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Discovery of novel hydroxy-thiazoles as HIF-alpha prolyl hydroxylase inhibitors: SAR, synthesis, and modeling evaluation.

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Title: Discovery of novel hydroxy-thiazoles as HIF-alpha prolyl hydroxylase inhibitors: SAR, synthesis, and modeling evaluation.
Authors: Tegley CM; Chemistry Research and Discovery, Amgen, Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA. ctegley@amgen.com, Viswanadhan VN, Biswas K, Frohn MJ, Peterkin TA, Chang C, Bürli RW, Dao JH, Veith H, Rogers N, Yoder SC, Biddlecome G, Tagari P, Allen JR, Hungate RW
Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2008 Jul 15; Vol. 18 (14), pp. 3925-8. Date of Electronic Publication: 2008 Jun 13.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE
Database: MEDLINE Ultimate
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Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 18579373
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
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  Data: Discovery of novel hydroxy-thiazoles as HIF-alpha prolyl hydroxylase inhibitors: SAR, synthesis, and modeling evaluation.
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  Data: <searchLink fieldCode="AU" term="%22Tegley+CM%22">Tegley CM</searchLink>; Chemistry Research and Discovery, Amgen, Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA. ctegley@amgen.com<br /><searchLink fieldCode="AU" term="%22Viswanadhan+VN%22">Viswanadhan VN</searchLink><br /><searchLink fieldCode="AU" term="%22Biswas+K%22">Biswas K</searchLink><br /><searchLink fieldCode="AU" term="%22Frohn+MJ%22">Frohn MJ</searchLink><br /><searchLink fieldCode="AU" term="%22Peterkin+TA%22">Peterkin TA</searchLink><br /><searchLink fieldCode="AU" term="%22Chang+C%22">Chang C</searchLink><br /><searchLink fieldCode="AU" term="%22Bürli+RW%22">Bürli RW</searchLink><br /><searchLink fieldCode="AU" term="%22Dao+JH%22">Dao JH</searchLink><br /><searchLink fieldCode="AU" term="%22Veith+H%22">Veith H</searchLink><br /><searchLink fieldCode="AU" term="%22Rogers+N%22">Rogers N</searchLink><br /><searchLink fieldCode="AU" term="%22Yoder+SC%22">Yoder SC</searchLink><br /><searchLink fieldCode="AU" term="%22Biddlecome+G%22">Biddlecome G</searchLink><br /><searchLink fieldCode="AU" term="%22Tagari+P%22">Tagari P</searchLink><br /><searchLink fieldCode="AU" term="%22Allen+JR%22">Allen JR</searchLink><br /><searchLink fieldCode="AU" term="%22Hungate+RW%22">Hungate RW</searchLink>
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  Data: <searchLink fieldCode="JN" term="%229107377%22">Bioorganic & medicinal chemistry letters</searchLink> [Bioorg Med Chem Lett] 2008 Jul 15; Vol. 18 (14), pp. 3925-8. <i>Date of Electronic Publication: </i>2008 Jun 13.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science+Ltd%22">Elsevier Science Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9107377 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1464-3405 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%220960894X%22">0960894X </searchLink><i>NLM ISO Abbreviation: </i>Bioorg Med Chem Lett <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.bmcl.2008.06.031
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        Text: English
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        StartPage: 3925
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              Text: 2008 Jul 15
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