Discovery of sodium R-(+)-4-{2-[5-(2-fluoro-3-methoxyphenyl)-3-(2-fluoro-6-[trifluoromethyl]benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenylethylamino}butyrate (elagolix), a potent and orally available nonpeptide antagonist of the human gonadotropin-releasing hormone receptor. - Chen C; Wu D; Guo Z; Xie Q; Reinhart GJ; Madan A; Wen J; Chen T; Huang CQ; Chen M; Chen Y; Tucci FC; et al. (Journal of medicinal chemistry, 2008)