Challenges in the conduct of large simple trials of important generic questions in resource-poor settings: the CREATE and ECLA trial program evaluating GIK (glucose, insulin and potassium) and low-molecular-weight heparin in acute myocardial infarction. - Yusuf S; Mehta SR; Díaz R; Paolasso E; Pais P; Xavier D; Xie C; Ahmed RJ; Khazmi K; Zhu J; Liu L (American heart journal, 2004)