View in EDS

Application of the bicyclo[1.1.1]pentane motif as a nonclassical phenyl ring bioisostere in the design of a potent and orally active γ-secretase inhibitor.

Saved in:
Bibliographic Details
Title: Application of the bicyclo[1.1.1]pentane motif as a nonclassical phenyl ring bioisostere in the design of a potent and orally active γ-secretase inhibitor.
Authors: Stepan AF; Pfizer Worldwide Research & Development, Eastern Point Road, Groton, Connecticut 06340, USA. Antonia.Stepan@pfizer.com, Subramanyam C, Efremov IV, Dutra JK, O'Sullivan TJ, DiRico KJ, McDonald WS, Won A, Dorff PH, Nolan CE, Becker SL, Pustilnik LR, Riddell DR, Kauffman GW, Kormos BL, Zhang L, Lu Y, Capetta SH, Green ME, Karki K, Sibley E, Atchison KP, Hallgren AJ, Oborski CE, Robshaw AE, Sneed B, O'Donnell CJ
Source: Journal of medicinal chemistry [J Med Chem] 2012 Apr 12; Vol. 55 (7), pp. 3414-24. Date of Electronic Publication: 2012 Mar 29.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 22420884
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Application of the bicyclo[1.1.1]pentane motif as a nonclassical phenyl ring bioisostere in the design of a potent and orally active γ-secretase inhibitor.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Stepan+AF%22">Stepan AF</searchLink>; Pfizer Worldwide Research & Development, Eastern Point Road, Groton, Connecticut 06340, USA. Antonia.Stepan@pfizer.com<br /><searchLink fieldCode="AU" term="%22Subramanyam+C%22">Subramanyam C</searchLink><br /><searchLink fieldCode="AU" term="%22Efremov+IV%22">Efremov IV</searchLink><br /><searchLink fieldCode="AU" term="%22Dutra+JK%22">Dutra JK</searchLink><br /><searchLink fieldCode="AU" term="%22O'Sullivan+TJ%22">O'Sullivan TJ</searchLink><br /><searchLink fieldCode="AU" term="%22DiRico+KJ%22">DiRico KJ</searchLink><br /><searchLink fieldCode="AU" term="%22McDonald+WS%22">McDonald WS</searchLink><br /><searchLink fieldCode="AU" term="%22Won+A%22">Won A</searchLink><br /><searchLink fieldCode="AU" term="%22Dorff+PH%22">Dorff PH</searchLink><br /><searchLink fieldCode="AU" term="%22Nolan+CE%22">Nolan CE</searchLink><br /><searchLink fieldCode="AU" term="%22Becker+SL%22">Becker SL</searchLink><br /><searchLink fieldCode="AU" term="%22Pustilnik+LR%22">Pustilnik LR</searchLink><br /><searchLink fieldCode="AU" term="%22Riddell+DR%22">Riddell DR</searchLink><br /><searchLink fieldCode="AU" term="%22Kauffman+GW%22">Kauffman GW</searchLink><br /><searchLink fieldCode="AU" term="%22Kormos+BL%22">Kormos BL</searchLink><br /><searchLink fieldCode="AU" term="%22Zhang+L%22">Zhang L</searchLink><br /><searchLink fieldCode="AU" term="%22Lu+Y%22">Lu Y</searchLink><br /><searchLink fieldCode="AU" term="%22Capetta+SH%22">Capetta SH</searchLink><br /><searchLink fieldCode="AU" term="%22Green+ME%22">Green ME</searchLink><br /><searchLink fieldCode="AU" term="%22Karki+K%22">Karki K</searchLink><br /><searchLink fieldCode="AU" term="%22Sibley+E%22">Sibley E</searchLink><br /><searchLink fieldCode="AU" term="%22Atchison+KP%22">Atchison KP</searchLink><br /><searchLink fieldCode="AU" term="%22Hallgren+AJ%22">Hallgren AJ</searchLink><br /><searchLink fieldCode="AU" term="%22Oborski+CE%22">Oborski CE</searchLink><br /><searchLink fieldCode="AU" term="%22Robshaw+AE%22">Robshaw AE</searchLink><br /><searchLink fieldCode="AU" term="%22Sneed+B%22">Sneed B</searchLink><br /><searchLink fieldCode="AU" term="%22O'Donnell+CJ%22">O'Donnell CJ</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2012 Apr 12; Vol. 55 (7), pp. 3414-24. <i>Date of Electronic Publication: </i>2012 Mar 29.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9716531 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1520-4804 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200222623%22">00222623 </searchLink><i>NLM ISO Abbreviation: </i>J Med Chem <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=22420884
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1021/jm300094u
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 3414
    Titles:
      – TitleFull: Application of the bicyclo[1.1.1]pentane motif as a nonclassical phenyl ring bioisostere in the design of a potent and orally active γ-secretase inhibitor.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Stepan AF
      – PersonEntity:
          Name:
            NameFull: Subramanyam C
      – PersonEntity:
          Name:
            NameFull: Efremov IV
      – PersonEntity:
          Name:
            NameFull: Dutra JK
      – PersonEntity:
          Name:
            NameFull: O'Sullivan TJ
      – PersonEntity:
          Name:
            NameFull: DiRico KJ
      – PersonEntity:
          Name:
            NameFull: McDonald WS
      – PersonEntity:
          Name:
            NameFull: Won A
      – PersonEntity:
          Name:
            NameFull: Dorff PH
      – PersonEntity:
          Name:
            NameFull: Nolan CE
      – PersonEntity:
          Name:
            NameFull: Becker SL
      – PersonEntity:
          Name:
            NameFull: Pustilnik LR
      – PersonEntity:
          Name:
            NameFull: Riddell DR
      – PersonEntity:
          Name:
            NameFull: Kauffman GW
      – PersonEntity:
          Name:
            NameFull: Kormos BL
      – PersonEntity:
          Name:
            NameFull: Zhang L
      – PersonEntity:
          Name:
            NameFull: Lu Y
      – PersonEntity:
          Name:
            NameFull: Capetta SH
      – PersonEntity:
          Name:
            NameFull: Green ME
      – PersonEntity:
          Name:
            NameFull: Karki K
      – PersonEntity:
          Name:
            NameFull: Sibley E
      – PersonEntity:
          Name:
            NameFull: Atchison KP
      – PersonEntity:
          Name:
            NameFull: Hallgren AJ
      – PersonEntity:
          Name:
            NameFull: Oborski CE
      – PersonEntity:
          Name:
            NameFull: Robshaw AE
      – PersonEntity:
          Name:
            NameFull: Sneed B
      – PersonEntity:
          Name:
            NameFull: O'Donnell CJ
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 12
              M: 04
              Text: 2012 Apr 12
              Type: published
              Y: 2012
          Identifiers:
            – Type: issn-electronic
              Value: 1520-4804
          Numbering:
            – Type: volume
              Value: 55
            – Type: issue
              Value: 7
          Titles:
            – TitleFull: Journal of medicinal chemistry
              Type: main
ResultId 1