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Potent and Selective Inhibitors of CK2 Kinase Identified through Structure-Guided Hybridization.

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Title: Potent and Selective Inhibitors of CK2 Kinase Identified through Structure-Guided Hybridization.
Authors: Dowling JE; AstraZeneca , Oncology Innovative Medicines Unit, 35 Gatehouse Drive, Waltham, Massachusetts 02145, United States., Chuaqui C; AstraZeneca , Oncology Innovative Medicines Unit, 35 Gatehouse Drive, Waltham, Massachusetts 02145, United States., Pontz TW; AstraZeneca , Oncology Innovative Medicines Unit, 35 Gatehouse Drive, Waltham, Massachusetts 02145, United States., Lyne PD; AstraZeneca , Oncology Innovative Medicines Unit, 35 Gatehouse Drive, Waltham, Massachusetts 02145, United States., Larsen NA; AstraZeneca , Oncology Innovative Medicines Unit, 35 Gatehouse Drive, Waltham, Massachusetts 02145, United States., Block MH; AstraZeneca , Oncology Innovative Medicines Unit, 35 Gatehouse Drive, Waltham, Massachusetts 02145, United States., Chen H; AstraZeneca , Oncology Innovative Medicines Unit, 35 Gatehouse Drive, Waltham, Massachusetts 02145, United States., Su N; AstraZeneca , Oncology Innovative Medicines Unit, 35 Gatehouse Drive, Waltham, Massachusetts 02145, United States., Wu A; AstraZeneca , Oncology Innovative Medicines Unit, 35 Gatehouse Drive, Waltham, Massachusetts 02145, United States., Russell D; AstraZeneca , Oncology Innovative Medicines Unit, 35 Gatehouse Drive, Waltham, Massachusetts 02145, United States., Pollard H; AstraZeneca , Oncology Innovative Medicines Unit, 35 Gatehouse Drive, Waltham, Massachusetts 02145, United States., Lee JW; AstraZeneca , Oncology Innovative Medicines Unit, 35 Gatehouse Drive, Waltham, Massachusetts 02145, United States., Peng B; AstraZeneca , Oncology Innovative Medicines Unit, 35 Gatehouse Drive, Waltham, Massachusetts 02145, United States., Thakur K; AstraZeneca , Oncology Innovative Medicines Unit, 35 Gatehouse Drive, Waltham, Massachusetts 02145, United States., Ye Q; AstraZeneca , Oncology Innovative Medicines Unit, 35 Gatehouse Drive, Waltham, Massachusetts 02145, United States., Zhang T; AstraZeneca , Oncology Innovative Medicines Unit, 35 Gatehouse Drive, Waltham, Massachusetts 02145, United States., Brassil P; AstraZeneca , Oncology Innovative Medicines Unit, 35 Gatehouse Drive, Waltham, Massachusetts 02145, United States., Racicot V; AstraZeneca , Oncology Innovative Medicines Unit, 35 Gatehouse Drive, Waltham, Massachusetts 02145, United States., Bao L; AstraZeneca , Oncology Innovative Medicines Unit, 35 Gatehouse Drive, Waltham, Massachusetts 02145, United States., Denz CR; AstraZeneca , Oncology Innovative Medicines Unit, 35 Gatehouse Drive, Waltham, Massachusetts 02145, United States., Cooke E; AstraZeneca , Oncology Innovative Medicines Unit, 35 Gatehouse Drive, Waltham, Massachusetts 02145, United States.
Source: ACS medicinal chemistry letters [ACS Med Chem Lett] 2012 Jan 24; Vol. 3 (4), pp. 278-83. Date of Electronic Publication: 2012 Jan 24 (Print Publication: 2012).
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Potent and Selective Inhibitors of CK2 Kinase Identified through Structure-Guided Hybridization.
