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Discovery of fused bicyclic agonists of the orphan G-protein coupled receptor GPR119 with in vivo activity in rodent models of glucose control.

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Title: Discovery of fused bicyclic agonists of the orphan G-protein coupled receptor GPR119 with in vivo activity in rodent models of glucose control.
Authors: Semple G; Medicinal Chemistry, Arena Pharmaceuticals, 6166 Nancy Ridge Drive, San Diego, CA 92121, USA. gsemple@arenapharm.com, Ren A, Fioravanti B, Pereira G, Calderon I, Choi K, Xiong Y, Shin YJ, Gharbaoui T, Sage CR, Morgan M, Xing C, Chu ZL, Leonard JN, Grottick AJ, Al-Shamma H, Liang Y, Demarest KT, Jones RM
Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2011 May 15; Vol. 21 (10), pp. 3134-41. Date of Electronic Publication: 2011 Mar 13.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Discovery of fused bicyclic agonists of the orphan G-protein coupled receptor GPR119 with in vivo activity in rodent models of glucose control.
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  Data: <searchLink fieldCode="AU" term="%22Semple+G%22">Semple G</searchLink>; Medicinal Chemistry, Arena Pharmaceuticals, 6166 Nancy Ridge Drive, San Diego, CA 92121, USA. gsemple@arenapharm.com<br /><searchLink fieldCode="AU" term="%22Ren+A%22">Ren A</searchLink><br /><searchLink fieldCode="AU" term="%22Fioravanti+B%22">Fioravanti B</searchLink><br /><searchLink fieldCode="AU" term="%22Pereira+G%22">Pereira G</searchLink><br /><searchLink fieldCode="AU" term="%22Calderon+I%22">Calderon I</searchLink><br /><searchLink fieldCode="AU" term="%22Choi+K%22">Choi K</searchLink><br /><searchLink fieldCode="AU" term="%22Xiong+Y%22">Xiong Y</searchLink><br /><searchLink fieldCode="AU" term="%22Shin+YJ%22">Shin YJ</searchLink><br /><searchLink fieldCode="AU" term="%22Gharbaoui+T%22">Gharbaoui T</searchLink><br /><searchLink fieldCode="AU" term="%22Sage+CR%22">Sage CR</searchLink><br /><searchLink fieldCode="AU" term="%22Morgan+M%22">Morgan M</searchLink><br /><searchLink fieldCode="AU" term="%22Xing+C%22">Xing C</searchLink><br /><searchLink fieldCode="AU" term="%22Chu+ZL%22">Chu ZL</searchLink><br /><searchLink fieldCode="AU" term="%22Leonard+JN%22">Leonard JN</searchLink><br /><searchLink fieldCode="AU" term="%22Grottick+AJ%22">Grottick AJ</searchLink><br /><searchLink fieldCode="AU" term="%22Al-Shamma+H%22">Al-Shamma H</searchLink><br /><searchLink fieldCode="AU" term="%22Liang+Y%22">Liang Y</searchLink><br /><searchLink fieldCode="AU" term="%22Demarest+KT%22">Demarest KT</searchLink><br /><searchLink fieldCode="AU" term="%22Jones+RM%22">Jones RM</searchLink>
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  Data: <searchLink fieldCode="JN" term="%229107377%22">Bioorganic & medicinal chemistry letters</searchLink> [Bioorg Med Chem Lett] 2011 May 15; Vol. 21 (10), pp. 3134-41. <i>Date of Electronic Publication: </i>2011 Mar 13.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science+Ltd%22">Elsevier Science Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9107377 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1464-3405 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%220960894X%22">0960894X </searchLink><i>NLM ISO Abbreviation: </i>Bioorg Med Chem Lett <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=21444206
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