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Piperazine-based CCR5 antagonists as HIV-1 inhibitors. II. Discovery of 1-[(2,4-dimethyl-3-pyridinyl)carbonyl]-4- methyl-4-[3(S)-methyl-4-[1(S)-[4-(trifluoromethyl)phenyl]ethyl]-1-piperazinyl]- piperidine N1-oxide (Sch-350634), an orally bioavailable, potent CCR5 antagonist.

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Title: Piperazine-based CCR5 antagonists as HIV-1 inhibitors. II. Discovery of 1-[(2,4-dimethyl-3-pyridinyl)carbonyl]-4- methyl-4-[3(S)-methyl-4-[1(S)-[4-(trifluoromethyl)phenyl]ethyl]-1-piperazinyl]- piperidine N1-oxide (Sch-350634), an orally bioavailable, potent CCR5 antagonist.
Authors: Tagat JR; Departments of Chemical Research, Drug Metabolism & Pharmacokinetics, and Antiviral Therapy, Schering-Plough Research Institute, K-15-2B-2800, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, USA. jayaram.tagat@spcorp.com, Steensma RW, McCombie SW, Nazareno DV, Lin SI, Neustadt BR, Cox K, Xu S, Wojcik L, Murray MG, Vantuno N, Baroudy BM, Strizki JM
Source: Journal of medicinal chemistry [J Med Chem] 2001 Oct 11; Vol. 44 (21), pp. 3343-6.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print Cited Medium: Print ISSN: 0022-2623 (Print) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Piperazine-based CCR5 antagonists as HIV-1 inhibitors. II. Discovery of 1-[(2,4-dimethyl-3-pyridinyl)carbonyl]-4- methyl-4-[3(S)-methyl-4-[1(S)-[4-(trifluoromethyl)phenyl]ethyl]-1-piperazinyl]- piperidine N1-oxide (Sch-350634), an orally bioavailable, potent CCR5 antagonist.
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  Data: <searchLink fieldCode="AU" term="%22Tagat+JR%22">Tagat JR</searchLink>; Departments of Chemical Research, Drug Metabolism & Pharmacokinetics, and Antiviral Therapy, Schering-Plough Research Institute, K-15-2B-2800, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, USA. jayaram.tagat@spcorp.com<br /><searchLink fieldCode="AU" term="%22Steensma+RW%22">Steensma RW</searchLink><br /><searchLink fieldCode="AU" term="%22McCombie+SW%22">McCombie SW</searchLink><br /><searchLink fieldCode="AU" term="%22Nazareno+DV%22">Nazareno DV</searchLink><br /><searchLink fieldCode="AU" term="%22Lin+SI%22">Lin SI</searchLink><br /><searchLink fieldCode="AU" term="%22Neustadt+BR%22">Neustadt BR</searchLink><br /><searchLink fieldCode="AU" term="%22Cox+K%22">Cox K</searchLink><br /><searchLink fieldCode="AU" term="%22Xu+S%22">Xu S</searchLink><br /><searchLink fieldCode="AU" term="%22Wojcik+L%22">Wojcik L</searchLink><br /><searchLink fieldCode="AU" term="%22Murray+MG%22">Murray MG</searchLink><br /><searchLink fieldCode="AU" term="%22Vantuno+N%22">Vantuno N</searchLink><br /><searchLink fieldCode="AU" term="%22Baroudy+BM%22">Baroudy BM</searchLink><br /><searchLink fieldCode="AU" term="%22Strizki+JM%22">Strizki JM</searchLink>
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9716531 <i>Publication Model: </i>Print <i>Cited Medium: </i>Print <i>ISSN: </i>0022-2623 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200222623%22">00222623 </searchLink><i>NLM ISO Abbreviation: </i>J Med Chem <i>Subsets: </i>MEDLINE
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        Value: 10.1021/jm0155401
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        Text: English
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        StartPage: 3343
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      – TitleFull: Piperazine-based CCR5 antagonists as HIV-1 inhibitors. II. Discovery of 1-[(2,4-dimethyl-3-pyridinyl)carbonyl]-4- methyl-4-[3(S)-methyl-4-[1(S)-[4-(trifluoromethyl)phenyl]ethyl]-1-piperazinyl]- piperidine N1-oxide (Sch-350634), an orally bioavailable, potent CCR5 antagonist.
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              Text: 2001 Oct 11
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              Y: 2001
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              Value: 44
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