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The discovery and optimisation of pyrido[2,3-d]pyrimidine-2,4-diamines as potent and selective inhibitors of mTOR kinase.

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Title: The discovery and optimisation of pyrido[2,3-d]pyrimidine-2,4-diamines as potent and selective inhibitors of mTOR kinase.
Authors: Malagu K; KuDOS Pharmaceuticals Ltd, 410 Cambridge Science Park, Milton Road, Cambridge CB4 0WG, UK., Duggan H, Menear K, Hummersone M, Gomez S, Bailey C, Edwards P, Drzewiecki J, Leroux F, Quesada MJ, Hermann G, Maine S, Molyneaux CA, Le Gall A, Pullen J, Hickson I, Smith L, Maguire S, Martin N, Smith G, Pass M
Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2009 Oct 15; Vol. 19 (20), pp. 5950-3. Date of Electronic Publication: 2009 Aug 13.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE
Database: MEDLINE Ultimate
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An: 19762236
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PubType: Academic Journal
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  Data: <searchLink fieldCode="AU" term="%22Malagu+K%22">Malagu K</searchLink>; KuDOS Pharmaceuticals Ltd, 410 Cambridge Science Park, Milton Road, Cambridge CB4 0WG, UK.<br /><searchLink fieldCode="AU" term="%22Duggan+H%22">Duggan H</searchLink><br /><searchLink fieldCode="AU" term="%22Menear+K%22">Menear K</searchLink><br /><searchLink fieldCode="AU" term="%22Hummersone+M%22">Hummersone M</searchLink><br /><searchLink fieldCode="AU" term="%22Gomez+S%22">Gomez S</searchLink><br /><searchLink fieldCode="AU" term="%22Bailey+C%22">Bailey C</searchLink><br /><searchLink fieldCode="AU" term="%22Edwards+P%22">Edwards P</searchLink><br /><searchLink fieldCode="AU" term="%22Drzewiecki+J%22">Drzewiecki J</searchLink><br /><searchLink fieldCode="AU" term="%22Leroux+F%22">Leroux F</searchLink><br /><searchLink fieldCode="AU" term="%22Quesada+MJ%22">Quesada MJ</searchLink><br /><searchLink fieldCode="AU" term="%22Hermann+G%22">Hermann G</searchLink><br /><searchLink fieldCode="AU" term="%22Maine+S%22">Maine S</searchLink><br /><searchLink fieldCode="AU" term="%22Molyneaux+CA%22">Molyneaux CA</searchLink><br /><searchLink fieldCode="AU" term="%22Le+Gall+A%22">Le Gall A</searchLink><br /><searchLink fieldCode="AU" term="%22Pullen+J%22">Pullen J</searchLink><br /><searchLink fieldCode="AU" term="%22Hickson+I%22">Hickson I</searchLink><br /><searchLink fieldCode="AU" term="%22Smith+L%22">Smith L</searchLink><br /><searchLink fieldCode="AU" term="%22Maguire+S%22">Maguire S</searchLink><br /><searchLink fieldCode="AU" term="%22Martin+N%22">Martin N</searchLink><br /><searchLink fieldCode="AU" term="%22Smith+G%22">Smith G</searchLink><br /><searchLink fieldCode="AU" term="%22Pass+M%22">Pass M</searchLink>
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  Data: <searchLink fieldCode="JN" term="%229107377%22">Bioorganic & medicinal chemistry letters</searchLink> [Bioorg Med Chem Lett] 2009 Oct 15; Vol. 19 (20), pp. 5950-3. <i>Date of Electronic Publication: </i>2009 Aug 13.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science+Ltd%22">Elsevier Science Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9107377 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1464-3405 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%220960894X%22">0960894X </searchLink><i>NLM ISO Abbreviation: </i>Bioorg Med Chem Lett <i>Subsets: </i>MEDLINE
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              Text: 2009 Oct 15
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