View in EDS

Piperazine-based CCR5 antagonists as HIV-1 inhibitors. IV. Discovery of 1-[(4,6-dimethyl-5-pyrimidinyl)carbonyl]- 4-[4-[2-methoxy-1(R)-4-(trifluoromethyl)phenyl]ethyl-3(S)-methyl-1-piperazinyl]- 4-methylpiperidine (Sch-417690/Sch-D), a potent, highly selective, and orally bioavailable CCR5 antagonist.

Saved in:
Bibliographic Details
Title: Piperazine-based CCR5 antagonists as HIV-1 inhibitors. IV. Discovery of 1-[(4,6-dimethyl-5-pyrimidinyl)carbonyl]- 4-[4-[2-methoxy-1(R)-4-(trifluoromethyl)phenyl]ethyl-3(S)-methyl-1-piperazinyl]- 4-methylpiperidine (Sch-417690/Sch-D), a potent, highly selective, and orally bioavailable CCR5 antagonist.
Authors: Tagat JR; Schering-Plough Research Institute, K-15-2B-2800, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, USA. jayaram.tagat@spcorp.com, McCombie SW, Nazareno D, Labroli MA, Xiao Y, Steensma RW, Strizki JM, Baroudy BM, Cox K, Lachowicz J, Varty G, Watkins R
Source: Journal of medicinal chemistry [J Med Chem] 2004 May 06; Vol. 47 (10), pp. 2405-8.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print Cited Medium: Print ISSN: 0022-2623 (Print) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 15115380
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Piperazine-based CCR5 antagonists as HIV-1 inhibitors. IV. Discovery of 1-[(4,6-dimethyl-5-pyrimidinyl)carbonyl]- 4-[4-[2-methoxy-1(R)-4-(trifluoromethyl)phenyl]ethyl-3(S)-methyl-1-piperazinyl]- 4-methylpiperidine (Sch-417690/Sch-D), a potent, highly selective, and orally bioavailable CCR5 antagonist.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Tagat+JR%22">Tagat JR</searchLink>; Schering-Plough Research Institute, K-15-2B-2800, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, USA. jayaram.tagat@spcorp.com<br /><searchLink fieldCode="AU" term="%22McCombie+SW%22">McCombie SW</searchLink><br /><searchLink fieldCode="AU" term="%22Nazareno+D%22">Nazareno D</searchLink><br /><searchLink fieldCode="AU" term="%22Labroli+MA%22">Labroli MA</searchLink><br /><searchLink fieldCode="AU" term="%22Xiao+Y%22">Xiao Y</searchLink><br /><searchLink fieldCode="AU" term="%22Steensma+RW%22">Steensma RW</searchLink><br /><searchLink fieldCode="AU" term="%22Strizki+JM%22">Strizki JM</searchLink><br /><searchLink fieldCode="AU" term="%22Baroudy+BM%22">Baroudy BM</searchLink><br /><searchLink fieldCode="AU" term="%22Cox+K%22">Cox K</searchLink><br /><searchLink fieldCode="AU" term="%22Lachowicz+J%22">Lachowicz J</searchLink><br /><searchLink fieldCode="AU" term="%22Varty+G%22">Varty G</searchLink><br /><searchLink fieldCode="AU" term="%22Watkins+R%22">Watkins R</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2004 May 06; Vol. 47 (10), pp. 2405-8.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9716531 <i>Publication Model: </i>Print <i>Cited Medium: </i>Print <i>ISSN: </i>0022-2623 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200222623%22">00222623 </searchLink><i>NLM ISO Abbreviation: </i>J Med Chem <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=15115380
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1021/jm0304515
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 2405
    Titles:
      – TitleFull: Piperazine-based CCR5 antagonists as HIV-1 inhibitors. IV. Discovery of 1-[(4,6-dimethyl-5-pyrimidinyl)carbonyl]- 4-[4-[2-methoxy-1(R)-4-(trifluoromethyl)phenyl]ethyl-3(S)-methyl-1-piperazinyl]- 4-methylpiperidine (Sch-417690/Sch-D), a potent, highly selective, and orally bioavailable CCR5 antagonist.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Tagat JR
      – PersonEntity:
          Name:
            NameFull: McCombie SW
      – PersonEntity:
          Name:
            NameFull: Nazareno D
      – PersonEntity:
          Name:
            NameFull: Labroli MA
      – PersonEntity:
          Name:
            NameFull: Xiao Y
      – PersonEntity:
          Name:
            NameFull: Steensma RW
      – PersonEntity:
          Name:
            NameFull: Strizki JM
      – PersonEntity:
          Name:
            NameFull: Baroudy BM
      – PersonEntity:
          Name:
            NameFull: Cox K
      – PersonEntity:
          Name:
            NameFull: Lachowicz J
      – PersonEntity:
          Name:
            NameFull: Varty G
      – PersonEntity:
          Name:
            NameFull: Watkins R
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 06
              M: 05
              Text: 2004 May 06
              Type: published
              Y: 2004
          Identifiers:
            – Type: issn-print
              Value: 0022-2623
          Numbering:
            – Type: volume
              Value: 47
            – Type: issue
              Value: 10
          Titles:
            – TitleFull: Journal of medicinal chemistry
              Type: main
ResultId 1