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Synthesis and biological evaluation of thiol-based inhibitors of glutamate carboxypeptidase II: discovery of an orally active GCP II inhibitor.

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Title: Synthesis and biological evaluation of thiol-based inhibitors of glutamate carboxypeptidase II: discovery of an orally active GCP II inhibitor.
Authors: Majer P; Guilford Pharmaceuticals Inc., 6611 Tributary Street, Baltimore, Maryland 21224, USA., Jackson PF, Delahanty G, Grella BS, Ko YS, Li W, Liu Q, Maclin KM, Poláková J, Shaffer KA, Stoermer D, Vitharana D, Wang EY, Zakrzewski A, Rojas C, Slusher BS, Wozniak KM, Burak E, Limsakun T, Tsukamoto T
Source: Journal of medicinal chemistry [J Med Chem] 2003 May 08; Vol. 46 (10), pp. 1989-96.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print Cited Medium: Print ISSN: 0022-2623 (Print) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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DbLabel: MEDLINE Ultimate
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AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: Synthesis and biological evaluation of thiol-based inhibitors of glutamate carboxypeptidase II: discovery of an orally active GCP II inhibitor.
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  Data: <searchLink fieldCode="AU" term="%22Majer+P%22">Majer P</searchLink>; Guilford Pharmaceuticals Inc., 6611 Tributary Street, Baltimore, Maryland 21224, USA.<br /><searchLink fieldCode="AU" term="%22Jackson+PF%22">Jackson PF</searchLink><br /><searchLink fieldCode="AU" term="%22Delahanty+G%22">Delahanty G</searchLink><br /><searchLink fieldCode="AU" term="%22Grella+BS%22">Grella BS</searchLink><br /><searchLink fieldCode="AU" term="%22Ko+YS%22">Ko YS</searchLink><br /><searchLink fieldCode="AU" term="%22Li+W%22">Li W</searchLink><br /><searchLink fieldCode="AU" term="%22Liu+Q%22">Liu Q</searchLink><br /><searchLink fieldCode="AU" term="%22Maclin+KM%22">Maclin KM</searchLink><br /><searchLink fieldCode="AU" term="%22Poláková+J%22">Poláková J</searchLink><br /><searchLink fieldCode="AU" term="%22Shaffer+KA%22">Shaffer KA</searchLink><br /><searchLink fieldCode="AU" term="%22Stoermer+D%22">Stoermer D</searchLink><br /><searchLink fieldCode="AU" term="%22Vitharana+D%22">Vitharana D</searchLink><br /><searchLink fieldCode="AU" term="%22Wang+EY%22">Wang EY</searchLink><br /><searchLink fieldCode="AU" term="%22Zakrzewski+A%22">Zakrzewski A</searchLink><br /><searchLink fieldCode="AU" term="%22Rojas+C%22">Rojas C</searchLink><br /><searchLink fieldCode="AU" term="%22Slusher+BS%22">Slusher BS</searchLink><br /><searchLink fieldCode="AU" term="%22Wozniak+KM%22">Wozniak KM</searchLink><br /><searchLink fieldCode="AU" term="%22Burak+E%22">Burak E</searchLink><br /><searchLink fieldCode="AU" term="%22Limsakun+T%22">Limsakun T</searchLink><br /><searchLink fieldCode="AU" term="%22Tsukamoto+T%22">Tsukamoto T</searchLink>
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  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2003 May 08; Vol. 46 (10), pp. 1989-96.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9716531 <i>Publication Model: </i>Print <i>Cited Medium: </i>Print <i>ISSN: </i>0022-2623 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200222623%22">00222623 </searchLink><i>NLM ISO Abbreviation: </i>J Med Chem <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=12723961
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      – Type: doi
        Value: 10.1021/jm020515w
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      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 1989
    Titles:
      – TitleFull: Synthesis and biological evaluation of thiol-based inhibitors of glutamate carboxypeptidase II: discovery of an orally active GCP II inhibitor.
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            NameFull: Majer P
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          Dates:
            – D: 08
              M: 05
              Text: 2003 May 08
              Type: published
              Y: 2003
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              Value: 0022-2623
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              Value: 46
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              Value: 10
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            – TitleFull: Journal of medicinal chemistry
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