPINAL cord physiology</searchLink><br /><searchLink fieldCode="DE" term="%22NOCICEPTORS%22">NOCICEPTORS</searchLink><br /><searchLink fieldCode="DE" term="%22CELLULAR+signal+transduction%22">CELLULAR signal transduction</searchLink><br /><searchLink fieldCode="DE" term="%22ELECTRIC+stimulation%22">ELECTRIC stimulation</searchLink><br /><searchLink fieldCode="DE" term="%22NEUROPHYSIOLOGY%22">NEUROPHYSIOLOGY</searchLink><br /><searchLink fieldCode="DE" term="%22DESCRIPTIVE+statistics%22">DESCRIPTIVE statistics</searchLink><br /><searchLink fieldCode="DE" term="%22PHYSIOLOGY%22">PHYSIOLOGY</searchLink> – Name: Abstract Label: Abstract (English) Group: Ab Data: Aim: nociceptive primary afferents establish synapses in the spinal dorsal horn (SDH) expressing mainly glutamatergic strongly excitatory NMDA type ionotropic channels. SDH postsynaptic neurons generate discharges inmersed in different noise levels which is classically considerated a signal transmission adverse factor. Material and method: in the present study, the effects of different noise levels (NL) was evaluated on a experimentally described model of NMDA type synapse between nociceptive SDH neurons. Pre and postsinaptic number of spikes, interspike intervals (ISI) and the post/presynaptic spike quotient were studied with a neuronal network simulator (Neurosim: Network v 1.2a.). The NL was progresssively increased (0 to ±5mV) in both spontaneous activity and evoked by a electrical stimulus (pulse ±29nA). Res ults: It was found a proportional increase of synaptic efficiency with NL with a logaríthmic function: Post/Pre Spike Quotient = 3,38+0,26NL- 0,029NL2 (r=+0,67; P<0,05), the ISI for presynaptic: ISI = 14,33- 1,33NL+0,06NL2 but also postsynaptic: ISI= 6,66- 0,85NL+0,06NL2 showed a proportional decrease with NL (r=-0,72 and r=-0,79; respectively P<0,05). Conclusion: these results strongly suggest, for the first time, that the NL increases the synaptic efficiency in the model of NMDA type synapse between nociceptive SDH neurons, this phenomenon of interest in nociception, named stochastic resonance, was described first in others places of the central nervous system. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Abstract (Spanish) Group: Ab Data: Objetivo: los aferentes primarios nociceptivos establecen sinapsis en el asta dorsal medular (ADM) expresando predominantemente canales glutamatérgicos ionotrópicos del tipo NMDA intensamente excitatorios. Las neuronas posinápticas del ADM generan descargas inmersas en diferentes niveles de ruido, el cual, clásicamente es considerado como factor que afecta la señal transmitida. Material y métodos: en el presente estudio se evaluó el efecto de diferentes niveles de ruido en sinapsis NMDA de neuronas nociceptivas del ADM sobre el número de espigas e intervalo interespiga (IIE), mediante el simulador de redes neuronales neurosim: network v 1. 2 a. usando un modelo sináptico NMDA ajustado a las descripciones experimentales del asta dorsal medular se incrementó el nivel de ruido (NR) progresivamente de 0 a ±5mV en actividad espontánea como estimulada con un pulso de ±29nA. Se evaluó el número de descargas pre, posinápticas, cociente y los IIE para cada NR pre o posináptico. Resultados: existe un incremento de la eficiencia sináptica proporcional al NR siguiendo una función logarítmica: cociente de descargas pos/pre = 3,38+0,26NR-0,029NR2 (r=+0,67; P‹0,05). Los IIE tanto pre: IIE = 14,33-1,33NR+0,06NR2 como posinápticos: IIE= 6,66-0,85NR+0,06NR2 mostraron una reducción proporcional al NR (r=-0,72 y r=-0,79; respectivamente P‹0,05). Conclusiones: estos resultados sugieren que el incremento del NR en el modelo de sinapsis tipo NMDA del ADM incrementa la eficiencia sináptica este fenómeno, de interés en nocicepción, se denomina resonancia estocástica, ha sido descrito en otras partes del sistema nervioso central. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Archivos de Neurociencias is the property of Instituto Nacional de Neurologia y Neurocirugia, Departamento de Publicaciones Cientificas and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Languages: – Code: spa Text: Spanish PhysicalDescription: Pagination: PageCount: 8 StartPage: 182 Subjects: – SubjectFull: NEURAL physiology Type: general – SubjectFull: SPINAL cord physiology Type: general – SubjectFull: NOCICEPTORS Type: general – SubjectFull: CELLULAR signal transduction Type: general – SubjectFull: ELECTRIC stimulation Type: general – SubjectFull: NEUROPHYSIOLOGY Type: general – SubjectFull: DESCRIPTIVE statistics Type: general – SubjectFull: PHYSIOLOGY Type: general Titles: – TitleFull: Demostración y caracterización in silico del fenómeno de resonancia estocástica en sinapsis nociceptivas del tipo NMDA del asta dorsal medular. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Henríquez, Yohani – PersonEntity: Name: NameFull: Eblen-Zajjur, Antonio IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 10 Text: oct-dic2013 Type: published Y: 2013 Identifiers: – Type: issn-print Value: 10285938 Numbering: – Type: volume Value: 18 – Type: issue Value: 4 Titles: – TitleFull: Archivos de Neurociencias Type: main |
| ResultId | 1 |