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  Data: <searchLink fieldCode="AU" term="%22Dowling+JE%22">Dowling JE</searchLink>; AstraZeneca , Oncology Innovative Medicines Unit, 35 Gatehouse Drive, Waltham, Massachusetts 02145, United States.<br /><searchLink fieldCode="AU" term="%22Chuaqui+C%22">Chuaqui C</searchLink>; AstraZeneca , Oncology Innovative Medicines Unit, 35 Gatehouse Drive, Waltham, Massachusetts 02145, United States.<br /><searchLink fieldCode="AU" term="%22Pontz+TW%22">Pontz TW</searchLink>; AstraZeneca , Oncology Innovative Medicines Unit, 35 Gatehouse Drive, Waltham, Massachusetts 02145, United States.<br /><searchLink fieldCode="AU" term="%22Lyne+PD%22">Lyne PD</searchLink>; AstraZeneca , Oncology Innovative Medicines Unit, 35 Gatehouse Drive, Waltham, Massachusetts 02145, United States.<br /><searchLink fieldCode="AU" term="%22Larsen+NA%22">Larsen NA</searchLink>; AstraZeneca , Oncology Innovative Medicines Unit, 35 Gatehouse Drive, Waltham, Massachusetts 02145, United States.<br /><searchLink fieldCode="AU" term="%22Block+MH%22">Block MH</searchLink>; AstraZeneca , Oncology Innovative Medicines Unit, 35 Gatehouse Drive, Waltham, Massachusetts 02145, United States.<br /><searchLink fieldCode="AU" term="%22Chen+H%22">Chen H</searchLink>; AstraZeneca , Oncology Innovative Medicines Unit, 35 Gatehouse Drive, Waltham, Massachusetts 02145, United States.<br /><searchLink fieldCode="AU" term="%22Su+N%22">Su N</searchLink>; AstraZeneca , Oncology Innovative Medicines Unit, 35 Gatehouse Drive, Waltham, Massachusetts 02145, United States.<br /><searchLink fieldCode="AU" term="%22Wu+A%22">Wu A</searchLink>; AstraZeneca , Oncology Innovative Medicines Unit, 35 Gatehouse Drive, Waltham, Massachusetts 02145, United States.<br /><searchLink fieldCode="AU" term="%22Russell+D%22">Russell D</searchLink>; AstraZeneca , Oncology Innovative Medicines Unit, 35 Gatehouse Drive, Waltham, Massachusetts 02145, United States.<br /><searchLink fieldCode="AU" term="%22Pollard+H%22">Pollard H</searchLink>; AstraZeneca , Oncology Innovative Medicines Unit, 35 Gatehouse Drive, Waltham, Massachusetts 02145, United States.<br /><searchLink fieldCode="AU" term="%22Lee+JW%22">Lee JW</searchLink>; AstraZeneca , Oncology Innovative Medicines Unit, 35 Gatehouse Drive, Waltham, Massachusetts 02145, United States.<br /><searchLink fieldCode="AU" term="%22Peng+B%22">Peng B</searchLink>; AstraZeneca , Oncology Innovative Medicines Unit, 35 Gatehouse Drive, Waltham, Massachusetts 02145, United States.<br /><searchLink fieldCode="AU" term="%22Thakur+K%22">Thakur K</searchLink>; AstraZeneca , Oncology Innovative Medicines Unit, 35 Gatehouse Drive, Waltham, Massachusetts 02145, United States.<br /><searchLink fieldCode="AU" term="%22Ye+Q%22">Ye Q</searchLink>; AstraZeneca , Oncology Innovative Medicines Unit, 35 Gatehouse Drive, Waltham, Massachusetts 02145, United States.<br /><searchLink fieldCode="AU" term="%22Zhang+T%22">Zhang T</searchLink>; AstraZeneca , Oncology Innovative Medicines Unit, 35 Gatehouse Drive, Waltham, Massachusetts 02145, United States.<br /><searchLink fieldCode="AU" term="%22Brassil+P%22">Brassil P</searchLink>; AstraZeneca , Oncology Innovative Medicines Unit, 35 Gatehouse Drive, Waltham, Massachusetts 02145, United States.<br /><searchLink fieldCode="AU" term="%22Racicot+V%22">Racicot V</searchLink>; AstraZeneca , Oncology Innovative Medicines Unit, 35 Gatehouse Drive, Waltham, Massachusetts 02145, United States.<br /><searchLink fieldCode="AU" term="%22Bao+L%22">Bao L</searchLink>; AstraZeneca , Oncology Innovative Medicines Unit, 35 Gatehouse Drive, Waltham, Massachusetts 02145, United States.<br /><searchLink fieldCode="AU" term="%22Denz+CR%22">Denz CR</searchLink>; AstraZeneca , Oncology Innovative Medicines Unit, 35 Gatehouse Drive, Waltham, Massachusetts 02145, United States.<br /><searchLink fieldCode="AU" term="%22Cooke+E%22">Cooke E</searchLink>; AstraZeneca , Oncology Innovative Medicines Unit, 35 Gatehouse Drive, Waltham, Massachusetts 02145, United States.
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  Data: <searchLink fieldCode="JN" term="%22101521073%22">ACS medicinal chemistry letters</searchLink> [ACS Med Chem Lett] 2012 Jan 24; Vol. 3 (4), pp. 278-83. <i>Date of Electronic Publication: </i>2012 Jan 24 (<i>Print Publication: </i>2012).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101521073 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Print <i>ISSN: </i>1948-5875 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2219485875%22">19485875 </searchLink><i>NLM ISO Abbreviation: </i>ACS Med Chem Lett <i>Subsets: </i>PubMed not MEDLINE
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