Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination. - Di Marcotullio L; Ferretti E; Greco A; De Smaele E; Po A; Sico MA; Alimandi M; Giannini G; Maroder M; Screpanti I; Gulino A (Nature cell biology, 2006)