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Discovery and synthesis of 6,7,8,9-tetrahydro-5H-pyrimido-[4,5-d]azepines as novel TRPV1 antagonists.

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Title: Discovery and synthesis of 6,7,8,9-tetrahydro-5H-pyrimido-[4,5-d]azepines as novel TRPV1 antagonists.
Authors: Hawryluk NA; Johnson & Johnson Pharmaceutical Research and Development LLC, San Diego, CA 92121, USA. nhawrylu@its.jnj.com, Merit JE, Lebsack AD, Branstetter BJ, Hack MD, Swanson N, Ao H, Maher MP, Bhattacharya A, Wang Q, Freedman JM, Scott BP, Wickenden AD, Chaplan SR, Breitenbucher JG
Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2010 Dec 01; Vol. 20 (23), pp. 7137-41. Date of Electronic Publication: 2010 Sep 17.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE
Database: MEDLINE Ultimate
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DbLabel: MEDLINE Ultimate
An: 20947352
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PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: Discovery and synthesis of 6,7,8,9-tetrahydro-5H-pyrimido-[4,5-d]azepines as novel TRPV1 antagonists.
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  Data: <searchLink fieldCode="AU" term="%22Hawryluk+NA%22">Hawryluk NA</searchLink>; Johnson & Johnson Pharmaceutical Research and Development LLC, San Diego, CA 92121, USA. nhawrylu@its.jnj.com<br /><searchLink fieldCode="AU" term="%22Merit+JE%22">Merit JE</searchLink><br /><searchLink fieldCode="AU" term="%22Lebsack+AD%22">Lebsack AD</searchLink><br /><searchLink fieldCode="AU" term="%22Branstetter+BJ%22">Branstetter BJ</searchLink><br /><searchLink fieldCode="AU" term="%22Hack+MD%22">Hack MD</searchLink><br /><searchLink fieldCode="AU" term="%22Swanson+N%22">Swanson N</searchLink><br /><searchLink fieldCode="AU" term="%22Ao+H%22">Ao H</searchLink><br /><searchLink fieldCode="AU" term="%22Maher+MP%22">Maher MP</searchLink><br /><searchLink fieldCode="AU" term="%22Bhattacharya+A%22">Bhattacharya A</searchLink><br /><searchLink fieldCode="AU" term="%22Wang+Q%22">Wang Q</searchLink><br /><searchLink fieldCode="AU" term="%22Freedman+JM%22">Freedman JM</searchLink><br /><searchLink fieldCode="AU" term="%22Scott+BP%22">Scott BP</searchLink><br /><searchLink fieldCode="AU" term="%22Wickenden+AD%22">Wickenden AD</searchLink><br /><searchLink fieldCode="AU" term="%22Chaplan+SR%22">Chaplan SR</searchLink><br /><searchLink fieldCode="AU" term="%22Breitenbucher+JG%22">Breitenbucher JG</searchLink>
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  Data: <searchLink fieldCode="JN" term="%229107377%22">Bioorganic & medicinal chemistry letters</searchLink> [Bioorg Med Chem Lett] 2010 Dec 01; Vol. 20 (23), pp. 7137-41. <i>Date of Electronic Publication: </i>2010 Sep 17.
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        Value: 10.1016/j.bmcl.2010.09.023
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        Text: English
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              Text: 2010 Dec 01
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