ABT-737 synergizes with bortezomib to induce apoptosis, mediated by Bid cleavage, Bax activation, and mitochondrial dysfunction in an Akt-dependent context in malignant human glioma cell lines.

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Title: ABT-737 synergizes with bortezomib to induce apoptosis, mediated by Bid cleavage, Bax activation, and mitochondrial dysfunction in an Akt-dependent context in malignant human glioma cell lines.
Authors: Premkumar DR; Department of Neurosurgery, Children's Hospital of Pittsburgh, 4401 Penn Avenue, Pittsburgh, PA 15224, USA., Jane EP, DiDomenico JD, Vukmer NA, Agostino NR, Pollack IF
Source: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2012 Jun; Vol. 341 (3), pp. 859-72. Date of Electronic Publication: 2012 Mar 05.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0376362 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-0103 (Electronic) Linking ISSN: 00223565 NLM ISO Abbreviation: J Pharmacol Exp Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
PubTypeId: academicJournal
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  Data: ABT-737 synergizes with bortezomib to induce apoptosis, mediated by Bid cleavage, Bax activation, and mitochondrial dysfunction in an Akt-dependent context in malignant human glioma cell lines.
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  Data: <searchLink fieldCode="AU" term="%22Premkumar+DR%22">Premkumar DR</searchLink>; Department of Neurosurgery, Children's Hospital of Pittsburgh, 4401 Penn Avenue, Pittsburgh, PA 15224, USA.<br /><searchLink fieldCode="AU" term="%22Jane+EP%22">Jane EP</searchLink><br /><searchLink fieldCode="AU" term="%22DiDomenico+JD%22">DiDomenico JD</searchLink><br /><searchLink fieldCode="AU" term="%22Vukmer+NA%22">Vukmer NA</searchLink><br /><searchLink fieldCode="AU" term="%22Agostino+NR%22">Agostino NR</searchLink><br /><searchLink fieldCode="AU" term="%22Pollack+IF%22">Pollack IF</searchLink>
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  Data: <searchLink fieldCode="JN" term="%220376362%22">The Journal of pharmacology and experimental therapeutics</searchLink> [J Pharmacol Exp Ther] 2012 Jun; Vol. 341 (3), pp. 859-72. <i>Date of Electronic Publication: </i>2012 Mar 05.
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  Data: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>0376362 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1521-0103 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200223565%22">00223565 </searchLink><i>NLM ISO Abbreviation: </i>J Pharmacol Exp Ther <i>Subsets: </i>MEDLINE
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        Value: 10.1124/jpet.112.191536
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      – Code: eng
        Text: English
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        StartPage: 859
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      – TitleFull: ABT-737 synergizes with bortezomib to induce apoptosis, mediated by Bid cleavage, Bax activation, and mitochondrial dysfunction in an Akt-dependent context in malignant human glioma cell lines.
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            NameFull: Premkumar DR
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            NameFull: Jane EP
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            NameFull: DiDomenico JD
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            NameFull: Vukmer NA
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              Text: 2012 Jun
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              Y: 2012
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              Value: 341
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