Activating mutations in RRAS underlie a phenotype within the RASopathy spectrum and contribute to leukaemogenesis.
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| Title: | Activating mutations in RRAS underlie a phenotype within the RASopathy spectrum and contribute to leukaemogenesis. |
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| Authors: | Flex E; Dipartimento di Ematologia, Oncologia e Medicina Molecolare and., Jaiswal M; Institut für Biochemie und Molekularbiologie II, Medizinische Fakultät der Heinrich-Heine Universitat, Düsseldorf 40225, Germany., Pantaleoni F; Dipartimento di Ematologia, Oncologia e Medicina Molecolare and., Martinelli S; Dipartimento di Ematologia, Oncologia e Medicina Molecolare and., Strullu M; Genetics Department, INSERM UMR_S940, Institut Universitaire D'Hématologie (IUH), Université Paris-Diderot Sorbonne-Paris-Cité, Paris 75010, France., Fansa EK; Institut für Biochemie und Molekularbiologie II, Medizinische Fakultät der Heinrich-Heine Universitat, Düsseldorf 40225, Germany., Caye A; Genetics Department, INSERM UMR_S940, Institut Universitaire D'Hématologie (IUH), Université Paris-Diderot Sorbonne-Paris-Cité, Paris 75010, France., De Luca A; Laboratorio Mendel, Istituto di Ricovero e Cura a Carattere Scientifico-Casa Sollievo Della Sofferenza, Rome 00198, Italy., Lepri F; Ospedale Pediatrico 'Bambino Gesù', Rome 00165, Italy., Dvorsky R; Institut für Biochemie und Molekularbiologie II, Medizinische Fakultät der Heinrich-Heine Universitat, Düsseldorf 40225, Germany., Pannone L; Dipartimento di Ematologia, Oncologia e Medicina Molecolare and., Paolacci S; Dipartimento di Ematologia, Oncologia e Medicina Molecolare and., Zhang SC; Institut für Biochemie und Molekularbiologie II, Medizinische Fakultät der Heinrich-Heine Universitat, Düsseldorf 40225, Germany., Fodale V; Dipartimento di Ematologia, Oncologia e Medicina Molecolare and., Bocchinfuso G; Dipartimento di Scienze e Tecnologie Chimiche, Università 'Tor Vergata', Rome 00133, Italy., Rossi C; UO Genetica Medica, Policlinico S.Orsola-Malpighi, Bologna 40138, Italy., Burkitt-Wright EM; Genetic Medicine, Academic Health Science Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester M13 9WL, UK., Farrotti A; Dipartimento di Scienze e Tecnologie Chimiche, Università 'Tor Vergata', Rome 00133, Italy., Stellacci E; Dipartimento di Ematologia, Oncologia e Medicina Molecolare and., Cecchetti S; Dipartimento di Biologia Cellulare e Neuroscienze, Istituto Superiore di Sanità, Rome 00161, Italy., Ferese R; Laboratorio Mendel, Istituto di Ricovero e Cura a Carattere Scientifico-Casa Sollievo Della Sofferenza, Rome 00198, Italy., Bottero L; Dipartimento di Ematologia, Oncologia e Medicina Molecolare and., Castro S; Istituto di Genetica e Biofisica 'A. Buzzati Traverso', Consiglio Nazionale Delle Ricerche, Naples 80131, Italy., Fenneteau O; Biological Hematology Department and., Brethon B; Pediatric Hematology Department, Robert Debré Hospital, Paris 75019, France., Sanchez M; Dipartimento di Biologia Cellulare e Neuroscienze, Istituto Superiore di Sanità, Rome 00161, Italy., Roberts AE; Department of Cardiology and Division of Genetics, and Department of Medicine, Boston Children's Hospital, Boston, MA 02115, USA., Yntema HG; Department of Human Genetics, Radboud University Medical Centre, and Nijmegen Centre for Molecular Life Sciences, Radboud University, Nijmegen 6500, The Netherlands., Van Der Burgt I; Department of Human Genetics, Radboud University Medical Centre, and Nijmegen Centre for Molecular Life Sciences, Radboud University, Nijmegen 6500, The Netherlands., Cianci P; Genetica Clinica Pediatrica, Clinica Pediatrica Università Milano Bicocca, Fondazione MBBM, A.O. S. Gerardo, Monza 20900, Italy., Bondeson ML; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala 75237, Sweden., Cristina Digilio M; Ospedale Pediatrico 'Bambino Gesù', Rome 00165, Italy., Zampino G; Istituto di Clinica Pediatrica, Università Cattolica del Sacro Cuore, Rome 00168, Italy., Kerr B; Genetic Medicine, Academic Health Science Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester M13 9WL, UK., Aoki Y; Department of Medical Genetics, Tohoku University School of Medicine, Sendai 980-8574, Japan., Loh ML; Department of Pediatrics, Benioff Children's Hospital, University of California School of Medicine, and the Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, 94143, USA., Palleschi A; Dipartimento di Scienze e Tecnologie Chimiche, Università 'Tor Vergata', Rome 00133, Italy., Di Schiavi E; Istituto di Genetica e Biofisica 'A. Buzzati Traverso', Consiglio Nazionale Delle Ricerche, Naples 80131, Italy., Carè A; Dipartimento di Ematologia, Oncologia e Medicina Molecolare and., Selicorni A; Genetica Clinica Pediatrica, Clinica Pediatrica Università Milano Bicocca, Fondazione MBBM, A.O. S. Gerardo, Monza 20900, Italy., Dallapiccola B; Ospedale Pediatrico 'Bambino Gesù', Rome 00165, Italy., Cirstea IC; Institut für Biochemie und Molekularbiologie II, Medizinische Fakultät der Heinrich-Heine Universitat, Düsseldorf 40225, Germany, Leibniz Institute for Age Research, Jena 07745, Germany., Stella L; Dipartimento di Scienze e Tecnologie Chimiche, Università 'Tor Vergata', Rome 00133, Italy., Zenker M; Institute of Human Genetics, University Hospital of Magdeburg, Otto-von-Guericke-University, Magdeburg 39120, Germany., Gelb BD; Department of Pediatrics and Department of Genetics and Department of Genomic Sciences, Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Cavé H; Genetics Department, INSERM UMR_S940, Institut Universitaire D'Hématologie (IUH), Université Paris-Diderot Sorbonne-Paris-Cité, Paris 75010, France., Ahmadian MR; Institut für Biochemie und Molekularbiologie II, Medizinische Fakultät der Heinrich-Heine Universitat, Düsseldorf 40225, Germany., Tartaglia M; Dipartimento di Ematologia, Oncologia e Medicina Molecolare and marco.tartaglia@iss.it. |
| Source: | Human molecular genetics [Hum Mol Genet] 2014 Aug 15; Vol. 23 (16), pp. 4315-27. Date of Electronic Publication: 2014 Apr 04. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: IRL Press at Oxford University Press Country of Publication: England NLM ID: 9208958 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2083 (Electronic) Linking ISSN: 09646906 NLM ISO Abbreviation: Hum Mol Genet Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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