Two classes of p38alpha MAP kinase inhibitors having a common diphenylether core but exhibiting divergent binding modes. - Michelotti EL; Moffett KK; Nguyen D; Kelly MJ; Shetty R; Chai X; Northrop K; Namboodiri V; Campbell B; Flynn GA; Fujimoto T; Hollinger FP; et al. (Bioorganic & medicinal chemistry letters, 2005)