In medication-overuse headache, fMRI shows long-lasting dysfunction in midbrain areas. - Ferraro S; Grazzi L; Muffatti R; Nava S; Ghielmetti F; Bertolino N; Mandelli ML; Visintin E; Bruzzone MG; Nigri A; Epifani F; Bussone G; et al. (Headache, 2012)