Discovery of 5-chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine (AZD1480) as a novel inhibitor of the Jak/Stat pathway.
Saved in:
| Title: | Discovery of 5-chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine (AZD1480) as a novel inhibitor of the Jak/Stat pathway. |
|---|---|
| Authors: | Ioannidis S; Department of Cancer Chemistry, AstraZeneca R&D, Boston, Massachusetts, United States. stephanos.ioannidis@astrazeneca.com, Lamb ML, Wang T, Almeida L, Block MH, Davies AM, Peng B, Su M, Zhang HJ, Hoffmann E, Rivard C, Green I, Howard T, Pollard H, Read J, Alimzhanov M, Bebernitz G, Bell K, Ye M, Huszar D, Zinda M |
| Source: | Journal of medicinal chemistry [J Med Chem] 2011 Jan 13; Vol. 54 (1), pp. 262-76. Date of Electronic Publication: 2010 Dec 07. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
|---|---|
| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 21138246 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: Discovery of 5-chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine (AZD1480) as a novel inhibitor of the Jak/Stat pathway. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Ioannidis+S%22">Ioannidis S</searchLink>; Department of Cancer Chemistry, AstraZeneca R&D, Boston, Massachusetts, United States. stephanos.ioannidis@astrazeneca.com<br /><searchLink fieldCode="AU" term="%22Lamb+ML%22">Lamb ML</searchLink><br /><searchLink fieldCode="AU" term="%22Wang+T%22">Wang T</searchLink><br /><searchLink fieldCode="AU" term="%22Almeida+L%22">Almeida L</searchLink><br /><searchLink fieldCode="AU" term="%22Block+MH%22">Block MH</searchLink><br /><searchLink fieldCode="AU" term="%22Davies+AM%22">Davies AM</searchLink><br /><searchLink fieldCode="AU" term="%22Peng+B%22">Peng B</searchLink><br /><searchLink fieldCode="AU" term="%22Su+M%22">Su M</searchLink><br /><searchLink fieldCode="AU" term="%22Zhang+HJ%22">Zhang HJ</searchLink><br /><searchLink fieldCode="AU" term="%22Hoffmann+E%22">Hoffmann E</searchLink><br /><searchLink fieldCode="AU" term="%22Rivard+C%22">Rivard C</searchLink><br /><searchLink fieldCode="AU" term="%22Green+I%22">Green I</searchLink><br /><searchLink fieldCode="AU" term="%22Howard+T%22">Howard T</searchLink><br /><searchLink fieldCode="AU" term="%22Pollard+H%22">Pollard H</searchLink><br /><searchLink fieldCode="AU" term="%22Read+J%22">Read J</searchLink><br /><searchLink fieldCode="AU" term="%22Alimzhanov+M%22">Alimzhanov M</searchLink><br /><searchLink fieldCode="AU" term="%22Bebernitz+G%22">Bebernitz G</searchLink><br /><searchLink fieldCode="AU" term="%22Bell+K%22">Bell K</searchLink><br /><searchLink fieldCode="AU" term="%22Ye+M%22">Ye M</searchLink><br /><searchLink fieldCode="AU" term="%22Huszar+D%22">Huszar D</searchLink><br /><searchLink fieldCode="AU" term="%22Zinda+M%22">Zinda M</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2011 Jan 13; Vol. 54 (1), pp. 262-76. <i>Date of Electronic Publication: </i>2010 Dec 07. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9716531 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1520-4804 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200222623%22">00222623 </searchLink><i>NLM ISO Abbreviation: </i>J Med Chem <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=21138246 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1021/jm1011319 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 262 Titles: – TitleFull: Discovery of 5-chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine (AZD1480) as a novel inhibitor of the Jak/Stat pathway. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Ioannidis S – PersonEntity: Name: NameFull: Lamb ML – PersonEntity: Name: NameFull: Wang T – PersonEntity: Name: NameFull: Almeida L – PersonEntity: Name: NameFull: Block MH – PersonEntity: Name: NameFull: Davies AM – PersonEntity: Name: NameFull: Peng B – PersonEntity: Name: NameFull: Su M – PersonEntity: Name: NameFull: Zhang HJ – PersonEntity: Name: NameFull: Hoffmann E – PersonEntity: Name: NameFull: Rivard C – PersonEntity: Name: NameFull: Green I – PersonEntity: Name: NameFull: Howard T – PersonEntity: Name: NameFull: Pollard H – PersonEntity: Name: NameFull: Read J – PersonEntity: Name: NameFull: Alimzhanov M – PersonEntity: Name: NameFull: Bebernitz G – PersonEntity: Name: NameFull: Bell K – PersonEntity: Name: NameFull: Ye M – PersonEntity: Name: NameFull: Huszar D – PersonEntity: Name: NameFull: Zinda M IsPartOfRelationships: – BibEntity: Dates: – D: 13 M: 01 Text: 2011 Jan 13 Type: published Y: 2011 Identifiers: – Type: issn-electronic Value: 1520-4804 Numbering: – Type: volume Value: 54 – Type: issue Value: 1 Titles: – TitleFull: Journal of medicinal chemistry Type: main |
| ResultId | 1 |
