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Next-generation spirobenzazepines: identification of RWJ-676070 as a balanced vasopressin V1a/V2 receptor antagonist for human clinical studies.

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Title: Next-generation spirobenzazepines: identification of RWJ-676070 as a balanced vasopressin V1a/V2 receptor antagonist for human clinical studies.
Authors: Xiang MA; Research and Early Development, Johnson & Johnson Pharmaceutical Research & Development, 8 Clarke Drive, Cranbury, NJ 08512, USA., Rybczynski PJ, Patel M, Chen RH, McComsey DF, Zhang HC, Gunnet JW, Look R, Wang Y, Minor LK, Zhong HM, Villani FJ, Demarest KT, Damiano BP, Maryanoff BE
Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2007 Dec 01; Vol. 17 (23), pp. 6623-8. Date of Electronic Publication: 2007 Sep 19.
Publication Type: Comparative Study; Journal Article
Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE
Database: MEDLINE Ultimate
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Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 17942308
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: Next-generation spirobenzazepines: identification of RWJ-676070 as a balanced vasopressin V1a/V2 receptor antagonist for human clinical studies.
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  Data: <searchLink fieldCode="AU" term="%22Xiang+MA%22">Xiang MA</searchLink>; Research and Early Development, Johnson & Johnson Pharmaceutical Research & Development, 8 Clarke Drive, Cranbury, NJ 08512, USA.<br /><searchLink fieldCode="AU" term="%22Rybczynski+PJ%22">Rybczynski PJ</searchLink><br /><searchLink fieldCode="AU" term="%22Patel+M%22">Patel M</searchLink><br /><searchLink fieldCode="AU" term="%22Chen+RH%22">Chen RH</searchLink><br /><searchLink fieldCode="AU" term="%22McComsey+DF%22">McComsey DF</searchLink><br /><searchLink fieldCode="AU" term="%22Zhang+HC%22">Zhang HC</searchLink><br /><searchLink fieldCode="AU" term="%22Gunnet+JW%22">Gunnet JW</searchLink><br /><searchLink fieldCode="AU" term="%22Look+R%22">Look R</searchLink><br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink><br /><searchLink fieldCode="AU" term="%22Minor+LK%22">Minor LK</searchLink><br /><searchLink fieldCode="AU" term="%22Zhong+HM%22">Zhong HM</searchLink><br /><searchLink fieldCode="AU" term="%22Villani+FJ%22">Villani FJ</searchLink><br /><searchLink fieldCode="AU" term="%22Demarest+KT%22">Demarest KT</searchLink><br /><searchLink fieldCode="AU" term="%22Damiano+BP%22">Damiano BP</searchLink><br /><searchLink fieldCode="AU" term="%22Maryanoff+BE%22">Maryanoff BE</searchLink>
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  Data: <searchLink fieldCode="JN" term="%229107377%22">Bioorganic & medicinal chemistry letters</searchLink> [Bioorg Med Chem Lett] 2007 Dec 01; Vol. 17 (23), pp. 6623-8. <i>Date of Electronic Publication: </i>2007 Sep 19.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science+Ltd%22">Elsevier Science Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9107377 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1464-3405 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%220960894X%22">0960894X </searchLink><i>NLM ISO Abbreviation: </i>Bioorg Med Chem Lett <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.bmcl.2007.09.059
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        Text: English
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        StartPage: 6623
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      – TitleFull: Next-generation spirobenzazepines: identification of RWJ-676070 as a balanced vasopressin V1a/V2 receptor antagonist for human clinical studies.
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              Text: 2007 Dec 01
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