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Intrinsic efficacy of antipsychotics at human D2, D3, and D4 dopamine receptors: identification of the clozapine metabolite N-desmethylclozapine as a D2/D3 partial agonist.

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Title: Intrinsic efficacy of antipsychotics at human D2, D3, and D4 dopamine receptors: identification of the clozapine metabolite N-desmethylclozapine as a D2/D3 partial agonist.
Authors: Burstein ES; ACADIA Pharmaceuticals, 3911 Sorrento Valley Blvd., San Diego, CA 92121, USA. eburstein@acadia-pharm.com, Ma J, Wong S, Gao Y, Pham E, Knapp AE, Nash NR, Olsson R, Davis RE, Hacksell U, Weiner DM, Brann MR
Source: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2005 Dec; Vol. 315 (3), pp. 1278-87. Date of Electronic Publication: 2005 Aug 31.
Publication Type: Comparative Study; Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0376362 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0022-3565 (Print) Linking ISSN: 00223565 NLM ISO Abbreviation: J Pharmacol Exp Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Intrinsic efficacy of antipsychotics at human D2, D3, and D4 dopamine receptors: identification of the clozapine metabolite N-desmethylclozapine as a D2/D3 partial agonist.
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  Data: <searchLink fieldCode="AU" term="%22Burstein+ES%22">Burstein ES</searchLink>; ACADIA Pharmaceuticals, 3911 Sorrento Valley Blvd., San Diego, CA 92121, USA. eburstein@acadia-pharm.com<br /><searchLink fieldCode="AU" term="%22Ma+J%22">Ma J</searchLink><br /><searchLink fieldCode="AU" term="%22Wong+S%22">Wong S</searchLink><br /><searchLink fieldCode="AU" term="%22Gao+Y%22">Gao Y</searchLink><br /><searchLink fieldCode="AU" term="%22Pham+E%22">Pham E</searchLink><br /><searchLink fieldCode="AU" term="%22Knapp+AE%22">Knapp AE</searchLink><br /><searchLink fieldCode="AU" term="%22Nash+NR%22">Nash NR</searchLink><br /><searchLink fieldCode="AU" term="%22Olsson+R%22">Olsson R</searchLink><br /><searchLink fieldCode="AU" term="%22Davis+RE%22">Davis RE</searchLink><br /><searchLink fieldCode="AU" term="%22Hacksell+U%22">Hacksell U</searchLink><br /><searchLink fieldCode="AU" term="%22Weiner+DM%22">Weiner DM</searchLink><br /><searchLink fieldCode="AU" term="%22Brann+MR%22">Brann MR</searchLink>
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  Data: <searchLink fieldCode="JN" term="%220376362%22">The Journal of pharmacology and experimental therapeutics</searchLink> [J Pharmacol Exp Ther] 2005 Dec; Vol. 315 (3), pp. 1278-87. <i>Date of Electronic Publication: </i>2005 Aug 31.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>0376362 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Print <i>ISSN: </i>0022-3565 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200223565%22">00223565 </searchLink><i>NLM ISO Abbreviation: </i>J Pharmacol Exp Ther <i>Subsets: </i>MEDLINE
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        Value: 10.1124/jpet.105.092155
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      – TitleFull: Intrinsic efficacy of antipsychotics at human D2, D3, and D4 dopamine receptors: identification of the clozapine metabolite N-desmethylclozapine as a D2/D3 partial agonist.
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              Text: 2005 Dec
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