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Benzodiazepine binding site occupancy by the novel GABAA receptor subtype-selective drug 7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine (TPA023) in rats, primates, and humans.

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Title: Benzodiazepine binding site occupancy by the novel GABAA receptor subtype-selective drug 7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine (TPA023) in rats, primates, and humans.
Authors: Atack JR; Merck Sharp & Dohme Research Laboratories, Neuroscience Research Centre, Harlow, Essex, United Kingdom. jatack1@its.jnj.com., Wong DF, Fryer TD, Ryan C, Sanabria S, Zhou Y, Dannals RF, Eng WS, Gibson RE, Burns HD, Vega JM, Vessy L, Scott-Stevens P, Beech JS, Baron JC, Sohal B, Schrag ML, Aigbirhio FI, McKernan RM, Hargreaves RJ
Source: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2010 Jan; Vol. 332 (1), pp. 17-25. Date of Electronic Publication: 2009 Sep 24.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0376362 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-0103 (Electronic) Linking ISSN: 00223565 NLM ISO Abbreviation: J Pharmacol Exp Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Benzodiazepine binding site occupancy by the novel GABAA receptor subtype-selective drug 7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine (TPA023) in rats, primates, and humans.
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  Data: <searchLink fieldCode="AU" term="%22Atack+JR%22">Atack JR</searchLink>; Merck Sharp & Dohme Research Laboratories, Neuroscience Research Centre, Harlow, Essex, United Kingdom. jatack1@its.jnj.com.<br /><searchLink fieldCode="AU" term="%22Wong+DF%22">Wong DF</searchLink><br /><searchLink fieldCode="AU" term="%22Fryer+TD%22">Fryer TD</searchLink><br /><searchLink fieldCode="AU" term="%22Ryan+C%22">Ryan C</searchLink><br /><searchLink fieldCode="AU" term="%22Sanabria+S%22">Sanabria S</searchLink><br /><searchLink fieldCode="AU" term="%22Zhou+Y%22">Zhou Y</searchLink><br /><searchLink fieldCode="AU" term="%22Dannals+RF%22">Dannals RF</searchLink><br /><searchLink fieldCode="AU" term="%22Eng+WS%22">Eng WS</searchLink><br /><searchLink fieldCode="AU" term="%22Gibson+RE%22">Gibson RE</searchLink><br /><searchLink fieldCode="AU" term="%22Burns+HD%22">Burns HD</searchLink><br /><searchLink fieldCode="AU" term="%22Vega+JM%22">Vega JM</searchLink><br /><searchLink fieldCode="AU" term="%22Vessy+L%22">Vessy L</searchLink><br /><searchLink fieldCode="AU" term="%22Scott-Stevens+P%22">Scott-Stevens P</searchLink><br /><searchLink fieldCode="AU" term="%22Beech+JS%22">Beech JS</searchLink><br /><searchLink fieldCode="AU" term="%22Baron+JC%22">Baron JC</searchLink><br /><searchLink fieldCode="AU" term="%22Sohal+B%22">Sohal B</searchLink><br /><searchLink fieldCode="AU" term="%22Schrag+ML%22">Schrag ML</searchLink><br /><searchLink fieldCode="AU" term="%22Aigbirhio+FI%22">Aigbirhio FI</searchLink><br /><searchLink fieldCode="AU" term="%22McKernan+RM%22">McKernan RM</searchLink><br /><searchLink fieldCode="AU" term="%22Hargreaves+RJ%22">Hargreaves RJ</searchLink>
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  Data: <searchLink fieldCode="JN" term="%220376362%22">The Journal of pharmacology and experimental therapeutics</searchLink> [J Pharmacol Exp Ther] 2010 Jan; Vol. 332 (1), pp. 17-25. <i>Date of Electronic Publication: </i>2009 Sep 24.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>0376362 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1521-0103 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200223565%22">00223565 </searchLink><i>NLM ISO Abbreviation: </i>J Pharmacol Exp Ther <i>Subsets: </i>MEDLINE
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