Analysis of imatinib and sorafenib binding to p38alpha compared with c-Abl and b-Raf provides structural insights for understanding the selectivity of inhibitors targeting the DFG-out form of protein kinases.
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| Title: | Analysis of imatinib and sorafenib binding to p38alpha compared with c-Abl and b-Raf provides structural insights for understanding the selectivity of inhibitors targeting the DFG-out form of protein kinases. |
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| Authors: | Namboodiri HV; Department of Biology, Locus Pharmaceuticals, Inc, Four Valley Square, 512 East Township Line Rd,Blue Bell, Pennsylvania 19422, USA. vnamboodiri@ansarisbio.com, Bukhtiyarova M, Ramcharan J, Karpusas M, Lee Y, Springman EB |
| Source: | Biochemistry [Biochemistry] 2010 May 04; Vol. 49 (17), pp. 3611-8. |
| Publication Type: | Comparative Study; Journal Article |
| Journal Info: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370623 Publication Model: Print Cited Medium: Internet ISSN: 1520-4995 (Electronic) Linking ISSN: 00062960 NLM ISO Abbreviation: Biochemistry Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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