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A DERL3-associated defect in the degradation of SLC2A1 mediates the Warburg effect.

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Title: A DERL3-associated defect in the degradation of SLC2A1 mediates the Warburg effect.
Authors: Lopez-Serra P; Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet, Barcelona, 08908 Catalonia, Spain., Marcilla M; Proteomics Unit, Spanish National Biotechnology Centre (CNB), CSIC, 28049 Madrid, Spain., Villanueva A; Translational Research Laboratory, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet, Barcelona, 08908 Catalonia, Spain., Ramos-Fernandez A; Proteobotics SL, Spanish National Biotechnology Centre (CNB), Darwin 3, 28049 Madrid, Spain., Palau A; Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet, Barcelona, 08908 Catalonia, Spain., Leal L; Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet, Barcelona, 08908 Catalonia, Spain., Wahi JE; Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet, Barcelona, 08908 Catalonia, Spain., Setien-Baranda F; Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet, Barcelona, 08908 Catalonia, Spain., Szczesna K; Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet, Barcelona, 08908 Catalonia, Spain., Moutinho C; Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet, Barcelona, 08908 Catalonia, Spain., Martinez-Cardus A; Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet, Barcelona, 08908 Catalonia, Spain., Heyn H; Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet, Barcelona, 08908 Catalonia, Spain., Sandoval J; Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet, Barcelona, 08908 Catalonia, Spain., Puertas S; Translational Research Laboratory, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet, Barcelona, 08908 Catalonia, Spain., Vidal A; Bellvitge Biomedical Research Institute (IDIBELL), Department of Pathology, Bellvitge University Hospital, L'Hospitalet, Barcelona, 08908 Catalonia, Spain., Sanjuan X; Bellvitge Biomedical Research Institute (IDIBELL), Department of Pathology, Bellvitge University Hospital, L'Hospitalet, Barcelona, 08908 Catalonia, Spain., Martinez-Balibrea E; Medical Oncology Service, Catalan Institute of Oncology (ICO), l'Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol (IGTP), Hospital Germans Trias I Pujol, Badalona, Barcelona, 08916 Catalonia, Spain., Viñals F; 1] Translational Research Laboratory, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet, Barcelona, 08908 Catalonia, Spain [2] Department of Physiological Sciences II, School of Medicine, University of Barcelona, 08036 Barcelona, Spain., Perales JC; Department of Physiological Sciences II, School of Medicine, University of Barcelona, 08036 Barcelona, Spain., Bramsem JB; Department of Molecular Medicine, Aarhus University Hospital, Brendstrupgaardsvej 100, Aarhus N, DK-8200 Aarhus, Denmark., Ørntoft TF; Department of Molecular Medicine, Aarhus University Hospital, Brendstrupgaardsvej 100, Aarhus N, DK-8200 Aarhus, Denmark., Andersen CL; Department of Molecular Medicine, Aarhus University Hospital, Brendstrupgaardsvej 100, Aarhus N, DK-8200 Aarhus, Denmark., Tabernero J; Medical Oncology Department, Vall d'Hebron University Hospital, Barcelona, 08035 Catalonia, Spain., McDermott U; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK., Boxer MB; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20891-4874, USA., Vander Heiden MG; 1] Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA [2] Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA., Albar JP; Proteomics Unit, Spanish National Biotechnology Centre (CNB), CSIC, 28049 Madrid, Spain., Esteller M; 1] Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet, Barcelona, 08908 Catalonia, Spain [2] Department of Physiological Sciences II, School of Medicine, University of Barcelona, 08036 Barcelona, Spain [3] Institucio Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, 08010 Catalonia, Spain.
Source: Nature communications [Nat Commun] 2014 Apr 03; Vol. 5, pp. 3608. Date of Electronic Publication: 2014 Apr 03.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: A DERL3-associated defect in the degradation of SLC2A1 mediates the Warburg effect.
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  Data: <searchLink fieldCode="AU" term="%22Lopez-Serra+P%22">Lopez-Serra P</searchLink>; Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet, Barcelona, 08908 Catalonia, Spain.<br /><searchLink fieldCode="AU" term="%22Marcilla+M%22">Marcilla M</searchLink>; Proteomics Unit, Spanish National Biotechnology Centre (CNB), CSIC, 28049 Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Villanueva+A%22">Villanueva A</searchLink>; Translational Research Laboratory, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet, Barcelona, 08908 Catalonia, Spain.<br /><searchLink fieldCode="AU" term="%22Ramos-Fernandez+A%22">Ramos-Fernandez A</searchLink>; Proteobotics SL, Spanish National Biotechnology Centre (CNB), Darwin 3, 28049 Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Palau+A%22">Palau A</searchLink>; Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet, Barcelona, 08908 Catalonia, Spain.<br /><searchLink fieldCode="AU" term="%22Leal+L%22">Leal L</searchLink>; Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet, Barcelona, 08908 Catalonia, Spain.<br /><searchLink fieldCode="AU" term="%22Wahi+JE%22">Wahi JE</searchLink>; Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet, Barcelona, 08908 Catalonia, Spain.<br /><searchLink fieldCode="AU" term="%22Setien-Baranda+F%22">Setien-Baranda F</searchLink>; Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet, Barcelona, 08908 Catalonia, Spain.<br /><searchLink fieldCode="AU" term="%22Szczesna+K%22">Szczesna K</searchLink>; Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet, Barcelona, 08908 Catalonia, Spain.<br /><searchLink fieldCode="AU" term="%22Moutinho+C%22">Moutinho C</searchLink>; Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet, Barcelona, 08908 Catalonia, Spain.<br /><searchLink fieldCode="AU" term="%22Martinez-Cardus+A%22">Martinez-Cardus A</searchLink>; 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