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Discovery of novel, induced-pocket binding oxazolidinones as potent, selective, and orally bioavailable tankyrase inhibitors.

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Title: Discovery of novel, induced-pocket binding oxazolidinones as potent, selective, and orally bioavailable tankyrase inhibitors.
Authors: Bregman H; Department of Chemistry Research and Discovery, Amgen Inc., 360 Binney Street, Cambridge, Massachusetts 02142, USA. hbregman@amgen.com, Chakka N, Guzman-Perez A, Gunaydin H, Gu Y, Huang X, Berry V, Liu J, Teffera Y, Huang L, Egge B, Mullady EL, Schneider S, Andrews PS, Mishra A, Newcomb J, Serafino R, Strathdee CA, Turci SM, Wilson C, DiMauro EF
Source: Journal of medicinal chemistry [J Med Chem] 2013 Jun 13; Vol. 56 (11), pp. 4320-42. Date of Electronic Publication: 2013 May 23.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Discovery of novel, induced-pocket binding oxazolidinones as potent, selective, and orally bioavailable tankyrase inhibitors.
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  Data: <searchLink fieldCode="AU" term="%22Bregman+H%22">Bregman H</searchLink>; Department of Chemistry Research and Discovery, Amgen Inc., 360 Binney Street, Cambridge, Massachusetts 02142, USA. hbregman@amgen.com<br /><searchLink fieldCode="AU" term="%22Chakka+N%22">Chakka N</searchLink><br /><searchLink fieldCode="AU" term="%22Guzman-Perez+A%22">Guzman-Perez A</searchLink><br /><searchLink fieldCode="AU" term="%22Gunaydin+H%22">Gunaydin H</searchLink><br /><searchLink fieldCode="AU" term="%22Gu+Y%22">Gu Y</searchLink><br /><searchLink fieldCode="AU" term="%22Huang+X%22">Huang X</searchLink><br /><searchLink fieldCode="AU" term="%22Berry+V%22">Berry V</searchLink><br /><searchLink fieldCode="AU" term="%22Liu+J%22">Liu J</searchLink><br /><searchLink fieldCode="AU" term="%22Teffera+Y%22">Teffera Y</searchLink><br /><searchLink fieldCode="AU" term="%22Huang+L%22">Huang L</searchLink><br /><searchLink fieldCode="AU" term="%22Egge+B%22">Egge B</searchLink><br /><searchLink fieldCode="AU" term="%22Mullady+EL%22">Mullady EL</searchLink><br /><searchLink fieldCode="AU" term="%22Schneider+S%22">Schneider S</searchLink><br /><searchLink fieldCode="AU" term="%22Andrews+PS%22">Andrews PS</searchLink><br /><searchLink fieldCode="AU" term="%22Mishra+A%22">Mishra A</searchLink><br /><searchLink fieldCode="AU" term="%22Newcomb+J%22">Newcomb J</searchLink><br /><searchLink fieldCode="AU" term="%22Serafino+R%22">Serafino R</searchLink><br /><searchLink fieldCode="AU" term="%22Strathdee+CA%22">Strathdee CA</searchLink><br /><searchLink fieldCode="AU" term="%22Turci+SM%22">Turci SM</searchLink><br /><searchLink fieldCode="AU" term="%22Wilson+C%22">Wilson C</searchLink><br /><searchLink fieldCode="AU" term="%22DiMauro+EF%22">DiMauro EF</searchLink>
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  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2013 Jun 13; Vol. 56 (11), pp. 4320-42. <i>Date of Electronic Publication: </i>2013 May 23.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9716531 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1520-4804 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200222623%22">00222623 </searchLink><i>NLM ISO Abbreviation: </i>J Med Chem <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=23701517
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        Value: 10.1021/jm4000038
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        Text: English
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              Text: 2013 Jun 13
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              Y: 2013
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