Binding to the low-density lipoprotein receptor accelerates futile catalytic cycling in PCSK9 and raises the equilibrium level of intramolecular acylenzyme.

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Title: Binding to the low-density lipoprotein receptor accelerates futile catalytic cycling in PCSK9 and raises the equilibrium level of intramolecular acylenzyme.
Authors: Geoghegan KF; Pfizer Global Research and Development, Groton, Connecticut 06340, USA. kieran.f.geoghegan@pfizer.com, Hoth LR, Varghese AH, Lin W, Boyd JG, Griffor MC
Source: Biochemistry [Biochemistry] 2009 Apr 07; Vol. 48 (13), pp. 2941-9.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370623 Publication Model: Print Cited Medium: Internet ISSN: 1520-4995 (Electronic) Linking ISSN: 00062960 NLM ISO Abbreviation: Biochemistry Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Binding to the low-density lipoprotein receptor accelerates futile catalytic cycling in PCSK9 and raises the equilibrium level of intramolecular acylenzyme.
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  Data: <searchLink fieldCode="AU" term="%22Geoghegan+KF%22">Geoghegan KF</searchLink>; Pfizer Global Research and Development, Groton, Connecticut 06340, USA. kieran.f.geoghegan@pfizer.com<br /><searchLink fieldCode="AU" term="%22Hoth+LR%22">Hoth LR</searchLink><br /><searchLink fieldCode="AU" term="%22Varghese+AH%22">Varghese AH</searchLink><br /><searchLink fieldCode="AU" term="%22Lin+W%22">Lin W</searchLink><br /><searchLink fieldCode="AU" term="%22Boyd+JG%22">Boyd JG</searchLink><br /><searchLink fieldCode="AU" term="%22Griffor+MC%22">Griffor MC</searchLink>
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  Data: <searchLink fieldCode="JN" term="%220370623%22">Biochemistry</searchLink> [Biochemistry] 2009 Apr 07; Vol. 48 (13), pp. 2941-9.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0370623 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1520-4995 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200062960%22">00062960 </searchLink><i>NLM ISO Abbreviation: </i>Biochemistry <i>Subsets: </i>MEDLINE
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      – Type: doi
        Value: 10.1021/bi802232m
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      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 2941
    Titles:
      – TitleFull: Binding to the low-density lipoprotein receptor accelerates futile catalytic cycling in PCSK9 and raises the equilibrium level of intramolecular acylenzyme.
        Type: main
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            NameFull: Geoghegan KF
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            NameFull: Hoth LR
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            NameFull: Varghese AH
      – PersonEntity:
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            NameFull: Lin W
      – PersonEntity:
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            NameFull: Boyd JG
      – PersonEntity:
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            NameFull: Griffor MC
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          Dates:
            – D: 07
              M: 04
              Text: 2009 Apr 07
              Type: published
              Y: 2009
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              Value: 1520-4995
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              Value: 48
            – Type: issue
              Value: 13
          Titles:
            – TitleFull: Biochemistry
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