Discovery of LY2457546: a multi-targeted anti-angiogenic kinase inhibitor with a novel spectrum of activity and exquisite potency in the acute myelogenous leukemia-Flt-3-internal tandem duplication mutant human tumor xenograft model.
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| Title: | Discovery of LY2457546: a multi-targeted anti-angiogenic kinase inhibitor with a novel spectrum of activity and exquisite potency in the acute myelogenous leukemia-Flt-3-internal tandem duplication mutant human tumor xenograft model. |
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| Authors: | Burkholder TP; Discovery Chemistry Research and Technology, Eli Lilly and Company, Indianapolis, IN, USA. tpb@lilly.com, Clayton JR, Rempala ME, Henry JR, Knobeloch JM, Mendel D, McLean JA, Hao Y, Barda DA, Considine EL, Uhlik MT, Chen Y, Ma L, Bloem LJ, Akunda JK, McCann DJ, Sanchez-Felix M, Clawson DK, Lahn MM, Starling JJ |
| Source: | Investigational new drugs [Invest New Drugs] 2012 Jun; Vol. 30 (3), pp. 936-49. Date of Electronic Publication: 2011 Mar 01. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Springer Country of Publication: United States NLM ID: 8309330 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-0646 (Electronic) Linking ISSN: 01676997 NLM ISO Abbreviation: Invest New Drugs Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 21360050 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Discovery of LY2457546: a multi-targeted anti-angiogenic kinase inhibitor with a novel spectrum of activity and exquisite potency in the acute myelogenous leukemia-Flt-3-internal tandem duplication mutant human tumor xenograft model. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Burkholder+TP%22">Burkholder TP</searchLink>; Discovery Chemistry Research and Technology, Eli Lilly and Company, Indianapolis, IN, USA. tpb@lilly.com<br /><searchLink fieldCode="AU" term="%22Clayton+JR%22">Clayton JR</searchLink><br /><searchLink fieldCode="AU" term="%22Rempala+ME%22">Rempala ME</searchLink><br /><searchLink fieldCode="AU" term="%22Henry+JR%22">Henry JR</searchLink><br /><searchLink fieldCode="AU" term="%22Knobeloch+JM%22">Knobeloch JM</searchLink><br /><searchLink fieldCode="AU" term="%22Mendel+D%22">Mendel D</searchLink><br /><searchLink fieldCode="AU" term="%22McLean+JA%22">McLean JA</searchLink><br /><searchLink fieldCode="AU" term="%22Hao+Y%22">Hao Y</searchLink><br /><searchLink fieldCode="AU" term="%22Barda+DA%22">Barda DA</searchLink><br /><searchLink fieldCode="AU" term="%22Considine+EL%22">Considine EL</searchLink><br /><searchLink fieldCode="AU" term="%22Uhlik+MT%22">Uhlik MT</searchLink><br /><searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink><br /><searchLink fieldCode="AU" term="%22Ma+L%22">Ma L</searchLink><br /><searchLink fieldCode="AU" term="%22Bloem+LJ%22">Bloem LJ</searchLink><br /><searchLink fieldCode="AU" term="%22Akunda+JK%22">Akunda JK</searchLink><br /><searchLink fieldCode="AU" term="%22McCann+DJ%22">McCann DJ</searchLink><br /><searchLink fieldCode="AU" term="%22Sanchez-Felix+M%22">Sanchez-Felix M</searchLink><br /><searchLink fieldCode="AU" term="%22Clawson+DK%22">Clawson DK</searchLink><br /><searchLink fieldCode="AU" term="%22Lahn+MM%22">Lahn MM</searchLink><br /><searchLink fieldCode="AU" term="%22Starling+JJ%22">Starling JJ</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%228309330%22">Investigational new drugs</searchLink> [Invest New Drugs] 2012 Jun; Vol. 30 (3), pp. 936-49. <i>Date of Electronic Publication: </i>2011 Mar 01. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Research Support, Non-U.S. Gov't – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer%22">Springer </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>8309330 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1573-0646 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2201676997%22">01676997 </searchLink><i>NLM ISO Abbreviation: </i>Invest New Drugs <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=21360050 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s10637-011-9640-6 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 936 Titles: – TitleFull: Discovery of LY2457546: a multi-targeted anti-angiogenic kinase inhibitor with a novel spectrum of activity and exquisite potency in the acute myelogenous leukemia-Flt-3-internal tandem duplication mutant human tumor xenograft model. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Burkholder TP – PersonEntity: Name: NameFull: Clayton JR – PersonEntity: Name: NameFull: Rempala ME – PersonEntity: Name: NameFull: Henry JR – PersonEntity: Name: NameFull: Knobeloch JM – PersonEntity: Name: NameFull: Mendel D – PersonEntity: Name: NameFull: McLean JA – PersonEntity: Name: NameFull: Hao Y – PersonEntity: Name: NameFull: Barda DA – PersonEntity: Name: NameFull: Considine EL – PersonEntity: Name: NameFull: Uhlik MT – PersonEntity: Name: NameFull: Chen Y – PersonEntity: Name: NameFull: Ma L – PersonEntity: Name: NameFull: Bloem LJ – PersonEntity: Name: NameFull: Akunda JK – PersonEntity: Name: NameFull: McCann DJ – PersonEntity: Name: NameFull: Sanchez-Felix M – PersonEntity: Name: NameFull: Clawson DK – PersonEntity: Name: NameFull: Lahn MM – PersonEntity: Name: NameFull: Starling JJ IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 06 Text: 2012 Jun Type: published Y: 2012 Identifiers: – Type: issn-electronic Value: 1573-0646 Numbering: – Type: volume Value: 30 – Type: issue Value: 3 Titles: – TitleFull: Investigational new drugs Type: main |
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