Treatment with a histone deacetylase inhibitor, valproic acid, is associated with increased platelet activation in a large animal model of traumatic brain injury and hemorrhagic shock.

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Title: Treatment with a histone deacetylase inhibitor, valproic acid, is associated with increased platelet activation in a large animal model of traumatic brain injury and hemorrhagic shock.
Authors: Dekker SE; Department of Surgery, University of Michigan Hospital, Ann Arbor, Michigan; Department of Anesthesiology, VU University Medical Center, Institute for Cardiovascular Research, Amsterdam, the Netherlands., Sillesen M; Division of Trauma, Emergency Surgery And Surgical Critical Care, Department of Surgery, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts; Department of Surgery, Copenhagen University Hospital, Hillerød, Denmark., Bambakidis T; Department of Surgery, University of Michigan Hospital, Ann Arbor, Michigan., Andjelkovic AV; Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, Michigan., Jin G; Department of Surgery, University of Michigan Hospital, Ann Arbor, Michigan., Liu B; Department of Surgery, University of Michigan Hospital, Ann Arbor, Michigan., Boer C; Department of Anesthesiology, VU University Medical Center, Institute for Cardiovascular Research, Amsterdam, the Netherlands., Johansson PI; Capital Region Blood Bank, University of Copenhagen, Rigshospitalet, Denmark; Department of Surgery, University of Texas Medical School, Centre for Translational Injury Research (CeTIR), Houston, Texas., Linzel D; Department of Surgery, University of Michigan Hospital, Ann Arbor, Michigan; Department of Emergency Medicine, VU University Medical Center, Amsterdam, the Netherlands., Halaweish I; Department of Surgery, University of Michigan Hospital, Ann Arbor, Michigan., Alam HB; Department of Surgery, University of Michigan Hospital, Ann Arbor, Michigan. Electronic address: alamh@med.umich.edu.
Source: The Journal of surgical research [J Surg Res] 2014 Jul; Vol. 190 (1), pp. 312-8. Date of Electronic Publication: 2014 Mar 01.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: Academic Press Country of Publication: United States NLM ID: 0376340 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-8673 (Electronic) Linking ISSN: 00224804 NLM ISO Abbreviation: J Surg Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Treatment with a histone deacetylase inhibitor, valproic acid, is associated with increased platelet activation in a large animal model of traumatic brain injury and hemorrhagic shock.
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  Data: <searchLink fieldCode="AU" term="%22Dekker+SE%22">Dekker SE</searchLink>; Department of Surgery, University of Michigan Hospital, Ann Arbor, Michigan; Department of Anesthesiology, VU University Medical Center, Institute for Cardiovascular Research, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Sillesen+M%22">Sillesen M</searchLink>; Division of Trauma, Emergency Surgery And Surgical Critical Care, Department of Surgery, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts; Department of Surgery, Copenhagen University Hospital, Hillerød, Denmark.<br /><searchLink fieldCode="AU" term="%22Bambakidis+T%22">Bambakidis T</searchLink>; Department of Surgery, University of Michigan Hospital, Ann Arbor, Michigan.<br /><searchLink fieldCode="AU" term="%22Andjelkovic+AV%22">Andjelkovic AV</searchLink>; Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, Michigan.<br /><searchLink fieldCode="AU" term="%22Jin+G%22">Jin G</searchLink>; Department of Surgery, University of Michigan Hospital, Ann Arbor, Michigan.<br /><searchLink fieldCode="AU" term="%22Liu+B%22">Liu B</searchLink>; Department of Surgery, University of Michigan Hospital, Ann Arbor, Michigan.<br /><searchLink fieldCode="AU" term="%22Boer+C%22">Boer C</searchLink>; Department of Anesthesiology, VU University Medical Center, Institute for Cardiovascular Research, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Johansson+PI%22">Johansson PI</searchLink>; Capital Region Blood Bank, University of Copenhagen, Rigshospitalet, Denmark; Department of Surgery, University of Texas Medical School, Centre for Translational Injury Research (CeTIR), Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Linzel+D%22">Linzel D</searchLink>; Department of Surgery, University of Michigan Hospital, Ann Arbor, Michigan; Department of Emergency Medicine, VU University Medical Center, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Halaweish+I%22">Halaweish I</searchLink>; Department of Surgery, University of Michigan Hospital, Ann Arbor, Michigan.<br /><searchLink fieldCode="AU" term="%22Alam+HB%22">Alam HB</searchLink>; Department of Surgery, University of Michigan Hospital, Ann Arbor, Michigan. Electronic address: alamh@med.umich.edu.
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  Data: <searchLink fieldCode="JN" term="%220376340%22">The Journal of surgical research</searchLink> [J Surg Res] 2014 Jul; Vol. 190 (1), pp. 312-8. <i>Date of Electronic Publication: </i>2014 Mar 01.
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  Data: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Academic+Press%22">Academic Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0376340 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1095-8673 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200224804%22">00224804 </searchLink><i>NLM ISO Abbreviation: </i>J Surg Res <i>Subsets: </i>MEDLINE
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              Text: 2014 Jul
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