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Discovery of potent cholecystokinin-2 receptor antagonists: elucidation of key pharmacophore elements by X-ray crystallographic and NMR conformational analysis.

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Title: Discovery of potent cholecystokinin-2 receptor antagonists: elucidation of key pharmacophore elements by X-ray crystallographic and NMR conformational analysis.
Authors: Rosen MD; Johnson & Johnson Pharmaceutical Research and Development, L.L.C., Drug Discover, 3210 Merryfield Row, San Diego, CA 92121, USA. mrosen1@prdus.jnj.com, Hack MD, Allison BD, Phuong VK, Woods CR, Morton MF, Prendergast CE, Barrett TD, Schubert C, Li L, Wu X, Wu J, Freedman JM, Shankley NP, Rabinowitz MH
Source: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2008 Apr 01; Vol. 16 (7), pp. 3917-25. Date of Electronic Publication: 2008 Feb 05.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3391 (Electronic) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 18289861
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: Discovery of potent cholecystokinin-2 receptor antagonists: elucidation of key pharmacophore elements by X-ray crystallographic and NMR conformational analysis.
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  Data: <searchLink fieldCode="AU" term="%22Rosen+MD%22">Rosen MD</searchLink>; Johnson & Johnson Pharmaceutical Research and Development, L.L.C., Drug Discover, 3210 Merryfield Row, San Diego, CA 92121, USA. mrosen1@prdus.jnj.com<br /><searchLink fieldCode="AU" term="%22Hack+MD%22">Hack MD</searchLink><br /><searchLink fieldCode="AU" term="%22Allison+BD%22">Allison BD</searchLink><br /><searchLink fieldCode="AU" term="%22Phuong+VK%22">Phuong VK</searchLink><br /><searchLink fieldCode="AU" term="%22Woods+CR%22">Woods CR</searchLink><br /><searchLink fieldCode="AU" term="%22Morton+MF%22">Morton MF</searchLink><br /><searchLink fieldCode="AU" term="%22Prendergast+CE%22">Prendergast CE</searchLink><br /><searchLink fieldCode="AU" term="%22Barrett+TD%22">Barrett TD</searchLink><br /><searchLink fieldCode="AU" term="%22Schubert+C%22">Schubert C</searchLink><br /><searchLink fieldCode="AU" term="%22Li+L%22">Li L</searchLink><br /><searchLink fieldCode="AU" term="%22Wu+X%22">Wu X</searchLink><br /><searchLink fieldCode="AU" term="%22Wu+J%22">Wu J</searchLink><br /><searchLink fieldCode="AU" term="%22Freedman+JM%22">Freedman JM</searchLink><br /><searchLink fieldCode="AU" term="%22Shankley+NP%22">Shankley NP</searchLink><br /><searchLink fieldCode="AU" term="%22Rabinowitz+MH%22">Rabinowitz MH</searchLink>
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  Data: <searchLink fieldCode="JN" term="%229413298%22">Bioorganic & medicinal chemistry</searchLink> [Bioorg Med Chem] 2008 Apr 01; Vol. 16 (7), pp. 3917-25. <i>Date of Electronic Publication: </i>2008 Feb 05.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science%22">Elsevier Science </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9413298 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1464-3391 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2209680896%22">09680896 </searchLink><i>NLM ISO Abbreviation: </i>Bioorg Med Chem <i>Subsets: </i>MEDLINE
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      – Type: doi
        Value: 10.1016/j.bmc.2008.01.059
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      – Code: eng
        Text: English
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        StartPage: 3917
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      – TitleFull: Discovery of potent cholecystokinin-2 receptor antagonists: elucidation of key pharmacophore elements by X-ray crystallographic and NMR conformational analysis.
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            – D: 01
              M: 04
              Text: 2008 Apr 01
              Type: published
              Y: 2008
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              Value: 16
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            – TitleFull: Bioorganic & medicinal chemistry
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