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Matched molecular pairs as a guide in the optimization of pharmaceutical properties; a study of aqueous solubility, plasma protein binding and oral exposure.

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Title: Matched molecular pairs as a guide in the optimization of pharmaceutical properties; a study of aqueous solubility, plasma protein binding and oral exposure.
Authors: Leach AG; AstraZeneca Pharmaceuticals, Mereside, Alderley Park, Macclesfield SK10 4TG, UK. andrew.leach@astrazeneca.com, Jones HD, Cosgrove DA, Kenny PW, Ruston L, MacFaul P, Wood JM, Colclough N, Law B
Source: Journal of medicinal chemistry [J Med Chem] 2006 Nov 16; Vol. 49 (23), pp. 6672-82.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print Cited Medium: Print ISSN: 0022-2623 (Print) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Leach+AG%22">Leach AG</searchLink>; AstraZeneca Pharmaceuticals, Mereside, Alderley Park, Macclesfield SK10 4TG, UK. andrew.leach@astrazeneca.com<br /><searchLink fieldCode="AU" term="%22Jones+HD%22">Jones HD</searchLink><br /><searchLink fieldCode="AU" term="%22Cosgrove+DA%22">Cosgrove DA</searchLink><br /><searchLink fieldCode="AU" term="%22Kenny+PW%22">Kenny PW</searchLink><br /><searchLink fieldCode="AU" term="%22Ruston+L%22">Ruston L</searchLink><br /><searchLink fieldCode="AU" term="%22MacFaul+P%22">MacFaul P</searchLink><br /><searchLink fieldCode="AU" term="%22Wood+JM%22">Wood JM</searchLink><br /><searchLink fieldCode="AU" term="%22Colclough+N%22">Colclough N</searchLink><br /><searchLink fieldCode="AU" term="%22Law+B%22">Law B</searchLink>
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  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2006 Nov 16; Vol. 49 (23), pp. 6672-82.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9716531 <i>Publication Model: </i>Print <i>Cited Medium: </i>Print <i>ISSN: </i>0022-2623 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200222623%22">00222623 </searchLink><i>NLM ISO Abbreviation: </i>J Med Chem <i>Subsets: </i>MEDLINE
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        Value: 10.1021/jm0605233
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        Text: English
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              Text: 2006 Nov 16
              Type: published
              Y: 2006
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            – TitleFull: Journal of medicinal chemistry
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