Familial secondary erythrocytosis due to increased oxygen affinity is caused by destabilization of the T state of hemoglobin Brigham (α₂β₂(Pro100Leu)). - Mollan TL; Abraham B; Strader MB; Jia Y; Lozier JN; Olson JS; Alayash AI (Protein science : a publication of the Protein Society, 2012)