A new family of covalent inhibitors block nucleotide binding to the active site of pyruvate kinase. - Morgan HP; Walsh MJ; Blackburn EA; Wear MA; Boxer MB; Shen M; Veith H; McNae IW; Nowicki MW; Michels PA; Auld DS; Fothergill-Gilmore LA; et al. (The Biochemical journal, 2012)