Nicotinamide protected first-phase insulin response (FPIR) and prevented clinical disease in first-degree relatives of type-1 diabetics. - Olmos PR; Hodgson MI; Maiz A; Manrique M; De Valdés MD; Foncea R; Acosta AM; Emmerich MV; Velasco S; Muñiz OP; Oyarzún CA; Claro JC; et al. (Diabetes research and clinical practice, 2006)