Identification of amidoheteroaryls as potent inhibitors of mutant (V600E) B-Raf kinase with in vivo activity.
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| Title: | Identification of amidoheteroaryls as potent inhibitors of mutant (V600E) B-Raf kinase with in vivo activity. |
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| Authors: | Lyne PD; Cancer Research, AstraZeneca R&D Boston, 35 Gatehouse Drive, Waltham, MA 02451, USA. paul.lyne@astrazeneca.com, Aquila B, Cook DJ, Dakin LA, Ezhuthachan J, Ioannidis S, Pontz T, Su M, Ye Q, Zheng X, Block MH, Cowen S, Deegan TL, Lee JW, Scott DA, Custeau D, Drew L, Poondru S, Shen M, Wu A |
| Source: | Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2009 Feb 01; Vol. 19 (3), pp. 1026-9. Date of Electronic Publication: 2008 Oct 15. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 19097792 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Identification of amidoheteroaryls as potent inhibitors of mutant (V600E) B-Raf kinase with in vivo activity. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Lyne+PD%22">Lyne PD</searchLink>; Cancer Research, AstraZeneca R&D Boston, 35 Gatehouse Drive, Waltham, MA 02451, USA. paul.lyne@astrazeneca.com<br /><searchLink fieldCode="AU" term="%22Aquila+B%22">Aquila B</searchLink><br /><searchLink fieldCode="AU" term="%22Cook+DJ%22">Cook DJ</searchLink><br /><searchLink fieldCode="AU" term="%22Dakin+LA%22">Dakin LA</searchLink><br /><searchLink fieldCode="AU" term="%22Ezhuthachan+J%22">Ezhuthachan J</searchLink><br /><searchLink fieldCode="AU" term="%22Ioannidis+S%22">Ioannidis S</searchLink><br /><searchLink fieldCode="AU" term="%22Pontz+T%22">Pontz T</searchLink><br /><searchLink fieldCode="AU" term="%22Su+M%22">Su M</searchLink><br /><searchLink fieldCode="AU" term="%22Ye+Q%22">Ye Q</searchLink><br /><searchLink fieldCode="AU" term="%22Zheng+X%22">Zheng X</searchLink><br /><searchLink fieldCode="AU" term="%22Block+MH%22">Block MH</searchLink><br /><searchLink fieldCode="AU" term="%22Cowen+S%22">Cowen S</searchLink><br /><searchLink fieldCode="AU" term="%22Deegan+TL%22">Deegan TL</searchLink><br /><searchLink fieldCode="AU" term="%22Lee+JW%22">Lee JW</searchLink><br /><searchLink fieldCode="AU" term="%22Scott+DA%22">Scott DA</searchLink><br /><searchLink fieldCode="AU" term="%22Custeau+D%22">Custeau D</searchLink><br /><searchLink fieldCode="AU" term="%22Drew+L%22">Drew L</searchLink><br /><searchLink fieldCode="AU" term="%22Poondru+S%22">Poondru S</searchLink><br /><searchLink fieldCode="AU" term="%22Shen+M%22">Shen M</searchLink><br /><searchLink fieldCode="AU" term="%22Wu+A%22">Wu A</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%229107377%22">Bioorganic & medicinal chemistry letters</searchLink> [Bioorg Med Chem Lett] 2009 Feb 01; Vol. 19 (3), pp. 1026-9. <i>Date of Electronic Publication: </i>2008 Oct 15. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science+Ltd%22">Elsevier Science Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9107377 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1464-3405 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%220960894X%22">0960894X </searchLink><i>NLM ISO Abbreviation: </i>Bioorg Med Chem Lett <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=19097792 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.bmcl.2008.10.053 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 1026 Titles: – TitleFull: Identification of amidoheteroaryls as potent inhibitors of mutant (V600E) B-Raf kinase with in vivo activity. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Lyne PD – PersonEntity: Name: NameFull: Aquila B – PersonEntity: Name: NameFull: Cook DJ – PersonEntity: Name: NameFull: Dakin LA – PersonEntity: Name: NameFull: Ezhuthachan J – PersonEntity: Name: NameFull: Ioannidis S – PersonEntity: Name: NameFull: Pontz T – PersonEntity: Name: NameFull: Su M – PersonEntity: Name: NameFull: Ye Q – PersonEntity: Name: NameFull: Zheng X – PersonEntity: Name: NameFull: Block MH – PersonEntity: Name: NameFull: Cowen S – PersonEntity: Name: NameFull: Deegan TL – PersonEntity: Name: NameFull: Lee JW – PersonEntity: Name: NameFull: Scott DA – PersonEntity: Name: NameFull: Custeau D – PersonEntity: Name: NameFull: Drew L – PersonEntity: Name: NameFull: Poondru S – PersonEntity: Name: NameFull: Shen M – PersonEntity: Name: NameFull: Wu A IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 02 Text: 2009 Feb 01 Type: published Y: 2009 Identifiers: – Type: issn-electronic Value: 1464-3405 Numbering: – Type: volume Value: 19 – Type: issue Value: 3 Titles: – TitleFull: Bioorganic & medicinal chemistry letters Type: main |
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