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Metabolism-directed design of oxetane-containing arylsulfonamide derivatives as γ-secretase inhibitors.

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Title: Metabolism-directed design of oxetane-containing arylsulfonamide derivatives as γ-secretase inhibitors.
Authors: Stepan AF; Pfizer Worldwide Research & Development, Eastern Point Road, Groton, Connecticut 06340, United States. Antonia.Stepan@pfizer.com, Karki K, McDonald WS, Dorff PH, Dutra JK, Dirico KJ, Won A, Subramanyam C, Efremov IV, O'Donnell CJ, Nolan CE, Becker SL, Pustilnik LR, Sneed B, Sun H, Lu Y, Robshaw AE, Riddell D, O'Sullivan TJ, Sibley E, Capetta S, Atchison K, Hallgren AJ, Miller E, Wood A, Obach RS
Source: Journal of medicinal chemistry [J Med Chem] 2011 Nov 24; Vol. 54 (22), pp. 7772-83. Date of Electronic Publication: 2011 Oct 26.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: <searchLink fieldCode="AU" term="%22Stepan+AF%22">Stepan AF</searchLink>; Pfizer Worldwide Research & Development, Eastern Point Road, Groton, Connecticut 06340, United States. Antonia.Stepan@pfizer.com<br /><searchLink fieldCode="AU" term="%22Karki+K%22">Karki K</searchLink><br /><searchLink fieldCode="AU" term="%22McDonald+WS%22">McDonald WS</searchLink><br /><searchLink fieldCode="AU" term="%22Dorff+PH%22">Dorff PH</searchLink><br /><searchLink fieldCode="AU" term="%22Dutra+JK%22">Dutra JK</searchLink><br /><searchLink fieldCode="AU" term="%22Dirico+KJ%22">Dirico KJ</searchLink><br /><searchLink fieldCode="AU" term="%22Won+A%22">Won A</searchLink><br /><searchLink fieldCode="AU" term="%22Subramanyam+C%22">Subramanyam C</searchLink><br /><searchLink fieldCode="AU" term="%22Efremov+IV%22">Efremov IV</searchLink><br /><searchLink fieldCode="AU" term="%22O'Donnell+CJ%22">O'Donnell CJ</searchLink><br /><searchLink fieldCode="AU" term="%22Nolan+CE%22">Nolan CE</searchLink><br /><searchLink fieldCode="AU" term="%22Becker+SL%22">Becker SL</searchLink><br /><searchLink fieldCode="AU" term="%22Pustilnik+LR%22">Pustilnik LR</searchLink><br /><searchLink fieldCode="AU" term="%22Sneed+B%22">Sneed B</searchLink><br /><searchLink fieldCode="AU" term="%22Sun+H%22">Sun H</searchLink><br /><searchLink fieldCode="AU" term="%22Lu+Y%22">Lu Y</searchLink><br /><searchLink fieldCode="AU" term="%22Robshaw+AE%22">Robshaw AE</searchLink><br /><searchLink fieldCode="AU" term="%22Riddell+D%22">Riddell D</searchLink><br /><searchLink fieldCode="AU" term="%22O'Sullivan+TJ%22">O'Sullivan TJ</searchLink><br /><searchLink fieldCode="AU" term="%22Sibley+E%22">Sibley E</searchLink><br /><searchLink fieldCode="AU" term="%22Capetta+S%22">Capetta S</searchLink><br /><searchLink fieldCode="AU" term="%22Atchison+K%22">Atchison K</searchLink><br /><searchLink fieldCode="AU" term="%22Hallgren+AJ%22">Hallgren AJ</searchLink><br /><searchLink fieldCode="AU" term="%22Miller+E%22">Miller E</searchLink><br /><searchLink fieldCode="AU" term="%22Wood+A%22">Wood A</searchLink><br /><searchLink fieldCode="AU" term="%22Obach+RS%22">Obach RS</searchLink>
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  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2011 Nov 24; Vol. 54 (22), pp. 7772-83. <i>Date of Electronic Publication: </i>2011 Oct 26.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9716531 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1520-4804 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200222623%22">00222623 </searchLink><i>NLM ISO Abbreviation: </i>J Med Chem <i>Subsets: </i>MEDLINE
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              Text: 2011 Nov 24
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