The carriage of risk variants of CDKAL1 impairs beta-cell function in both diabetic and non-diabetic patients and reduces response to non-sulfonylurea and sulfonylurea agonists of the pancreatic KATP channel. - Chistiakov DA; Potapov VA; Smetanina SA; Bel'chikova LN; Suplotova LA; Nosikov VV (Acta diabetologica, 2011)