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Discovery of (+)-N-(3-aminopropyl)-N-[1-(5-benzyl-3-methyl-4-oxo-[1,2]thiazolo[5,4-d]pyrimidin-6-yl)-2-methylpropyl]-4-methylbenzamide (AZD4877), a kinesin spindle protein inhibitor and potential anticancer agent.

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Title: Discovery of (+)-N-(3-aminopropyl)-N-[1-(5-benzyl-3-methyl-4-oxo-[1,2]thiazolo[5,4-d]pyrimidin-6-yl)-2-methylpropyl]-4-methylbenzamide (AZD4877), a kinesin spindle protein inhibitor and potential anticancer agent.
Authors: Theoclitou ME; Cancer & Infection Research Area, AstraZeneca, Alderley Park, Macclesfield, Cheshire, SK10 4TG, United Kingdom. Maria-Elena.Theoclitou@astrazeneca.com, Aquila B, Block MH, Brassil PJ, Castriotta L, Code E, Collins MP, Davies AM, Deegan T, Ezhuthachan J, Filla S, Freed E, Hu H, Huszar D, Jayaraman M, Lawson D, Lewis PM, Nadella MV, Oza V, Padmanilayam M, Pontz T, Ronco L, Russell D, Whitston D, Zheng X
Source: Journal of medicinal chemistry [J Med Chem] 2011 Oct 13; Vol. 54 (19), pp. 6734-50. Date of Electronic Publication: 2011 Sep 07.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Discovery of (+)-N-(3-aminopropyl)-N-[1-(5-benzyl-3-methyl-4-oxo-[1,2]thiazolo[5,4-d]pyrimidin-6-yl)-2-methylpropyl]-4-methylbenzamide (AZD4877), a kinesin spindle protein inhibitor and potential anticancer agent.
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  Data: <searchLink fieldCode="AU" term="%22Theoclitou+ME%22">Theoclitou ME</searchLink>; Cancer & Infection Research Area, AstraZeneca, Alderley Park, Macclesfield, Cheshire, SK10 4TG, United Kingdom. Maria-Elena.Theoclitou@astrazeneca.com<br /><searchLink fieldCode="AU" term="%22Aquila+B%22">Aquila B</searchLink><br /><searchLink fieldCode="AU" term="%22Block+MH%22">Block MH</searchLink><br /><searchLink fieldCode="AU" term="%22Brassil+PJ%22">Brassil PJ</searchLink><br /><searchLink fieldCode="AU" term="%22Castriotta+L%22">Castriotta L</searchLink><br /><searchLink fieldCode="AU" term="%22Code+E%22">Code E</searchLink><br /><searchLink fieldCode="AU" term="%22Collins+MP%22">Collins MP</searchLink><br /><searchLink fieldCode="AU" term="%22Davies+AM%22">Davies AM</searchLink><br /><searchLink fieldCode="AU" term="%22Deegan+T%22">Deegan T</searchLink><br /><searchLink fieldCode="AU" term="%22Ezhuthachan+J%22">Ezhuthachan J</searchLink><br /><searchLink fieldCode="AU" term="%22Filla+S%22">Filla S</searchLink><br /><searchLink fieldCode="AU" term="%22Freed+E%22">Freed E</searchLink><br /><searchLink fieldCode="AU" term="%22Hu+H%22">Hu H</searchLink><br /><searchLink fieldCode="AU" term="%22Huszar+D%22">Huszar D</searchLink><br /><searchLink fieldCode="AU" term="%22Jayaraman+M%22">Jayaraman M</searchLink><br /><searchLink fieldCode="AU" term="%22Lawson+D%22">Lawson D</searchLink><br /><searchLink fieldCode="AU" term="%22Lewis+PM%22">Lewis PM</searchLink><br /><searchLink fieldCode="AU" term="%22Nadella+MV%22">Nadella MV</searchLink><br /><searchLink fieldCode="AU" term="%22Oza+V%22">Oza V</searchLink><br /><searchLink fieldCode="AU" term="%22Padmanilayam+M%22">Padmanilayam M</searchLink><br /><searchLink fieldCode="AU" term="%22Pontz+T%22">Pontz T</searchLink><br /><searchLink fieldCode="AU" term="%22Ronco+L%22">Ronco L</searchLink><br /><searchLink fieldCode="AU" term="%22Russell+D%22">Russell D</searchLink><br /><searchLink fieldCode="AU" term="%22Whitston+D%22">Whitston D</searchLink><br /><searchLink fieldCode="AU" term="%22Zheng+X%22">Zheng X</searchLink>
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  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2011 Oct 13; Vol. 54 (19), pp. 6734-50. <i>Date of Electronic Publication: </i>2011 Sep 07.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9716531 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1520-4804 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200222623%22">00222623 </searchLink><i>NLM ISO Abbreviation: </i>J Med Chem <i>Subsets: </i>MEDLINE
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